1.Gonadotrophin-releasing hormone agonist protocols for pituitary suppression in assisted reproduction.
Siristatidis CS1, Gibreel A, Basios G, Maheshwari A, Bhattacharya S. Cochrane Database Syst Rev. 2015 Nov 9;11:CD006919. doi: 10.1002/14651858.CD006919.pub4.
BACKGROUND: Gonadotrophin-releasing hormone agonists (GnRHa) are commonly used in assisted reproduction technology (ART) cycles to prevent a luteinising hormone surge during controlled ovarian hyperstimulation (COH) prior to planned oocyte retrieval, thus optimising the chances of live birth.
2.Efficacy of triptorelin pamoate 11.25 mg administered subcutaneously for achieving medical castration levels of testosterone in patients with locally advanced or metastatic prostate cancer.
Lebret T1, Rouanne M1, Hublarov O2, Jinga V3, Petkova L4, Kotsev R5, Sinescu I6, Dutailly P7. Ther Adv Urol. 2015 Jun;7(3):125-34. doi: 10.1177/1756287215577329.
OBJECTIVES: Gonadotropin-releasing hormone agonists are widely used as androgen deprivation therapy in many men with locally advanced or metastatic prostate cancer. Gonadotropin-releasing hormone agonists are delivered by intramuscular injection every 1, 3 or 6 months, but in some patients subcutaneous injection may be more appropriate. This study assessed the efficacy and safety profile of the gonadotropin-releasing hormone agonist, triptorelin pamoate, when administered by the subcutaneous route.
3.Long-term contraception in a small implant: A review of Suprelorin (deslorelin) studies in cats.
Fontaine C1. J Feline Med Surg. 2015 Sep;17(9):766-71. doi: 10.1177/1098612X15594990.
RATIONALE: Deslorelin (Suprelorin®; Virbac) is a gonadotropin-releasing hormone (GnRH) agonist licensed in select countries for the long-term suppression of fertility in adult male dogs and male ferrets. This article summarizes studies investigating the use of deslorelin implants for the long-term suppression of fertility in male and female domestic cats.
4.MEDICAL MANAGEMENT OF LEIOMYOMATA AND SUSPECTED ENDOMETRIOSIS IN AN ALLEN'S SWAMP MONKEY (ALLENOPITHECUS NIGROVIRIDUS).
Jafarey YS, Hanley CS, Berlinski RA, Warner C, Armstrong A. J Zoo Wildl Med. 2015 Dec;46(4):913-7. doi: 10.1638/2014-0224.1.
A 13-yr-old female nulliparous Allen's swamp monkey (Allenopitchecus nigroviridis) presented with intermittent excessive vaginal bleeding, cyclical lethargy, and a history of irregular menstrual cycles. Abdominal ultrasonography revealed a subjectively thickened, irregular endometrium, multiple leiomyomata (uterine fibroids), and bilateral anechoic foci on the ovaries. Treatment was initiated with leuprolide acetate i.m. monthly for 6 mo. Recheck ultrasound at 3 mo showed a decrease in leiomyoma diameter and no evidence of active follicles on the ovaries. Eleven months following completion of treatment, clinical signs recurred and the animal was treated with a deslorelin implant. Since implant placement, no vaginal bleeding has been noted.