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(Thr(PO3H2)231)-Tau Peptide (225-237)

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Trans-cis-conversion of the pThr231-Pro232 motif has been observed in the early stages of Alzheimer's disease. Pin1 prevents the accumulation of the resulting pathogenic form of tau by reversing isomerization.

Category

Functional Peptides

Catalog number

BAT-014641

CAS number

1670270-09-3

Molecular Formula

C61H109N18O20P

Molecular Weight

1445.60

Specification

IUPAC Name

(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[(2S)-1-[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phosphonooxybutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoic acid

Synonyms

Phosphorylated Thr231-Pro Tau; H-Lys-Val-Ala-Val-Val-Arg-Thr(PO3H2)-Pro-Pro-Lys-Ser-Pro-Ser-OH; L-Lysyl-L-valyl-L-alanyl-L-valyl-L-valyl-L-arginyl-[O-phosphono-L-threonyl]-L-prolyl-L-prolyl-L-lysyl-L-seryl-L-prolyl-L-serine

Appearance

White Powder

Purity

≥95%

Density

1.51±0.1 g/cm3

Sequence

KVAVVRT(PO3H2)PPKSPS

Storage

Store at -20°C

Solubility

Soluble in DMSO, Water

InChI

InChI=1S/C61H109N18O20P/c1-31(2)44(74-49(83)36(64)17-9-11-23-62)54(88)68-34(7)48(82)73-46(33(5)6)56(90)75-45(32(3)4)55(89)70-38(19-13-25-67-61(65)66)51(85)76-47(35(8)99-100(96,97)98)59(93)79-28-16-22-43(79)58(92)78-27-15-21-42(78)52(86)69-37(18-10-12-24-63)50(84)71-39(29-80)57(91)77-26-14-20-41(77)53(87)72-40(30-81)60(94)95/h31-47,80-81H,9-30,62-64H2,1-8H3,(H,68,88)(H,69,86)(H,70,89)(H,71,84)(H,72,87)(H,73,82)(H,74,83)(H,75,90)(H,76,85)(H,94,95)(H4,65,66,67)(H2,96,97,98)/t34-,35+,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1

InChI Key

NCUXLCILHBVVMR-ARRDLYBBSA-N

Canonical SMILES

CC(C)C(C(=O)NC(C(C)C)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)OP(=O)(O)O)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)N3CCCC3C(=O)NC(CO)C(=O)O)NC(=O)C(C)NC(=O)C(C(C)C)NC(=O)C(CCCCN)N