Nα-Z-Nγ-trityl-D-asparagine
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Nα-Z-Nγ-trityl-D-asparagine

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Category
CBZ-Amino Acids
Catalog number
BAT-003241
CAS number
200259-87-6
Molecular Formula
C31H28N2O5
Molecular Weight
508.60
Nα-Z-Nγ-trityl-D-asparagine
IUPAC Name
(2R)-4-oxo-2-(phenylmethoxycarbonylamino)-4-(tritylamino)butanoic acid
Synonyms
Z-D-Asn(Trt)-OH
Appearance
White to off-white powder
Purity
≥ 98% (HPLC)
Density
1.253±0.06 g/cm3(Predicted)
Melting Point
184-191 °C
Boiling Point
776.0±60.0 °C(Predicted)
Storage
Store at 2-8 °C
InChI
InChI=1S/C31H28N2O5/c34-28(21-27(29(35)36)32-30(37)38-22-23-13-5-1-6-14-23)33-31(24-15-7-2-8-16-24,25-17-9-3-10-18-25)26-19-11-4-12-20-26/h1-20,27H,21-22H2,(H,32,37)(H,33,34)(H,35,36)/t27-/m1/s1
InChI Key
FPVBKISSJULIGI-HHHXNRCGSA-N
Canonical SMILES
C1=CC=C(C=C1)COC(=O)NC(CC(=O)NC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)O

Nα-Z-Nγ-trityl-D-asparagine, a protected amino acid derivative, finds diverse applications in various biochemical contexts. Here are the key applications of Nα-Z-Nγ-trityl-D-asparagine, presented with high perplexity and burstiness:

Peptide Synthesis: Widely utilized in the synthesis of peptides and small proteins, Nα-Z-Nγ-trityl-D-asparagine plays a pivotal role. Its trityl group provides protection during peptide bond formation, ensuring the asparagine side chain remains inert until the desired peptide length is achieved. This selective safeguard is indispensable for crafting intricate peptides with exceptional precision.

Drug Development: In the realm of pharmaceutical research, Nα-Z-Nγ-trityl-D-asparagine shines as a vital component in creating peptide-based drug candidates. By integrating this modified amino acid into peptide sequences, researchers can fashion and evaluate novel therapeutic agents with heightened stability and bioavailability. This strategy aids in concocting targeted treatments for a spectrum of diseases, including cancer and metabolic disorders, heralding a new era in medicinal advancement.

Protein Engineering: Central to structural biology and protein engineering, Nα-Z-Nγ-trityl-D-asparagine assumes a crucial role. Researchers harness its potential to introduce specific alterations in protein sequences, facilitating the exploration of protein folding, stability, and function. These modifications offer insights into the structural prerequisites for protein activity and aid in designing proteins endowed with enhanced attributes.

Immunological Research: Within the realm of immunology, Nα-Z-Nγ-trityl-D-asparagine becomes an indispensable tool in the production of synthetic antigens and vaccines. By integrating it into antigenic peptides, scientists can manufacture highly specific probes for probing immune responses. This methodology proves particularly valuable in crafting peptide vaccines and diagnostic tools for combating infectious diseases and autoimmune maladies, marking a significant stride in immunological research.

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