S-Trityl-L-Cysteine tert-butyl ester hydrochloride
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S-Trityl-L-Cysteine tert-butyl ester hydrochloride

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A reactant in the development of a peptidomimetic ligand to be used in affinity chromatography.

Category
L-Amino Acids
Catalog number
BAT-002139
CAS number
158009-03-1
Molecular Formula
C26H30ClNO2S
Molecular Weight
456.00
IUPAC Name
tert-butyl (2R)-2-amino-3-tritylsulfanylpropanoate;hydrochloride
Synonyms
H-L-Cys(Trt)-OtBu HCl
Appearance
White powder
Purity
≥ 99% (HPLC)
Melting Point
68-74°C
Storage
Store at 2-8 °C
InChI
InChI=1S/C26H29NO2S.ClH/c1-25(2,3)29-24(28)23(27)19-30-26(20-13-7-4-8-14-20,21-15-9-5-10-16-21)22-17-11-6-12-18-22;/h4-18,23H,19,27H2,1-3H3;1H/t23-;/m0./s1
InChI Key
QPOWWSICTUFREA-BQAIUKQQSA-N
Canonical SMILES
CC(C)(C)OC(=O)C(CSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)N.Cl

S-Trityl-L-Cysteine tert-butyl ester hydrochloride, a specialized chemical compound, finds diverse applications in biochemical and medicinal research. Here are four key applications:

Protease Inhibition Studies: An invaluable tool in biochemical research, S-Trityl-L-Cysteine tert-butyl ester hydrochloride is frequently utilized to investigate protease inhibition. By serving as a potent inhibitor, it enables scientists to delve into the roles of specific proteases in cellular processes. This knowledge is paramount for unraveling disease mechanisms and advancing the development of protease-targeted therapies, shaping the landscape of cellular biology and treatment strategies.

Protein Synthesis Research: In the realm of protein synthesis, this compound plays a crucial role in modifying peptide and protein structures throughout the synthesis process. By safeguarding cysteine residues within proteins, S-Trityl-L-Cysteine tert-butyl ester hydrochloride ensures precise synthesis without undesirable side reactions, fostering the production of high-purity peptides and proteins for a wide array of research and therapeutic applications, driving innovation in protein science and drug design.

Drug Development: At the forefront of drug development, S-Trityl-L-Cysteine tert-butyl ester hydrochloride is a key player in the evaluation and testing of novel therapeutic agents. Researchers employ this compound to assess the pharmacokinetics and stability of potential drugs, especially those targeting cysteine residues. This contributes to the optimization of drug candidates and the enhancement of novel therapies’ efficacy, reshaping the landscape of pharmaceutical research and therapeutic innovation.

Chemical Biology: A valuable asset in the field of chemical biology, this compound enriches our understanding of cysteine residues’ reactivity and functionality within proteins. By selectively interacting with these residues, scientists gain profound insights into protein structure and function, unveiling new potential drug targets and deciphering the molecular underpinnings of various diseases. These studies are pivotal for advancing drug discovery efforts and deepening our comprehension of disease pathways, propelling the frontier of molecular and cellular biology forward.

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