In the treatment of neuroendocrine tumors (NET), complete surgical removal of malignancy is generally desirable, as it offers curative results. Pre-operative guidance with radiolabeled somatostatin analogues, commonly used for NET diagnosis and pre-operative planning, is limited by its low resolution, with the risk that tumor margins and small metastases will be incompletely resected with subsequent recurrence. A single hybrid probe combining radiotracer and optical dye would enable high-resolution optical guidance, also during surgery. In the current study, the hybrid labeled somatostatin analogue Cy5-DTPA-Tyr3-octreotate was synthesized and evaluated for its ability to specifically trace NET cells in vitro and in an animal model. The performance of the hybrid tracer was compared to that of octreotate with only radiolabel or only optical label.

OBJECTIVE: The objective of this study is to evaluate the efficacy of somatostatin, ulinastatin and gabexate for the treatment of severe acute pancreatitis.