(Pyr3)-Amyloid β-Protein (3-40)

(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-carbamimidamido-2-[[(2S)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]pentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-carboxybutanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-5-oxopentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[[2-[[(2S)-1-[[(2S,3S)-1-[[(2S,3S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[2-[[(2S)-1-[[(1S)-1-carboxy-2-methylpropyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

Pyr-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH; L-pyroglutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-seryl-glycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionyl-L-valyl-glycyl-glycyl-L-valyl-L-valine

White Powder

≥95%

pEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV

Store at -20°C

Soluble in DMSO

InChI=1S/C187H283N51O53S/c1-24-100(19)153(181(285)203-85-140(248)210-120(66-92(3)4)167(271)219-119(61-65-292-23)165(269)232-147(94(7)8)179(283)201-81-137(245)198-82-142(250)231-149(96(11)12)184(288)236-152(99(17)18)186(290)291)238-185(289)154(101(20)25-2)237-156(260)102(21)207-138(246)83-199-157(261)112(46-35-37-62-188)214-174(278)129(75-135(191)243)225-178(282)133(88-240)212-141(249)86-202-180(284)148(95(9)10)233-177(281)131(77-146(257)258)226-163(267)117(55-59-143(251)252)213-155(259)103(22)208-166(270)123(68-104-40-29-26-30-41-104)222-170(274)125(70-106-44-33-28-34-45-106)228-182(286)151(98(15)16)235-176(280)121(67-93(5)6)220-159(263)113(47-36-38-63-189)215-162(266)116(53-57-134(190)242)217-171(275)126(72-108-78-194-89-204-108)224-173(277)128(74-110-80-196-91-206-110)229-183(287)150(97(13)14)234-164(268)118(56-60-144(253)254)218-168(272)122(71-107-49-51-111(241)52-50-107)211-139(247)84-200-158(262)132(87-239)230-175(279)130(76-145(255)256)227-172(276)127(73-109-79-195-90-205-109)223-160(264)114(48-39-64-197-187(192)193)216-169(273)124(69-105-42-31-27-32-43-105)221-161(265)115-54-58-136(244)209-115/h26-34,40-45,49-52,78-80,89-103,112-133,147-154,239-241H,24-25,35-39,46-48,53-77,81-88,188-189H2,1-23H3,(H2,190,242)(H2,191,243)(H,194,204)(H,195,205)(H,196,206)(H,198,245)(H,199,261)(H,200,262)(H,201,283)(H,202,284)(H,203,285)(H,207,246)(H,208,270)(H,209,244)(H,210,248)(H,211,247)(H,212,249)(H,213,259)(H,214,278)(H,215,266)(H,216,273)(H,217,275)(H,218,272)(H,219,271)(H,220,263)(H,221,265)(H,222,274)(H,223,264)(H,224,277)(H,225,282)(H,226,267)(H,227,276)(H,228,286)(H,229,287)(H,230,279)(H,231,250)(H,232,269)(H,233,281)(H,234,268)(H,235,280)(H,236,288)(H,237,260)(H,238,289)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,290,291)(H4,192,193,197)/t100-,101-,102-,103-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,147-,148-,149-,150-,151-,152-,153-,154-/m0/s1

FYEDIRCAAAEJOI-CBHOIQBCSA-N

CCC(C)C(C(=O)NC(C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(=O)NC(C(C)C)C(=O)NCC(=O)NCC(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)O)NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C(CO)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)N)NC(=O)C(CC3=CNC=N3)NC(=O)C(CC4=CNC=N4)NC(=O)C(C(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)CNC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(CC6=CNC=N6)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C8CCC(=O)N8