S-4-Methoxyltrityl-L-cysteine
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S-4-Methoxyltrityl-L-cysteine

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Category
L-Amino Acids
Catalog number
BAT-004189
CAS number
177582-20-6
Molecular Formula
C23H23NO3S
Molecular Weight
393.28
S-4-Methoxyltrityl-L-cysteine
IUPAC Name
(2R)-2-amino-3-[(4-methoxyphenyl)-diphenylmethyl]sulfanylpropanoic acid
Synonyms
L-Cys(Mmt)-OH; (2R)-2-Azanyl-3-[(4-Methoxyphenyl)-Diphenyl-Methyl]Sulfanyl-Propanoic Acid
Appearance
Off-white powder
Purity
≥ 97% (HPLC)
Melting Point
160-165 °C
Storage
Store at 2-8 °C
InChI
InChI=1S/C23H23NO3S/c1-27-20-14-12-19(13-15-20)23(17-8-4-2-5-9-17,18-10-6-3-7-11-18)28-16-21(24)22(25)26/h2-15,21H,16,24H2,1H3,(H,25,26)/t21-/m0/s1
InChI Key
QAINHNNAIDVCEZ-NRFANRHFSA-N
Canonical SMILES
COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)SCC(C(=O)O)N

S-4-Methoxyltrityl-L-cysteine, a protected amino acid derivative, plays a critical role in peptide synthesis. Here are four key applications:

Peptide Synthesis: Embracing S-4-Methoxyltrityl-L-cysteine as a pivotal component in solid-phase peptide synthesis elevates the precision of peptide assembly. Safeguarding the cysteine side chain guarantees the selective deprotection of functional groups, a crucial step in securing peptides of exceptional purity. This practice is indispensable in the realm of scientific inquiry, fueling the advancement of therapeutic peptide development and the exploration of protein functionalities with unwavering depth.

Drug Development: Within the domain of pharmaceutical research, the strategic use of this compound in peptide synthesis illuminates new pathways for drug discovery. By incorporating S-4-Methoxyltrityl-L-cysteine into synthetic frameworks, researchers can engineer peptides endowed with heightened stability and tailored pharmacological attributes. Such peptides emerge as promising candidates for drug development, serving as invaluable tools for uncovering and characterizing biological targets with unparalleled precision.

Bioconjugation: The strategic application of S-4-Methoxyltrityl-L-cysteine in bioconjugation methodologies revolutionizes the fusion of peptides or proteins with diverse molecular entities, including fluorophores, drugs, and polymers. The protective shield enveloping the cysteine residue orchestrates a symphony of controlled reactions, ensuring meticulous coupling processes with surgical precision. This orchestrated dance is essential for sculpting bioconjugates that power diagnostic assays, imaging techniques, and targeted therapeutics with finesse and ingenuity.

Protein Engineering: In the intricate landscape of protein engineering, S-4-Methoxyltrityl-L-cysteine emerges as a master orchestrator, facilitating the precise introduction of cysteine residues at tailored positions within proteins. This strategic maneuver empowers site-specific modifications, such as the formation of disulfide bonds or the attachment of functional groups, unlocking a realm of enhanced protein stability, activity, and functionality.

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