pTH-Related Protein (1-40) (human, mouse, rat)
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pTH-Related Protein (1-40) (human, mouse, rat)

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pTH-Related Protein (1-40) (human, mouse, rat) significantly increases the secretion of low Ca2+-stimulated pTH in normal rats in a dose-dependent manner. It stimulates the activity of membrane associated protein kinase C in rat spleen lymphocytes.

Category
Functional Peptides
Catalog number
BAT-015190
CAS number
120298-73-9
Molecular Formula
C207H334N66O58
Molecular Weight
4675.27
pTH-Related Protein (1-40) (human, mouse, rat)
IUPAC Name
(4S)-4-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-carboxypropanoyl]amino]hexanoyl]amino]acetyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]-5-oxopentanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]-5-[[(2S,3S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-5-carbamimidamido-1-[[(2S)-1-[[(2S,3R)-1-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid
Synonyms
Hypercalcemia of Malignancy Factor (1-40) (human, mouse, rat); H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Ile-Arg-Ala-Thr-Ser-OH; pTHrP (1-40) (human, mouse, rat); L-alanyl-L-valyl-L-seryl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-leucyl-L-leucyl-L-histidyl-L-alpha-aspartyl-L-lysyl-glycyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-alpha-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-histidyl-L-histidyl-L-leucyl-L-isoleucyl-L-alanyl-L-alpha-glutamyl-L-isoleucyl-L-histidyl-L-threonyl-L-alanyl-L-alpha-glutamyl-L-isoleucyl-L-arginyl-L-alanyl-L-threonyl-L-serine; PTH-Like Adenylate Cyclase Stimulating Protein
Appearance
White or Off-white Lyophilized Powder
Purity
95%
Sequence
AVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATS
Storage
Store at -20°C
InChI
InChI=1S/C207H334N66O58/c1-27-105(17)159(197(324)237-110(22)166(293)240-132(59-64-155(286)287)179(306)269-162(108(20)30-4)200(327)263-144(82-121-89-225-98-235-121)193(320)273-163(113(25)277)201(328)238-111(23)167(294)241-131(58-63-154(284)285)178(305)268-160(106(18)28-2)198(325)248-124(51-41-67-226-204(213)214)170(297)236-112(24)168(295)272-164(114(26)278)202(329)266-149(93-276)203(330)331)270-192(319)137(75-103(13)14)254-187(314)141(79-118-86-222-95-232-118)260-188(315)142(80-119-87-223-96-233-119)258-183(310)136(74-102(11)12)252-184(311)139(77-116-47-35-32-36-48-116)256-185(312)138(76-115-45-33-31-34-46-115)255-174(301)127(54-44-70-229-207(219)220)244-172(299)125(52-42-68-227-205(215)216)243-173(300)126(53-43-69-228-206(217)218)245-180(307)133(71-99(5)6)253-191(318)146(84-157(290)291)261-176(303)129(56-61-151(212)280)249-199(326)161(107(19)29-3)271-195(322)148(92-275)264-171(298)123(50-38-40-66-209)239-152(281)90-230-169(296)122(49-37-39-65-208)242-190(317)145(83-156(288)289)262-189(316)143(81-120-88-224-97-234-120)259-182(309)135(73-101(9)10)251-181(308)134(72-100(7)8)250-175(302)128(55-60-150(211)279)246-186(313)140(78-117-85-221-94-231-117)257-177(304)130(57-62-153(282)283)247-194(321)147(91-274)265-196(323)158(104(15)16)267-165(292)109(21)210/h31-36,45-48,85-89,94-114,122-149,158-164,274-278H,27-30,37-44,49-84,90-93,208-210H2,1-26H3,(H2,211,279)(H2,212,280)(H,221,231)(H,222,232)(H,223,233)(H,224,234)(H,225,235)(H,230,296)(H,236,297)(H,237,324)(H,238,328)(H,239,281)(H,240,293)(H,241,294)(H,242,317)(H,243,300)(H,244,299)(H,245,307)(H,246,313)(H,247,321)(H,248,325)(H,249,326)(H,250,302)(H,251,308)(H,252,311)(H,253,318)(H,254,314)(H,255,301)(H,256,312)(H,257,304)(H,258,310)(H,259,309)(H,260,315)(H,261,303)(H,262,316)(H,263,327)(H,264,298)(H,265,323)(H,266,329)(H,267,292)(H,268,305)(H,269,306)(H,270,319)(H,271,322)(H,272,295)(H,273,320)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,290,291)(H,330,331)(H4,213,214,226)(H4,215,216,227)(H4,217,218,228)(H4,219,220,229)/t105-,106-,107-,108-,109-,110-,111-,112-,113+,114+,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,158-,159-,160-,161-,162-,163-,164-/m0/s1
InChI Key
GYPQHFRYIQYNHT-YDCCLFLGSA-N
Canonical SMILES
CCC(C)C(C(=O)NC(CCCNC(=N)N)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(CC1=CNC=N1)NC(=O)C(C(C)CC)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(C(C)CC)NC(=O)C(CC(C)C)NC(=O)C(CC2=CNC=N2)NC(=O)C(CC3=CNC=N3)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(CC6=CNC=N6)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)N)NC(=O)C(CC7=CNC=N7)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)C(C)N
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