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(Sar1)-Angiotensin II acetate

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(Sar1)-Angiotensin II acetate is a specific agonist of the angiotensin AT1 receptor that binds to brain membrane-rich particles, with a Kd of 2.7 nM. (Sar1)-Angiotensin II acetate can stimulate protein synthesis and cell growth in embryonic chick myocytes.

Category

Peptide Inhibitors

Catalog number

BAT-016352

CAS number

2863657-02-5

Molecular Formula

C51H75N13O12

Molecular Weight

1062.22

Specification

IUPAC Name

acetic acid;(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid

Synonyms

H-Sar-Arg-Val-Tyr-Ile-His-Pro-Phe-OH.CH3CO2H; sarcosyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine acetic acid

Related CAS

51833-69-3 (free base) 102029-89-0 (diacetate salt) 1033008-45-5 (dihydrochloride) 1033008-71-7 (trihydrochloride)

Purity

≥95%

Sequence

Sar-RVYIHPF.CH3CO2H

Storage

Store at -20°C

Solubility

Soluble in DMSO

InChI

InChI=1S/C49H71N13O10.C2H4O2/c1-6-29(4)41(46(69)58-36(24-32-25-53-27-55-32)47(70)62-21-11-15-38(62)44(67)59-37(48(71)72)23-30-12-8-7-9-13-30)61-43(66)35(22-31-16-18-33(63)19-17-31)57-45(68)40(28(2)3)60-42(65)34(56-39(64)26-52-5)14-10-20-54-49(50)51;1-2(3)4/h7-9,12-13,16-19,25,27-29,34-38,40-41,52,63H,6,10-11,14-15,20-24,26H2,1-5H3,(H,53,55)(H,56,64)(H,57,68)(H,58,69)(H,59,67)(H,60,65)(H,61,66)(H,71,72)(H4,50,51,54);1H3,(H,3,4)/t29-,34-,35-,36-,37-,38-,40-,41-;/m0./s1

InChI Key

VIPLPZKDKSDVMT-HVFSHKBNSA-N

Canonical SMILES

CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)CNC.CC(=O)O