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Thrombospondin-1 (1016-1023) (human, bovine, mouse)

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Thrombospondin-1 (1016-1023) (human, bovine, mouse) is an octapeptide that constitutes the active sequence within the 30-mer peptide named C4, because it is essential for TS1 CBD cell attachment activity. It supports the attachment of G361 melanoma cells and inhibits their adherence to the rec CBD of TS1. In addition, It appears to be highly conserved in all TS1 subtypes, and a related sequence also presents in the F9 fragment of laminin. 4N1 has been used as a CD47 agonist.

Category

Peptide Inhibitors

Catalog number

BAT-014452

CAS number

149234-04-8

Molecular Formula

C56H81N13O10S

Molecular Weight

1128.39

Specification

IUPAC Name

(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoic acid

Synonyms

TS1 (1016-1023) (human, bovine, mouse); H-Arg-Phe-Tyr-Val-Val-Met-Trp-Lys-OH; L-arginyl-L-phenylalanyl-L-tyrosyl-L-valyl-L-valyl-L-methionyl-L-tryptophyl-L-lysine; N5-(Diaminomethylene)-L-ornithyl-L-phenylalanyl-L-tyrosyl-L-valyl-L-valyl-L-methionyl-L-tryptophyl-L-lysine

Appearance

White Powder

Purity

≥95% by HPLC

Density

1.36±0.1 g/cm3

Sequence

RFYVVMWK

Storage

Store at -20°C

Solubility

Soluble in Water

InChI

InChI=1S/C56H81N13O10S/c1-32(2)46(53(76)63-41(24-27-80-5)49(72)67-45(30-36-31-62-40-18-10-9-16-38(36)40)51(74)64-42(55(78)79)19-11-12-25-57)69-54(77)47(33(3)4)68-52(75)44(29-35-20-22-37(70)23-21-35)66-50(73)43(28-34-14-7-6-8-15-34)65-48(71)39(58)17-13-26-61-56(59)60/h6-10,14-16,18,20-23,31-33,39,41-47,62,70H,11-13,17,19,24-30,57-58H2,1-5H3,(H,63,76)(H,64,74)(H,65,71)(H,66,73)(H,67,72)(H,68,75)(H,69,77)(H,78,79)(H4,59,60,61)/t39-,41-,42-,43-,44-,45-,46-,47-/m0/s1

InChI Key

OBPWCMITEMLEAX-MGQPXDLZSA-N

Canonical SMILES

CC(C)C(C(=O)NC(C(C)C)C(=O)NC(CCSC)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CCCN=C(N)N)N