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Suc-Ala-Phe-Lys-AMC

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Suc-Ala-Phe-Lys-AMC is a highly sensitive fluorogenic substrate for plasmin, and is used for determination of gingipain K.

Category

Others

Catalog number

BAT-015206

CAS number

73207-91-7

Molecular Formula

C32H39N5O8

Molecular Weight

621.69

Specification
Reference Reading

IUPAC Name

4-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid

Synonyms

Suc-AFK-AMC; N-(3-Carboxy-1-oxopropyl)-L-alanyl-L-phenylalanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide; N-Succinyl-Ala-Phe-Lys-MCA; L-Lysinamide, N-(3-carboxy-1-oxopropyl)-L-alanyl-L-phenylalanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-; 4-(((S)-1-(((S)-1-(((S)-6-amino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxohexan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)amino)-4-oxobutanoic acid

Appearance

White Powder

Purity

95%

Density

1.3±0.1 g/cm3

Boiling Point

1039.6±65.0°C at 760 mmHg

Storage

Store at -20°C

Solubility

Soluble in DMSO

InChI

InChI=1S/C32H39N5O8/c1-19-16-29(41)45-26-18-22(11-12-23(19)26)35-31(43)24(10-6-7-15-33)36-32(44)25(17-21-8-4-3-5-9-21)37-30(42)20(2)34-27(38)13-14-28(39)40/h3-5,8-9,11-12,16,18,20,24-25H,6-7,10,13-15,17,33H2,1-2H3,(H,34,38)(H,35,43)(H,36,44)(H,37,42)(H,39,40)/t20-,24-,25-/m0/s1

InChI Key

GAQKKPHZOUJFMZ-OPXMRZJTSA-N

Canonical SMILES

CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CCCCN)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(C)NC(=O)CCC(=O)O

1.Unravelling the mechanism of the interactions of oxazolidine A and E with collagens in ovine skin.

Choudhury SD1, DasGupta S, Norris GE. Int J Biol Macromol. 2007 Mar 10;40(4):351-61. Epub 2006 Oct 20.

Cross-linking agents play an important part in the physical properties of collagen based biomaterials. Oxazolidines are novel aldehydic tanning agents that are widely used to stabilise collagens in the leather industry. The exact mechanism through which they cross-link collagens is, however, not well understood. When they are combined with vegetable tannins, it is thought that oxazolidines form carbocationic intermediates through ring opening, which are then able to interact with the amino acid side chains of collagens and flavonoid ring systems of vegetable tannins. In this study, the interactions of oxazolidines, with collagens, have been investigated using a number of analytical techniques. High pressure liquid chromatography (HPLC) analysis of oxazolidine tanned collagen samples showed that there is an irreversible reaction with tyrosine side chains. Mass spectrometry (MS) revealed the formation of a Schiff's base adduct with lysine residues, which was reversible in nature.