Pro-Hyp-OH
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Pro-Hyp-OH

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Pro-Hyp-OH, a collagen peptide composed of proline (Pro) and hydroxyproline (Hyp), has been studied for its potential role in weight loss and anti-aging effects. Research indicates that this peptide can promote the extracellular matrix gene expression in cultured human fibroblasts, which may contribute to its anti-aging properties. Additionally, H-Pro-Hyp-OH has been reported to be an orally active bioactive peptide against UVB-induced skin aging, highlighting its use in cosmetic applications. Furthermore, studies have shown that ingestion of gelatin, which contains peptides like Pro-Hyp, can increase levels of Pro-Hyp in human plasma, suggesting a potential role in improving physical conditions and possibly aiding in weight management. The absorption of these collagen-derived peptides in human plasma implies that they could have systemic effects, including those related to skin health and potentially, body composition. Therefore, H-Pro-Hyp-OH is not only significant in the realm of anti-aging and skin health but also holds promise as a component in weight loss products due to its impact on collagen metabolism and plasma peptide levels.

Category
Cosmetic Peptides
Catalog number
BAT-006537
CAS number
18684-24-7
Molecular Formula
C10H16N2O4
Molecular Weight
228.25
Pro-Hyp-OH
IUPAC Name
(2S,4R)-4-hydroxy-1-[(2S)-pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
Synonyms
Prolylhydroxyproline; H-Pro-Hyp-OH; Pro-Hyp; Dipeptide-6; L-Prolyl-(4R)-4-hydroxy-L-proline; L-Prolyl-L-hydroxyproline; (2S,4R)-4-Hydroxy-1-((S)-pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid; (2S,4R)-1-(L-Prolyl)-4-hydroxypyrrolidine-2-carboxylic acid; 4-Hydroxy-1-L-prolyl-proline; 4-Hydroxy-1-L-prolyl-L-proline; L-Pro-L-Hyp; L-4-Hydroxy-1-L-prolyl-proline; (4R)-L-Prolyl-4-hydroxy-L-proline
Appearance
White to off-white powder
Purity
≥98% by HPLC
Density
1.417±0.06 g/cm3
Melting Point
152-154 °C
Boiling Point
513.5±50.0 °C at 760 mmHg
Sequence
Pro-Hyp
Storage
Store at -20 °C
Solubility
Soluble in Acid Solution (Slightly), DMSO (Slightly), Methanol (Slightly)
InChI
InChI=1S/C10H16N2O4/c13-6-4-8(10(15)16)12(5-6)9(14)7-2-1-3-11-7/h6-8,11,13H,1-5H2,(H,15,16)/t6-,7+,8+/m1/s1
InChI Key
ONPXCLZMBSJLSP-CSMHCCOUSA-N
Canonical SMILES
C1CC(NC1)C(=O)N2CC(CC2C(=O)O)O
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