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SARS-CoV-2 Spike RBM (receptor binding motif) 500-509 is the 500-509 amino acid residue of SARS-CoV-2 Spike RBM (receptor binding motif), the main functional motif in RBD. SARS-CoV-2 Spike RBM is composed of two regions (region 1 and region 2) that form the interface of the S protein with hACE2.