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S-Trityl-L-cysteine is a cell-permeable, potent and selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. S-Trityl-L-cysteine inhibits basal and microtubule-activated ATPase activity of Eg5 (IC50 = 1 mM and 140 nM, respectively). S-Trityl-L-cysteine was shown to induce mitotic arrest in HeLa cells with an IC50 of 700 nM.
S-Trityl-L-cysteine, a widely utilized chemical compound in bioscience research, exhibits specific inhibitory properties.
Cancer Research: Delving into the realms of cancer biology, S-Trityl-L-cysteine emerges as an indispensable inhibitor, honing in on mitotic kinesin Eg5. By precisely disrupting Eg5’s function, researchers unravel the intricacies of mitosis and uncover potential avenues for cancer therapies. This compound plays a pivotal role in dissecting the mechanisms driving cancer cell proliferation and evaluating anti-cancer compounds geared towards halting aberrant cell division.
Neuroscience Studies: Embark on a journey through the enigmatic world of neuroscience, where S-Trityl-L-cysteine acts as a catalyst for investigating neuronal cell cycle regulation and growth. Through targeted inhibition of Eg5, scientists probe the significance of mitosis in neural development and unravel the mysteries of neurodegeneration. This pioneering research opens doors to fresh insights into neurological disorders and propels the evolution of innovative treatment modalities.
Drug Development: Witness the transformative power of S-Trityl-L-cysteine as a trailblazing lead compound in the realm of targeted anti-cancer drug development. By scrutinizing its interactions with specific molecular targets, researchers craft derivatives with heightened efficacy and diminished side effects. This iterative process forms the cornerstone of propelling novel therapeutic agents through the intricate drug development pipeline.
Biochemistry Research: Embark on a voyage into the intricate landscape of biochemistry, where S-Trityl-L-cysteine serves as a beacon for unraveling protein-protein interactions and structural stability. Through selective inhibition of distinct proteins, scientists unveil their roles within cellular processes, shedding light on fundamental biological functions. This illuminative journey fuels the development of drugs tailored to target these intricate interactions, driving forward the frontier of biochemistry research and therapeutic innovation.
