PAMP-12 (human, porcine) acetate
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PAMP-12 (human, porcine) acetate

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PAMP-12(human, porcine) acetate, a major component of ir-PAMP, is an endogenous peptide agonist of Mas-related GPR X2 (MRGPRX2).

Category
Peptide Inhibitors
Catalog number
BAT-016335
Molecular Formula
C79H123N25O16
Molecular Weight
1678.98
PAMP-12 (human, porcine) acetate
IUPAC Name
acetic acid;(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]butanediamide
Synonyms
H-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2.CH3CO2H; L-phenylalanyl-L-arginyl-L-lysyl-L-lysyl-L-tryptophyl-L-asparagyl-L-lysyl-L-tryptophyl-L-alanyl-L-leucyl-L-seryl-L-argininamide acetic acid; 9-20-Proadrenomedullin (pig) acetate; Human PAMP(9-20) acetate; Human PAMP-12 acetate; PAMP 9-20 acetate; Porcine PAMP 12 acetate; Porcine PAMP(9-20) acetate
Related CAS
196305-05-2 (free base)
Purity
≥95%
Sequence
FRKKWNKWALSR-NH2.CH3CO2H
Storage
Store at -20°C
InChI
InChI=1S/C77H119N25O14.C2H4O2/c1-43(2)35-58(72(113)102-62(42-103)75(116)93-53(64(83)105)28-17-33-88-76(84)85)98-65(106)44(3)92-71(112)59(37-46-40-90-51-23-9-7-21-48(46)51)99-70(111)56(27-13-16-32-80)97-74(115)61(39-63(82)104)101-73(114)60(38-47-41-91-52-24-10-8-22-49(47)52)100-69(110)55(26-12-15-31-79)96-67(108)54(25-11-14-30-78)95-68(109)57(29-18-34-89-77(86)87)94-66(107)50(81)36-45-19-5-4-6-20-45;1-2(3)4/h4-10,19-24,40-41,43-44,50,53-62,90-91,103H,11-18,25-39,42,78-81H2,1-3H3,(H2,82,104)(H2,83,105)(H,92,112)(H,93,116)(H,94,107)(H,95,109)(H,96,108)(H,97,115)(H,98,106)(H,99,111)(H,100,110)(H,101,114)(H,102,113)(H4,84,85,88)(H4,86,87,89);1H3,(H,3,4)/t44-,50-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-;/m0./s1
InChI Key
YQKOMUCYGATCOU-DRWCHAHRSA-N
Canonical SMILES
CC(C)CC(C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)N)NC(=O)C(C)NC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC5=CC=CC=C5)N.CC(=O)O
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