Pidotimod Impurity (BAT-008084)
* For research use only

Timonacic is a cyclic sulfur amino acid derivative with potential antineoplastic and antioxidant activities. Acting on cellular membranes of malignant cells through an unknown mechanism, timonacic may induce malignant cells to revert back to an untransformed state. This agent may also restore contact inhibition, a phenomenon characterized by the paracrine inhibition of mitosis following the formation of a critical cell mass, presumably the result of cell-to-cell signal transfer. Timonacic may also produce antioxidant effects secondary to its release of cysteine and restoration of glutathione concentrations.

Category
Cyclic Amino Acids
Catalog number
BAT-008084
CAS number
34592-47-7
Molecular Formula
C4H7NO2S
Molecular Weight
133.17
Pidotimod Impurity
IUPAC Name
(4R)-1,3-thiazolidine-4-carboxylic acid
Synonyms
Timonacic; L-Thiazolidine-4-carboxylic acid; T4C.
Appearance
White powder
Purity
≥ 98.5% (assay)
Density
1.38 g/cm3
Melting Point
>195°C (dec.)
Boiling Point
350.3ºC at 760 mmHg
Storage
Store at RT
Solubility
Soluble in DMSO, Water
InChI
InChI=1S/C4H7NO2S/c6-4(7)3-1-8-2-5-3/h3,5H,1-2H2,(H,6,7)/t3-/m0/s1
InChI Key
DZLNHFMRPBPULJ-VKHMYHEASA-N
Canonical SMILES
C1C(NCS1)C(=O)O
1.Spectrophotometric investigation of the formed chelate between timonacic and palladium(II) and its analytical applications.
Bakry RS1, Razak OA, el Walily AF, Belal SF. J Pharm Biomed Anal. 1998 May;17(1):95-101.
A simple spectrophotometric method for the determination of timonacic is presented. The procedure is based on the chelate formation with palladium(II) chloride in buffered medium. The optimum conditions for the complex formation were ascertained and the method was developed for the determination of timonacic in the concentration range of 28-48 micrograms ml-1. The emperical formula of the formed complex was determined, by applying different spectrophotometric methods, at optimum pH of 4.8 and an ionic strength of mu = 0.5. The stoichiometric ratio was found to be 2:1 (timonacic/palladium) as calculated by the mole ratio, continuous variations and Asmus methods. The continuous variations and Nash methods were applied for the determination of the conditional stability constant of the formed yellow-water soluble complex and was found to be 3.27 x 10(7). The proposed methods was found to be suitable for the determination of timonacic in bulk and in its pharmaceutical tablets.
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It is commonly abbreviated as: C1V1 = C2V2

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