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Urotensin II-Related Peptide (human, mouse, rat)

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Urotensin II-Related Peptide (human, mouse, rat) has a high affinity for urotensin II receptors in human and rat with Kds of 170 and 91 pM, respectively. In addition, it produced a long lasting hypotensive effect in anesthetized rats at 10 nmol/kg.

Category

Peptide Inhibitors

Catalog number

BAT-015319

CAS number

342878-90-4

Molecular Formula

C49H64N10O10S2

Molecular Weight

1017.22

Urotensin II-Related Peptide (human, mouse, rat)

Specification
Reference Reading

IUPAC Name

(2S)-2-[[(4R,7S,10S,13S,16S,19R)-10-(4-aminobutyl)-19-[[(2S)-2-aminopropanoyl]amino]-16-benzyl-7-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methylbutanoic acid

Synonyms

Urotensin IIB (human, mouse, rat); H-Ala-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH (Disulfide bridge: Cys2-Cys7); L-alanyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-L-valine (2->7)-disulfide; UIIB (human, mouse, rat); URP (human, mouse, rat); N-{[(4R,7S,10S,13S,16S,19R)-19-(L-Alanylamino)-10-(4-aminobutyl)-16-benzyl-7-(4-hydroxybenzyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-valine

Appearance

White Powder

Purity

≥95%

Density

1.4±0.1 g/cm3

Boiling Point

1424.2±65.0°C at 760 mmHg

Sequence

ACFWKYCV (Disulfide bridge: Cys2-Cys7)

Storage

Store at -20°C

Solubility

Soluble in Water

InChI

InChI=1S/C49H64N10O10S2/c1-27(2)41(49(68)69)59-48(67)40-26-71-70-25-39(57-42(61)28(3)51)47(66)55-36(21-29-11-5-4-6-12-29)44(63)56-38(23-31-24-52-34-14-8-7-13-33(31)34)46(65)53-35(15-9-10-20-50)43(62)54-37(45(64)58-40)22-30-16-18-32(60)19-17-30/h4-8,11-14,16-19,24,27-28,35-41,52,60H,9-10,15,20-23,25-26,50-51H2,1-3H3,(H,53,65)(H,54,62)(H,55,66)(H,56,63)(H,57,61)(H,58,64)(H,59,67)(H,68,69)/t28-,35-,36-,37-,38-,39-,40-,41-/m0/s1

InChI Key

WDZHTXUSYGCGPY-KOOAXUMWSA-N

Canonical SMILES

CC(C)C(C(=O)O)NC(=O)C1CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)CCCCN)CC3=CNC4=CC=CC=C43)CC5=CC=CC=C5)NC(=O)C(C)N

1. Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain

Yoshihiro Ishibashi, Masahiko Fujino, Yukio Shimomura, Nobuhiro Suzuki, Yuko Murakami, Masaaki Mori, Tsukasa Sugo, Chieko Kitada, Michiko Abe, Mioko Harada, Nobuyuki Miyajima Biochem Biophys Res Commun . 2003 Oct 24;310(3):860-8. doi: 10.1016/j.bbrc.2003.09.102.

Urotensin II (UII) has been reported as the most potent known vasoconstrictor. While rat and mouse orthologs of UII precursor protein have been reported, only the tentative structures of UII peptides of these animals have been demonstrated, since prepro-UII proteins lack typical processing sites for their mature peptides. In the present study, we isolated a novel peptide, UII-related peptide (URP), from the extract of the rat brain as the sole immunoreactive substance to anti-UII antibody; the amino acid sequence of the peptide was determined as ACFWKYCV. cDNAs encoding rat, mouse, and human precursor proteins for URP were cloned and revealed that the sequences of mouse and human URP peptides are the same as that for rat URP. Prepro-URP gene is expressed in several rat tissues such as those of the thymus, spleen, testis, and spinal cord, although with lower levels than the prepro-UII gene. In the human, the prepro-URP gene is expressed comparably to prepro-UII in several tissues except the spinal cord. URP was found to bind and activate the human or rat UII receptors (GPR14) and showed a hypotensive effect when administered to anesthetized rats. These results suggest that URP is the endogenous and functional ligand for UII receptor in the rat and mouse, and possibly in the human. We also describe the preparation of specific monoclonal antibodies raised against UII peptide and the establishment of a highly sensitive enzyme immunoassay system for UII peptides.