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Phe(5-Br-2-CF2H) is a modified phenylalanine derivative where the phenyl ring is substituted with a bromine (Br) atom at the 5-position and a difluoromethyl group (CF2H) at the 2-position. This combination of halogenation and the trifluoromethyl group introduces strong electron-withdrawing effects and enhances the hydrophobicity of the phenylalanine residue. Such modifications are used in peptide synthesis to influence the structure, stability, and biological interactions of peptides, potentially improving their performance in therapeutic or research settings. The specific substitution pattern is particularly useful for altering binding affinity, resistance to degradation, or other key properties in peptide-based compounds.
