RVD-Hpα acetate
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RVD-Hpα acetate

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RVD-Hpα acetate is a neuropeptide that acts as a selective CB1 receptor agonist. It has been demonstrated to increase the phosphorylation of ERK1/2 levels or release of intracellular Ca2+. It is also a high-affinity CB2 positive allosteric modulator (Ki = 50 nM).

Category
Peptide Inhibitors
Catalog number
BAT-016438
Molecular Formula
C67H109N19O19
Molecular Weight
1484.71
RVD-Hpα acetate
IUPAC Name
acetic acid;(3S)-4-[(2S)-2-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-2-(1H-imidazol-5-yl)ethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-4-oxobutanoic acid
Synonyms
H-Arg-Val-Asp-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH.CH3CO2H; L-arginyl-L-valyl-L-alpha-aspartyl-L-prolyl-L-valyl-L-asparagyl-L-phenylalanyl-L-lysyl-L-leucyl-L-leucyl-L-seryl-L-histidine
Related CAS
1193362-76-3 (free base) 1431329-51-9 (TFA salt)
Purity
≥95%
Sequence
RVDPVNFKLLSH.CH3CO2H
Storage
Store at -20°C
Solubility
Soluble in Water
InChI
InChI=1S/C65H105N19O17.C2H4O2/c1-33(2)24-41(55(91)76-42(25-34(3)4)56(92)81-47(31-85)59(95)80-46(64(100)101)27-38-30-71-32-73-38)75-54(90)40(19-12-13-21-66)74-57(93)43(26-37-16-10-9-11-17-37)77-58(94)44(28-49(68)86)78-61(97)52(36(7)8)83-60(96)48-20-15-23-84(48)63(99)45(29-50(87)88)79-62(98)51(35(5)6)82-53(89)39(67)18-14-22-72-65(69)70;1-2(3)4/h9-11,16-17,30,32-36,39-48,51-52,85H,12-15,18-29,31,66-67H2,1-8H3,(H2,68,86)(H,71,73)(H,74,93)(H,75,90)(H,76,91)(H,77,94)(H,78,97)(H,79,98)(H,80,95)(H,81,92)(H,82,89)(H,83,96)(H,87,88)(H,100,101)(H4,69,70,72);1H3,(H,3,4)/t39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,51-,52-;/m0./s1
InChI Key
TXSNLJULGHHZBV-WRVANEEBSA-N
Canonical SMILES
CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)N)NC(=O)C(C(C)C)NC(=O)C3CCCN3C(=O)C(CC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)N.CC(=O)O
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