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Secretin Acetate

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Secretin is a hormone secreted by the wall of the upper part of the small intestine (the duodenum). It is released in response to acid in the small intestine to regulate gastric acid secretion and pH levels in the duodenum.

Category

Peptide Inhibitors

Catalog number

BAT-006120

CAS number

10813-74-8

Molecular Formula

C130H220N44O41

Molecular Weight

3115.49

Size	Price	Stock	Quantity
2.5 mg	$239	In stock
5 mg	$419	In stock

Specification
Reference Reading

IUPAC Name

acetic acid;5-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[1-[[5-amino-1-[[1-[[1-[[1-[[5-amino-1-[[2-[[1-[(1-amino-3-methyl-1-oxobutan-2-yl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoic acid

Synonyms

His-Ser-Asp-Gly-Thr-Phe-Thr- Ser-Glu-Leu-Ser-Arg-Leu-Arg- Glu-Gly-Ala-Arg-Leu-Gln-Arg- Leu-Leu-Gln-Gly-Leu-Val-NH2

Related CAS

17034-35-4 17034-34-3

Purity

98%

Sequence

HSDGTFTSELSRLRDSARLQRLLQGLV

Storage

Store at -20°C

InChI

InChI=1S/C130H220N44O41.C2H4O2/c1-59(2)41-79(119(208)173-99(65(13)14)102(134)191)152-94(183)52-148-105(194)76(31-34-92(132)181)157-114(203)82(44-62(7)8)164-116(205)83(45-63(9)10)162-108(197)73(28-22-38-145-128(137)138)154-111(200)77(32-35-93(133)182)158-115(204)81(43-61(5)6)160-107(196)72(27-21-37-144-127(135)136)153-103(192)66(15)151-121(210)88(54-175)169-118(207)87(50-98(189)190)166-110(199)74(29-23-39-146-129(139)140)155-113(202)80(42-60(3)4)161-109(198)75(30-24-40-147-130(141)142)156-122(211)90(56-177)170-117(206)84(46-64(11)12)163-112(201)78(33-36-96(185)186)159-123(212)91(57-178)171-126(215)101(68(17)180)174-120(209)85(47-69-25-19-18-20-26-69)167-125(214)100(67(16)179)172-95(184)53-149-106(195)86(49-97(187)188)165-124(213)89(55-176)168-104(193)71(131)48-70-51-143-58-150-70;1-2(3)4/h18-20,25-26,51,58-68,71-91,99-101,175-180H,21-24,27-50,52-57,131H2,1-17H3,(H2,132,181)(H2,133,182)(H2,134,191)(H,143,150)(H,148,194)(H,149,195)(H,151,210)(H,152,183)(H,153,192)(H,154,200)(H,155,202)(H,156,211)(H,157,203)(H,158,204)(H,159,212)(H,160,196)(H,161,198)(H,162,197)(H,163,201)(H,164,205)(H,165,213)(H,166,199)(H,167,214)(H,168,193)(H,169,207)(H,170,206)(H,171,215)(H,172,184)(H,173,208)(H,174,209)(H,185,186)(H,187,188)(H,189,190)(H4,135,136,144)(H4,137,138,145)(H4,139,140,146)(H4,141,142,147);1H3,(H,3,4)/t66-,67+,68+,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,99-,100-,101-;/m0./s1

InChI Key

VVFCPAYEMPIQMB-YVTYOULFSA-N

Canonical SMILES

CC(C)CC(C(=O)NC(C(C)C)C(=O)N)NC(=O)CNC(=O)C(CCC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(CC2=CNC=N2)N.CC(=O)O

1.The Src kinase Yes is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters, but not pancreatic growth factors, which stimulate its association with numerous other signaling molecules.

Sancho V1, Nuche-Berenguer B, Jensen RT. Biochim Biophys Acta. 2012 Aug;1823(8):1285-94. doi: 10.1016/j.bbamcr.2012.05.015. Epub 2012 May 19.

For growth factors, cytokines, G-protein-coupled receptors and numerous other stimuli, the Src Family of kinases (SFK) play a central signaling role. SFKs also play an important role in pancreatic acinar cell function including metabolism, secretion, endocytosis, growth and cytoskeletal integrity, although the specific SFKs involved are not fully known. In the present study we used specific antibodies for the SFK, Yes, to determine its presence, activation by pancreatic secretagogues or growth factors, and interaction with cellular signaling cascades mediated by CCK in which Yes participates in to cause acinar cell responses. Yes was identified in acini and secretagogues known to activate phospholipase C (PLC) [CCK, carbachol, bombesin] as well as post-receptor stimulants activating PKC [TPA] or mobilizing cellular calcium [thapsigargin/calcium ionophore (A23187)] each activated Yes. Secretin, which activates adenylate cyclase did not stimulate Yes, nor did pancreatic growth factors.

2.Dibutyltin dichloride modifies amylase release from isolated rat pancreatic acini.

Nagashio Y1, Hirohata Y, Akiyama T, Otsuki M. Pancreas. 2002 Jul;25(1):57-62.

INTRODUCTION: Dibutyltin dichloride (DBTC) is widely used as a stabilizer for polyvinylchloride plastics and is of particular toxicologic interest.

3.An Exocrine Pancreatic Stress Test with (11)C-Acetate PET and Secretin Stimulation.

Hyun O J1, Lodge MA1, Jagannath S2, Buscaglia JM3, Olagbemiro Y1, Wahl RL4. J Nucl Med. 2014 Jul;55(7):1128-31. doi: 10.2967/jnumed.113.135681. Epub 2014 May 19.

The purpose of this study was to develop a noninvasive imaging test of pancreatic exocrine function.

4.Mechanisms of gastric mucus secretion from cultured rat gastric epithelial cells induced by carbachol, cholecystokinin octapeptide, secretin, and prostaglandin E2.

Tani S1, Suzuki T, Kano S, Tanaka T, Sunaga K, Morishige R, Tsuda T. Biol Pharm Bull. 2002 Jan;25(1):14-8.

The effects of carbachol, cholecystokinin octapeptide (CCK-8), secretin, prostaglandin E2 (PGE2), and second mediator-like substances (A23187, phorbol 12-myristate 13-acetate, and dibutyryl cAMP) on mucus secretion from cultured gastric epithelial cells were investigated. Gastric mucus was measured by an enzyme-linked lectin assay with soybean agglutinin and wheat germ agglutinin. Intracellular cAMP and Ca2+ were measured with a cAMP assay kit and an image analysis system using fura-2-loaded cells, respectively. Secreted mucus induced by any combination of receptor agonists was almost equal to the summation of each stimulated mucus secretion. On the other hand, combined stimulation with second mediator-like substances secreted mucus synergistically. These results suggest the existence of interactions among receptors for mucus secretion. Based on these results, the secretagogue induced intracellular cAMP and free calcium ([Ca2+]i) levels were measured in cultured gastric epithelial cells incubated with secretagogues.