[Sar1,Ile8]-Angiotensin II TFA
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[Sar1,Ile8]-Angiotensin II TFA

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[Sar1,Ile8]-Angiotensin II TFA is a specific antagonist of angiotensin receptor, and it is also a peptide that has multiple effect on vascular smooth muscle.

Category
Peptide Inhibitors
Catalog number
BAT-009154
CAS number
2918768-31-5
Molecular Formula
C46H73N13O10.C2HF3O2
Molecular Weight
1082.18
[Sar1,Ile8]-Angiotensin II TFA
IUPAC Name
(2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoic acid;2,2,2-trifluoroacetic acid
Synonyms
[Sar1,Ile8]-Angiotensin II TFA; N-Methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-isoleucine TFA; [Sar1-Ile5-Ile8]-angiotensin II TFA; [Sarcosyl1-Ile5-Ile8]-angiotensin II TFA; Sarilesin TFA; Angiotensin 2 TFA; H-Sar-Arg-Val-Tyr-Ile-His-Pro-Ile-OH.TFA; sarcosyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-isoleucine trifluoroacetic acid
Related CAS
37827-06-8 (free base) 67724-27-0 (acetate salt)
Appearance
Powder
Purity
>98%
Sequence
Sar-RVYIHPI.TFA
Storage
Store at -20°C
Solubility
Soluble in Water
InChI
InChI=1S/C46H73N13O10.C2HF3O2/c1-8-26(5)37(43(66)55-33(21-29-22-50-24-52-29)44(67)59-19-11-13-34(59)41(64)58-38(45(68)69)27(6)9-2)57-40(63)32(20-28-14-16-30(60)17-15-28)54-42(65)36(25(3)4)56-39(62)31(53-35(61)23-49-7)12-10-18-51-46(47)48;3-2(4,5)1(6)7/h14-17,22,24-27,31-34,36-38,49,60H,8-13,18-21,23H2,1-7H3,(H,50,52)(H,53,61)(H,54,65)(H,55,66)(H,56,62)(H,57,63)(H,58,64)(H,68,69)(H4,47,48,51);(H,6,7)/t26-,27-,31-,32-,33-,34-,36-,37-,38-;/m0./s1
InChI Key
CRMJFLJNJDPPTM-OFHYUQTQSA-N
Canonical SMILES
CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(C(C)CC)C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)CNC.C(=O)(C(F)(F)F)O
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