Need Assistance?
  • US & Canada:
    +
  • UK: +

TDFA

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

TDFA is a protein arginine deiminase 4 (PAD4) inhibitor (IC50 = 2.3, 8.5, 26 and 71 μM for PAD4, PAD1, PAD3 and PAD2, respectively) used for the treatment of autoimmune disorders.

Category
Peptide Inhibitors
Catalog number
BAT-010308
CAS number
1345019-64-8
Molecular Formula
C17H29FN6O7
Molecular Weight
448.45
TDFA
IUPAC Name
(3S)-3-[[(2S,3R)-2-acetamido-3-hydroxybutanoyl]amino]-4-[[(2S)-1-amino-5-[(1-amino-2-fluoroethylidene)amino]-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
Synonyms
(3S)-3-[[(2S,3R)-2-acetamido-3-hydroxybutanoyl]amino]-4-[[(2S)-1-amino-5-[(1-amino-2-fluoroethylidene)amino]-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
Density
1.5±0.1 g/cm3
Sequence
Ac-Thr-Asp-Orn(Unk)-NH2
Storage
Store at -20°C
InChI
InChI=1S/C17H29FN6O7/c1-8(25)14(22-9(2)26)17(31)24-11(6-13(27)28)16(30)23-10(15(20)29)4-3-5-21-12(19)7-18/h8,10-11,14,25H,3-7H2,1-2H3,(H2,19,21)(H2,20,29)(H,22,26)(H,23,30)(H,24,31)(H,27,28)/t8-,10+,11+,14+/m1/s1
InChI Key
SOZMHIJABUOUSN-ORMVGFHCSA-N
Canonical SMILES
CC(C(C(=O)NC(CC(=O)O)C(=O)NC(CCCN=C(CF)N)C(=O)N)NC(=O)C)O
1.Association of protein structure, protein and carbohydrate subfractions with bioenergy profiles and biodegradation functions in modeled forage.
Ji C;Zhang X;Yu P Spectrochim Acta A Mol Biomol Spectrosc. 2016 Mar 15;157:265-270. doi: 10.1016/j.saa.2015.11.017. Epub 2015 Dec 1.
The objectives of this study were to detect unique aspects and association of forage protein inherent structure, biological compounds, protein and carbohydrate subfractions, bioenergy profiles, and biodegradation features. In this study, common available alfalfa hay from two different sourced-origins (FSO vs. CSO) was used as a modeled forage for inherent structure profile, bioenergy, biodegradation and their association between their structure and bio-functions. The molecular spectral profiles were determined using non-invasive molecular spectroscopy. The parameters included: protein structure amide I group, amide II group and their ratios; protein subfractions (PA1, PA2, PB1, PB2, PC); carbohydrate fractions (CA1, CA2, CA3, CA4, CB1, CB2, CC); biodegradable and undegradable fractions of protein (RDPA2, RDPB1, RDPB2, RDP; RUPA2 RUPB1, RUPB2, RUPC, RUP); biodegradable and undegradable fractions of carbohydrate (RDCA4, RDCB1, RDCB2, RDCB3, RDCHO; RUCA4, RUCB1; RUCB2; RUCB3 RUCC, RUCHO) and bioenergy profiles (tdNDF, tdFA, tdCP, tdNFC, TDN1×, DE3×, ME3×, NEL3×; NEm, NEg). The results show differences in protein and carbohydrate (CHO) subfractions in the moderately degradable true protein fraction (PB1: 502 vs.
2.1.9-3.6  μm supercontinuum generation in a very short highly nonlinear germania fiber with a high mid-infrared power ratio.
Yin K;Zhang B;Yao J;Yang L;Liu G;Hou J Opt Lett. 2016 Nov 1;41(21):5067-5070. doi: 10.1364/OL.41.005067.
In this Letter, a high-power supercontinuum (SC) laser source which spanned from 1.9 to 3.6 μm with an all-fiber configuration was reported. This SC laser was obtained by concatenating a thulium-doped fiber amplifier (TDFA) and a 12 cm long highly nonlinear germania fiber. A 1.9-2.7 μm SC laser from the TDFA was spectrally broadened continuously into the mid-infrared region (>3  μm) in the following germania fiber. When the repetition rate was 2 MHz, the obtained SC laser had a maximum output power of 6.12 W with an optical conversion efficiency of 15.3% with respect to the TDFA pump power. The SC laser had a spectral bandwidth of 1506 nm ranging from 1944 to 3450 nm at the -20  dB level. The SC power with wavelengths >3  μm was 2.9 W, corresponding to a high power ratio of 47.4% in the mid-infrared region. The achieved power ratio in the mid-infrared region, as well as the long wavelength cutoff, to the best of our knowledge, were the best results ever reported in germania fibers.
3.Ultrahigh-brightness, spectrally-flat, short-wave infrared supercontinuum source for long-range atmospheric applications.
Yin K;Zhu R;Zhang B;Jiang T;Chen S;Hou J Opt Express. 2016 Sep 5;24(18):20010-20. doi: 10.1364/OE.24.020010.
Fiber based supercontinuum (SC) sources with output spectra covering the infrared atmospheric window are very useful in long-range atmospheric applications. It is proven that silica fibers can support the generation of broadband SC sources ranging from the visible to the short-wave infrared region. In this paper, we present the generation of an ultrahigh-brightness spectrally-flat 2-2.5 μm SC source in a cladding pumped thulium-doped fiber amplifier (TDFA) numerically and experimentally. The underlying physical mechanisms behind the SC generation process are investigated firstly with a numerical model which includes the fiber gain and loss, the dispersive and nonlinear effects. Simulation results show that abundant soliton pulses are generated in the TDFA, and they are shifted towards the long wavelength side very quickly with the nonlinearity of Raman soliton self-frequency shift (SSFS), and eventually the Raman SSFS process is halted due to the silica fiber's infrared loss. A spectrally-flat 2-2.5 μm SC source could be generated as the result of the spectral superposition of these abundant soliton pulses. These simulation results correspond qualitatively well to the following experimental results.
Online Inquiry
Verification code
Inquiry Basket