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Nemifitide acetate

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Nemifitide acetate is an antidepressant with a pentapeptide structure similar to melanocyte-inhibiting factor (MIF). It binds to several receptors, including 5-HT2A (as an antagonist), NPY1, bombesin, MC4, and MC5, although only in micromolar concentrations.

Category

Peptide Inhibitors

Catalog number

BAT-016300

Molecular Formula

C35H47FN10O8

Molecular Weight

754.85

Specification

IUPAC Name

acetic acid;(2S,4R)-1-[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]-N-[(2S)-1-[[2-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-hydroxypyrrolidine-2-carboxamide

Synonyms

INN 00835 acetate; H-Phe(4-F)-Hyp-Arg-Gly-Trp-NH2.CH3CO2H; 4-fluoro-L-phenylalanyl-(4R)-4-hydroxy-L-prolyl-L-arginyl-glycyl-L-tryptophanamide acetic acid; 4-F-Phe-4-OH-Pro-Arg-Gly-Trp-NH2.CH3CO2H

Related CAS

173240-15-8 (free base)

Purity

≥95%

Sequence

Phe(4-F)-Hyp-Arg-Gly-Trp-NH2.CH3CO2H

Storage

Store at -20°C

Solubility

Soluble in DMSO

InChI

InChI=1S/C33H43FN10O6.C2H4O2/c34-20-9-7-18(8-10-20)12-23(35)32(50)44-17-21(45)14-27(44)31(49)43-25(6-3-11-39-33(37)38)30(48)41-16-28(46)42-26(29(36)47)13-19-15-40-24-5-2-1-4-22(19)24;1-2(3)4/h1-2,4-5,7-10,15,21,23,25-27,40,45H,3,6,11-14,16-17,35H2,(H2,36,47)(H,41,48)(H,42,46)(H,43,49)(H4,37,38,39);1H3,(H,3,4)/t21-,23+,25+,26+,27+;/m1./s1

InChI Key

KODFJVOHBXAGDY-XYYXENNDSA-N

Canonical SMILES

CC(=O)O.C1C(CN(C1C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)N)C(=O)C(CC4=CC=C(C=C4)F)N)O