Rabies Virus Glycoprotein

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Rabies Virus Glycoprotein
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Rabies Virus Glycoprotein, a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein, is only structural protein of the virus that induces the formation of virus-neutralizing antibodies and which confers immunity to animals.

Peptide Inhibitors
Catalog number
Molecular Formula
Molecular Weight
Rabies Virus Glycoprotein
White Lyophilized Powder
Store at -20°C
Soluble in Water, DMSO
1. The potential use of rabies virus glycoprotein-derived peptides to facilitate drug delivery into the central nervous system: a mini review
Susan Hawthorne, Paul McCarron, Rachel Huey J Drug Target . 2017 Jun;25(5):379-385. doi: 10.1080/1061186X.2016.1223676.
Rabies virus glycoprotein (RVG), a 505 amino acid type-1 glycoprotein, is responsible for the neurotrophic nature of the rabies virus infection. Despite varying reports in the literature as to which receptor is ultimately responsible for interaction of RVG with the nervous system, there is a strong argument for major nicotinic acetylcholine receptor (nAChR) involvement. Peptide derivatives of RVG, such as rabies virus-derived peptide (RDP) and RVG-29 are emerging as promising targeting ligands for the delivery of therapeutics to the central nervous system (CNS). The neurotrophic nature of RVG and indeed its derivatives may be due to interaction with ubiquitous nAChRs principally, but also association with other neural cell-specific molecules such as neural cell adhesion molecule (NCAM). It is possible that nAChR-mediated uptake of RVG-derived peptides may serve as an attractive new approach for targeting drug delivery to the brain. Potential application of this type of drug delivery system extends to many diseases affecting the CNS, where specific and effective drug delivery is normally a challenging process.
2. [Rabies virus glycoprotein: structure, immunogenicity and pathogenic role]
Andrés Ross B, Myriam Favi C, Abel Vásquez V Rev Chilena Infectol . 2008 Apr;25(2):S14-8.
Rabies glycoprotein is the only exposed protein which is inserted in the viral lipidie envelope. This 65-67 kda protein is a N-glycosilated transmembrane protein forming trimers on the viral surface. It has been identified as the major pathogenicity determinant, playing a role in the budding, viral axonal transport during infection, apoptosis and immune evasion. It is also the major antigen responsible for the protective immune response and it is been used in commercial recombinant vaccines. Its structure, antigenicity and pathogenic role have been well studied, identifying main antigenic sites that have the responsibility for virulence, cellular receptors attachment and epitope acquisition.
3. Targeted transport of nanocarriers into brain for theranosis with rabies virus glycoprotein-derived peptide
Yonggang Xiang, Ailing Fu, Chen Fu, Xiaorong Li Mater Sci Eng C Mater Biol Appl . 2018 Jun 1;87:155-166. doi: 10.1016/j.msec.2017.12.029.
For successful theranosis of brain diseases, limited access of therapeutic molecules across blood-brain barrier (BBB) needs be overcome in brain delivery. Currently, peptide derivatives of rabies virus glycoprotein (RVG) have been exploited as delivery ligands to transport nanocarriers across BBB and specifically into the brain. The targeting peptides usually conjugate to the nanocarrier surface, and the cargoes, including siRNA, miRNA, DNA, proteins and small molecular chemicals, are complexed or encapsulated in the nanocarriers. The peptide ligand of the RVG-modified nanocarriers introduces the conjugated targeted-delivery into the brain, and the cargoes are involved in disease theranosis. The peptide-modified nanocarriers have been applied to diagnose and treat various brain diseases, such as glioma, Alzheimer's disease, ischemic injury, protein misfolding diseases etc. Since the targeting delivery system has displayed good biocompatibility and desirable therapeutic effect, it will raise a potential application in treating brain diseases.

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