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Trt-Cysteamine HCl

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

S-Tritylcysteamine Hydrochloride has been shown to have an antileukemic activity.

Category

Amino Alcohol

Catalog number

BAT-002634

CAS number

15297-43-5

Molecular Formula

C21H21NS·HCl

Molecular Weight

355.92

IUPAC Name

2-tritylsulfanylethanamine;hydrochloride

Synonyms

2-tritylsulfanylethanamine,hydrochloride; S-tritylcysteamine HCl; S-trityl-D-cysteine; S-tritylcysteamine hydrochloride; S-trityl-2-mercaptoethylamine hydrochloride

Purity

≥ 95%

InChI

InChI=1S/C21H21NS.ClH/c22-16-17-23-21(18-10-4-1-5-11-18,19-12-6-2-7-13-19)20-14-8-3-9-15-20;/h1-15H,16-17,22H2;1H

InChI Key

SLSXAHLRIYRHBE-UHFFFAOYSA-N

Canonical SMILES

C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)SCCN.Cl

Trt-Cysteamine HCl is a compound with a broad spectrum of applications in medical and research fields. Here are some key applications of Trt-Cysteamine HCl:

Cystinosis Treatment: Trt-Cysteamine HCl is chiefly used in the treatment of cystinosis, a rare metabolic disorder characterized by the accumulation of cystine within cells. By facilitating the breakdown of cystine, Trt-Cysteamine HCl helps reduce the formation of cystine crystals, thereby preventing organ damage. It is administered to patients as an oral medication to manage this lifelong chronic condition.

Neuroprotection: Trt-Cysteamine HCl has shown potential in protecting neurons against oxidative stress and injury. In neurodegenerative disease models, such as Parkinson’s and Huntington’s diseases, it has been demonstrated to reduce cellular damage and enhance neuronal survival. This neuroprotective property makes it a candidate for therapeutic applications aimed at mitigating neurodegenerative symptoms.

Antioxidant Research: As an antioxidant, Trt-Cysteamine HCl is useful in scientific research aimed at understanding oxidative stress mechanisms. Researchers utilize this compound to study its effects on cellular redox states and the modulation of oxidative pathways. These studies are integral to developing new therapies for diseases related to oxidative damage, including cancer and cardiovascular diseases.

Gene Expression Analysis: Trt-Cysteamine HCl is utilized in gene expression studies to investigate its role in the regulation of specific genes. By treating cells with this compound, researchers can observe changes in gene transcription and resultant protein expression. This application is critical for deciphering gene functions and discovering potential biomarkers for various diseases.

1. Standardized Hybrid Closed-Loop System Reporting

Viral N Shah, Satish K Garg Diabetes Technol Ther. 2021 May;23(5):323-331. doi: 10.1089/dia.2020.0622. Epub 2020 Nov 25.

The hybrid closed-loop (HCL) system has been shown to improve glycemic control and reduce hypoglycemia. Optimization of HCL settings requires interpretation of the glucose, insulin, and factors affecting glucose such as food intake and exercise. To the best of our knowledge, there is no published guidance on the standardized reporting of HCL systems. Standardization of HCL reporting would make interpretation of data easy across different systems. We reviewed the literature on patient and provider perspectives on downloading and reporting glucose metric preferences. We also incorporated international consensus on standardized reporting for glucose metrics. We describe a single-page HCL data reporting, referred to here as "artificial pancreas (AP) Dashboard." We propose seven components in the AP Dashboard that can provide detailed information and visualization of glucose, insulin, and HCL-specific metrics. The seven components include (A) glucose metrics, (B) hypoglycemia, (C) insulin, (D) user experience, (E) hyperglycemia, (F) glucose modal-day profile, and (G) insight. A single-page report similar to an electrocardiogram can help providers and patients interpret HCL data easily and take the necessary steps to improve glycemic outcomes. We also describe the optimal sampling duration for HCL data download and color coding for visualization ease. We believe that this is a first step in creating a standardized HCL reporting, which may result in better uptake of the systems. For increased adoption, standardized reporting will require input from providers, patients, diabetes device manufacturers, and regulators.

2. Biology and Treatment of Hairy Cell Leukemia

Jérôme Paillassa, Xavier Troussard Curr Treat Options Oncol. 2020 Apr 30;21(6):44. doi: 10.1007/s11864-020-00732-0.

Despite its rarity, hairy cell leukemia (HCL) remains a fascinating disease and the physiopathology is becoming more and more understood. The accurate diagnosis of HCL relies on the recognition of hairy cells by morphology and flow cytometry (FCM) in the blood and/or bone marrow (BM). The BRAF V600E mutation, an HCL-defining mutation, represents a novel diagnostic parameter and a potential therapeutic target. The precise cellular origin of HCL is a late-activated postgerminal center memory B cell. BRAF mutations were detected in hematopoietic stem cells (HSCs) of patients with HCL, suggesting that this is an early HCL-defining event. Watch-and-wait strategy is necessary in approximately 10% of asymptomatic HCL patients, sometimes for several years. Purine analogs (PNAs) are the established first-line options for symptomatic HCL patients. In second-line treatment, chemoimmunotherapy combining PNA plus rituximab should be considered in high-risk HCL patients. The three options for relapsed/refractory HCL patients include recombinant immunoconjugates targeting CD22, BRAF inhibitors, and BCR inhibitors. The clinical interest to investigate blood minimal residual disease (MRD) was recently demonstrated, with a high risk of relapse in patients with positive testing for MRD and a low risk in patients with negative testing. However, efforts must be made to standardize MRD analyses in the near future. Patients with HCL are at risk of second malignancies. The increased risk could be related to the disease and/or the treatment, and the respective role of PNAs in the development of secondary malignancies remains a topic of debate.