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[Sar9] Substance P acetate

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

[Sar9]-Substance P acetate is a potent and selective neurokinin (NK)-1 receptor agonist. The effect of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.

Category

Peptide Inhibitors

Catalog number

BAT-016444

Molecular Formula

C66H104N18O15S

Molecular Weight

1421.71

Specification

IUPAC Name

acetic acid;(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide

Synonyms

Substance P, 9-(N-methylglycine)-, acetate (1:1); 9-(N-Methylglycine)substance P acetate; [MeGly9]-substance P acetate; H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met-NH2.CH3CO2H; L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanyl-sarcosyl-L-leucyl-L-methioninamide acetate

Related CAS

77128-75-7 (free base)

Purity

≥95%

Sequence

RPKPQQFFXLM-NH2.CH3CO2H (Modifications: X-9 = Sar)

Storage

Store at -20°C

Solubility

Soluble in DMSO

InChI

InChI=1S/C64H100N18O13S.C2H4O2/c1-38(2)34-46(57(89)74-42(54(69)86)28-33-96-4)73-53(85)37-80(3)62(94)48(36-40-18-9-6-10-19-40)79-58(90)47(35-39-16-7-5-8-17-39)78-56(88)43(24-26-51(67)83)75-55(87)44(25-27-52(68)84)76-59(91)50-23-15-32-82(50)63(95)45(21-11-12-29-65)77-60(92)49-22-14-31-81(49)61(93)41(66)20-13-30-72-64(70)71;1-2(3)4/h5-10,16-19,38,41-50H,11-15,20-37,65-66H2,1-4H3,(H2,67,83)(H2,68,84)(H2,69,86)(H,73,85)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,88)(H,79,90)(H4,70,71,72);1H3,(H,3,4)/t41-,42-,43-,44-,45-,46-,47-,48-,49-,50-;/m0./s1

InChI Key

LEPDRMGLNBWHJE-LYQMAKBCSA-N

Canonical SMILES

CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CN(C)C(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)N.CC(=O)O