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Application Area

(R)-3-t-Butyl-β-alanine

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Category

D-Amino Acids

Catalog number

BAT-008780

CAS number

367278-49-7

Molecular Formula

C7H15NO2

Molecular Weight

145.2

IUPAC Name

(3R)-3-amino-4,4-dimethylpentanoic acid

Synonyms

(R)-3-amino-4,4-dimethylpentanoic acid

Purity

95%

Density

1.016 g/cm3

Boiling Point

241.6°C at 760 mmHg

InChI

InChI=1S/C7H15NO2/c1-7(2,3)5(4-8)6(9)10/h5H,4,8H2,1-3H3,(H,9,10)/t5-/m1/s1

InChI Key

MVGZPYGHSNPXQQ-RXMQYKEDSA-N

Canonical SMILES

CC(C)(C)C(CN)C(=O)O

(R)-3-t-Butyl-β-alanine, an amino acid derivative with diverse applications in the bioscience industry, plays a pivotal role in various realms. Here are the key applications presented with high perplexity and burstiness:

Pharmaceutical Development: Acting as a cornerstone in the synthesis of pharmaceutical compounds, (R)-3-t-Butyl-β-alanine acts as a crucial precursor, enabling the creation of drugs with superior pharmacological characteristics such as enhanced stability and bioavailability. Researchers harness the unique structure of this compound to craft innovative therapeutic agents tailored for diverse medical conditions, pushing the boundaries of drug development towards unparalleled efficacy.

Biochemical Research: Within the realm of biochemical studies, (R)-3-t-Butyl-β-alanine emerges as a versatile tool for probing enzyme interactions and metabolic pathways. Serving as both a substrate and an inhibitor in enzymatic assays, it aids scientists in unraveling the intricate mechanisms and regulatory functions of enzymes, paving the way for a deeper understanding of fundamental biological processes and the potential development of enzyme-targeted therapeutic interventions.

Nutritional Supplements: Delving into the domain of nutritional supplements, (R)-3-t-Butyl-β-alanine finds its niche in formulations aimed at enhancing athletic performance and muscle endurance. As a derivative of beta-alanine, it exhibits the potential to elevate muscle carnosine levels, buffering acid in muscles and mitigating fatigue. This application holds particular significance for athletes and fitness enthusiasts striving to optimize their exercise outcomes, offering a pathway to heightened physical performance.

Chemical Synthesis: In the intricate landscape of organic chemistry, (R)-3-t-Butyl-β-alanine emerges as a valuable chiral building block pivotal for the asymmetric synthesis of complex molecules. Leveraging its unique stereochemistry, scientists utilize it in the creation of enantiomerically pure compounds essential for the development of specific pharmaceuticals and fine chemicals that demand precision and purity. This utilization underscores the indispensable role of (R)-3-t-Butyl-β-alanine in pushing the frontiers of chemical synthesis towards exacting standards and novel discoveries.

1. Management of thyroid cancer: United Kingdom National Multidisciplinary Guidelines

A L Mitchell, A Gandhi, D Scott-Coombes, P Perros Practice J Laryngol Otol. 2016 May;130(S2):S150-S160. doi: 10.1017/S0022215116000578.

This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. This paper provides recommendations on the management of thyroid cancer in adults and is based on the 2014 British Thyroid Association guidelines. Recommendations · Ultrasound scanning (USS) of the nodule or goitre is a crucial investigation in guiding the need for fine needle aspiration cytology (FNAC).

2. Relationship between core stability, functional movement, and performance

Tomoko Okada, Kellie C Huxel, Thomas W Nesser J Strength Cond Res. 2011 Jan;25(1):252-61. doi: 10.1519/JSC.0b013e3181b22b3e.

The purpose of this study was to determine the relationship between core stability, functional movement, and performance. Twenty-eight healthy individuals (age = 24.4 ± 3.9 yr, height = 168.8 ± 12.5 cm, mass = 70.2 ± 14.9 kg) performed several tests in 3 categories: core stability (flexion [FLEX], extension [EXT], right and left lateral [LATr/LATl]), functional movement screen (FMS) (deep squat [DS], trunk-stability push-up [PU], right and left hurdle step [HSr/HSl], in-line lunge [ILLr/ILLl], shoulder mobility [SMr/SMl], active straight leg raise [ASLRr/ASLRl], and rotary stability [RSr/RSl]), and performance tests (backward medicine ball throw [BOMB], T-run [TR], and single leg squat [SLS]). Statistical significance was set at p ≤ 0.05. There were significant correlations between SLS and FLEX (r = 0.500), LATr (r = 0.495), and LATl (r = 0.498). The TR correlated significantly with both LATr (r = 0.383) and LATl (r = 0.448). Of the FMS, BOMB was significantly correlated with HSr (r = 0.415), SMr (r = 0.388), PU (r = 0.407), and RSr (r = 0.391). The TR was significantly related with HSr (r = 0.518), ILLl (r = 0.462) and SMr (r = 0.392). The SLS only correlated significantly with SMr (r = 0.446). There were no significant correlations between core stability and FMS. Moderate to weak correlations identified suggest core stability and FMS are not strong predictors of performance. In addition, existent assessments do not satisfactorily confirm the importance of core stability on functional movement. Despite the emphasis fitness professionals have placed on functional movement and core training for increased performance, our results suggest otherwise. Although training for core and functional movement are important to include in a fitness program, especially for injury prevention, they should not be the primary emphasis of any training program.

3. Linking big five personality traits to sexuality and sexual health: A meta-analytic review

Mark S Allen, Emma E Walter Psychol Bull. 2018 Oct;144(10):1081-1110. doi: 10.1037/bul0000157. Epub 2018 Jun 7.

This meta-analytic review addresses whether the major dimensions of trait personality relate to components of human sexuality. A comprehensive literature search identified 137 studies that met inclusion criteria (761 effect sizes; total n = 420,595). Pooled mean effects were computed using inverse-variance weighted random effects meta-analysis. Mean effect sizes from 100 separate meta-analyses provided evidence that personality relates to theoretically predicted components of sexuality and sexual health. Neuroticism was positively related to sexual dissatisfaction (r+ = .18), negative emotions (r+ = .42), and symptoms of sexual dysfunction (r+ = .16). Extraversion was positively related to sexual activity (r+ = .17) and risky sexual behavior (r+ = .18), and negatively related to symptoms of sexual dysfunction (r+ = -.17). Openness was positively related to homosexual orientation (r+ = .16) and liberal attitudes toward sex (r+ = .19). Agreeableness and conscientiousness were negatively related to sexually aggressive behavior (r+ = -.20; r+ = -.14) and sexual infidelity (r+ = -.18; r+ = -.17). Less robust evidence indicated that extraversion related negatively, and neuroticism positively, to child sexual abuse, and that openness related negatively to homophobic attitudes. Random effects metaregression identified age, gender, and study quality as important moderators of pooled mean effects. These findings might be of interest to health care professionals developing health care services that aim to promote sexually healthy societies. (PsycINFO Database Record