N-α-Methyl-L-norvalinamide hydrochloride
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N-α-Methyl-L-norvalinamide hydrochloride

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Category
L-Amino Acids
Catalog number
BAT-002094
CAS number
1315001-07-0
Molecular Formula
C6H15ClN2O
Molecular Weight
166.65
IUPAC Name
2-(methylamino)pentanamide;hydrochloride
Synonyms
H-MeNva-NH2 HCl; N-alpha-Methyl-L-norvalinamide hydrochloride; (2S)-2-(methylamino)pentanamide hydrochloride; H-MeNva-NH2 HCl; H-MeApe(2)-NH2 HCl; (S)-2-(Methylamino)pentanamide hydrochloride
InChI
InChI=1S/C6H14N2O.ClH/c1-3-4-5(8-2)6(7)9;/h5,8H,3-4H2,1-2H3,(H2,7,9);1H
InChI Key
SMVKHTXOXVNEAY-UHFFFAOYSA-N
Canonical SMILES
CCCC(C(=O)N)NC.Cl
1. 1-Haloacylpiperazines
S Groszkowski, J Sienkiewicz, L Korzycka Pol J Pharmacol Pharm. 1975 Apr-Jun;27(2):183-6.
By direct acylation of piperazine with halogenocarboxylic acid chlorides in acid medium, the hydrochlorides of 1-haloacylpiperazines were obtained.
2. Metal-free and regiospecific synthesis of 3-arylindoles
Chuangchuang Xu, Wenlai Xie, Jiaxi Xu Org Biomol Chem. 2020 Apr 8;18(14):2661-2671. doi: 10.1039/d0ob00317d.
A convenient, metal-free, and organic acid-base promoted synthetic method to prepare 3-arylindoles from 3-aryloxirane-2-carbonitriles and arylhydrazine hydrochlorides has been developed. In the reaction, the organic acid catalyzes a tandem nucleophilic ring-opening reaction of aryloxiranecarbonitriles and arylhydrazine hydrochlorides and Fischer indolization. The organic base triethylamine plays a crucial role in the final elimination step in the Fischer indole synthesis, affording 3-arylindoles regiospecifically. The reaction features advantages of microwave acceleration, non-metal participation, short reaction time, organic acid-base co-catalysis, and broad substrate scope.
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