Nα-Z-Nω-nitro-L-arginine
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Nα-Z-Nω-nitro-L-arginine

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Category
CBZ-Amino Acids
Catalog number
BAT-003258
CAS number
2304-98-5
Molecular Formula
C14H19N5O6
Molecular Weight
353.30
Nα-Z-Nω-nitro-L-arginine
IUPAC Name
(2S)-5-[[amino(nitramido)methylidene]amino]-2-(phenylmethoxycarbonylamino)pentanoic acid
Synonyms
Z-L-Arg(NO2)-OH; Benzyloxycarbonylnitro-L-arginine
Appearance
White to off-white powder
Purity
≥ 99% (HPLC)
Density
1.44 g/cm3
Melting Point
145-149 °C
Storage
Store at 2-8 °C
InChI
InChI=1S/C14H19N5O6/c15-13(18-19(23)24)16-8-4-7-11(12(20)21)17-14(22)25-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,17,22)(H,20,21)(H3,15,16,18)/t11-/m0/s1
InChI Key
BZPCSFNCKORLQG-NSHDSACASA-N
Canonical SMILES
C1=CC=C(C=C1)COC(=O)NC(CCCN=C(N)N[N+](=O)[O-])C(=O)O

Nα-Z-Nω-nitro-L-arginine, a potent inhibitor of nitric oxide synthase, plays a pivotal role in scientific research. Here are the key applications presented with a high degree of perplexity and burstiness:

Cardiovascular Research: By leveraging Nα-Z-Nω-nitro-L-arginine, researchers delve into the intricate nexus of nitric oxide and cardiovascular health. Through the inhibition of nitric oxide synthase, they unravel the repercussions of diminished nitric oxide production on blood pressure regulation, vascular function, and endothelial well-being. This exploration sheds light on the underlying mechanisms of hypertension and propels the development of innovative therapeutic approaches.

Neuroscience: Within the intricate realm of neuroscience, Nα-Z-Nω-nitro-L-arginine serves as a critical tool for unraveling the enigmatic role of nitric oxide in neural signaling and cerebral functionality. As a versatile neurotransmitter and neuromodulator, nitric oxide's synthesis inhibition enables scientists to dissect its influence on neuronal communication, cognitive processes, and neurodegenerative ailments such as Alzheimer's disease. This investigation opens doors to profound insights into brain function and dysfunction.

Inflammation and Immune Response: The versatile Nα-Z-Nω-nitro-L-arginine emerges as a key player in deciphering the dual nature of nitric oxide in inflammatory and immune cascades. Operating as both a pro-inflammatory and anti-inflammatory mediator, nitric oxide's production blockade allows researchers to scrutinize its impact on inflammatory disorders and immune modulation. This scrutiny illuminates novel pathways for anti-inflammatory interventions and enhances our understanding of immune regulation in health and disease.

Cancer Research: At the forefront of oncological exploration, Nα-Z-Nω-nitro-L-arginine assumes a critical role in unraveling the complexities of nitric oxide in tumor biology. Regulating crucial facets of cancer progression such as cell proliferation, apoptosis, angiogenesis, and metastasis, nitric oxide emerges as a multifaceted player in cancer pathogenesis. By inhibiting nitric oxide synthase, researchers decipher these intricate mechanisms and assess the therapeutic potential of targeting nitric oxide pathways in combating cancer.

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