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Tuftsin diacetate
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Tuftsin diacetate

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Tuftsin diacetate is a macrophage/microglial activator.

Category
Peptide Inhibitors
Catalog number
BAT-010647
CAS number
72103-53-8
Molecular Formula
C23H44N8O8
Molecular Weight
620.70
Tuftsin diacetate
IUPAC Name
acetic acid;(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Synonyms
L-Arginine, N2-[1-(N2-L-threonyl-L-lysyl)-L-prolyl]-, diacetate (salt); NSC 341953; H-Thr-Lys-Pro-Arg-OH.2CH3CO2H; L-threonyl-L-lysyl-L-prolyl-L-arginine acetic acid; TKPR diacetate salt
Related CAS
92169-45-4 (free base)
Purity
≥95%
Sequence
Thr-Lys-Pro-Arg.2CH3CO2H
Storage
Store at -20°C
Solubility
Soluble in DMSO
InChI
InChI= 1S/C21H40N8O6.2C2H4O2/c1-12(30)16(23)18(32)27-13(6-2-3-9-22)19(33)29-11-5-8-15(29)17(31)28-14(20(34)35)7-4-10-26-21(24)25;2*1-2(3)4/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(H4,24,25,26);2*1H3,(H,3,4)/t12-,13+,14+,15+,16+;;/m1../s1
InChI Key
YIIURIAYCWLLNZ-DZOCJTNESA-N
Canonical SMILES
CC(C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)O)N)O.CC(=O)O.CC(=O)O
1.In vivo antineoplastic activity of various biological response modifiers for tumors of the ovary and breast.
Stratton JA;Rettenmaier MA;DiSaia PJ J Clin Lab Immunol. 1983 Aug;11(4):181-7.
Fourteen pharmacologic agents reported to have biological activities which are directly or indirectly antineoplastic, were assayed for their ability to inhibit the growth of a mouse neoplasia (M5076) and a rat mammary adenocarcinoma (13762) implanted beneath the renal capsule of the host. Ascorbic acid, cimetidine hydrochloride. Corynebacterium parvum, dimethylsulfoxide, naloxone hydrochloride, indomethacin, muramyl-dipeptide, Protein A from Staphylococcus aureus, theophylline, tilorone (analog R11, 877DA), tuftsin diacetate and sodium ibuprofen were completely inactive as antineoplastic agents for these 2 tumors. In fact, theophylline and dimethylsulfoxide seemed to enhance the formation of 13762 metastases. Blue tongue virus and polyinocinic-polycytidylic acid were marginally effective antineoplastic agents for 13762. Polyinocinic-polycytidylic acid was an excellent antineoplastic agent for M5076; this agent not only prevented the growth of M5076, it was oncolytic.
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