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Copper tripeptide 1

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Copper tripeptide 1 is a naturally occurring tripeptide that was isolated from human albumin by LorenPickart in 1973. Copper tripeptide 1 can increase the production of collagen, elastin, proteoglycan, and glycosaminoglycan mRNA in fibroblasts. It is a natural regulator of multiple cellular pathways in skin regeneration. GHK-Cu stimulates the production of collagen and is used in anti-aging products. GHK-Cu also exhibits a therapeutic effect on hair loss.

Category

Cosmetic Peptides

Catalog number

BAT-010753

CAS number

89030-95-5

Molecular Formula

C14H22CuN6O4

Molecular Weight

401.91

Size	Price	Stock	Quantity
5 g	$386	In stock

Specification
Reference Reading

IUPAC Name

copper;(2S)-6-amino-2-[[(2S)-2-(2-aminoacetyl)azanidyl-3-(1H-imidazol-4-yl)propanoyl]amino]hexanoate

Synonyms

GHK-Cu; Prezatide Copper; L-Lysine, N2-(N-glycyl-L-histidyl)-, copper complex; [Glycyl-κN-L-histidyl-κN,κN3-L-lysinato(2-)]copper; Copper, [N2-(N-glycyl-L-histidyl)-L-lysinato(2-)]-; Copper peptide GHK-Cu; Copper tripeptide 1; Copper tripeptide-1; Cu-Tripeptide-1; GHK Copper; GHK-Cu Tripeptide; Copper peptide; H-Gly-His-Lys-OH Copper; H-GHK-OH Copper

Related CAS

49557-75-7 (free acid) 77263-24-2 (Deleted CAS) 89411-93-8 (Deleted CAS) 1813541-87-5 (Deleted CAS) 2126821-65-4 (Deleted CAS)

Purity

>95%

Sequence

Gly-His-Lys.Cu

Storage

Store at 2-8°C, under inert gas (nitrogen or Argon)

Solubility

Soluble in DMSO

InChI

InChI=1S/C14H24N6O4.Cu/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9;/h7-8,10-11H,1-6,15-16H2,(H4,17,18,19,20,21,22,23,24);/q;+2/p-2/t10-,11-;/m0./s1

InChI Key

QMIFIFIYYPUVNU-ACMTZBLWSA-L

Canonical SMILES

C1=C(N=CN1)CC(C(=O)NC(CCCCN)C(=O)[O-])[N-]C(=O)CN.[Cu+2]

2. Copper-induced cell death

Martha A Kahlson, Scott J Dixon Science. 2022 Mar 18;375(6586):1231-1232. doi: 10.1126/science.abo3959. Epub 2022 Mar 17.

Excess copper causes mitochondrial protein aggregation and triggers a distinct form of cell death.

3. Copper: effects of deficiency and overload

Ivo Scheiber, Ralf Dringen, Julian F B Mercer Met Ions Life Sci. 2013;13:359-87. doi: 10.1007/978-94-007-7500-8_11.

Copper is an essential trace metal that is required for the catalysis of several important cellular enzymes. However, since an excess of copper can also harm cells due to its potential to catalyze the generation of toxic reactive oxygen species, transport of copper and the cellular copper content are tightly regulated. This chapter summarizes the current knowledge on the importance of copper for cellular processes and on the mechanisms involved in cellular copper uptake, storage and export. In addition, we will give an overview on disturbances of copper homeostasis that are characterized by copper overload or copper deficiency or have been connected with neurodegenerative disorders.