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Vaby A

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Vaby A is an antibacterial peptide isolated from Viola abyssinica.

Category
Functional Peptides
Catalog number
BAT-010922
Molecular Formula
C115H175N35O39S6
Molecular Weight
2864.2
IUPAC Name
3-[(1R,4S,7S,13S,19S,22S,25S,28R,31S,34S,40S,43S,46R,49S,52R,58S,64S,67S,70R,73S,82S,85R,88S,91S)-19,67-bis(2-amino-2-oxoethyl)-31-[(2S)-butan-2-yl]-22-(3-carbamimidamidopropyl)-25,64,73,88-tetrakis[(1R)-1-hydroxyethyl]-43,49-bis(hydroxymethyl)-40-(1H-indol-3-ylmethyl)-82-methyl-13-(2-methylpropyl)-3,6,12,15,18,21,24,27,30,33,39,42,45,48,51,54,57,63,66,69,72,75,78,81,84,87,90,93,96-nonacosaoxo-4-propan-2-yl-2a,3a,6a,7a,98,99-hexathia-2,5,11,14,17,20,23,26,29,32,38,41,44,47,50,53,56,62,65,68,71,74,77,80,83,86,89,92,95-nonacosazaheptacyclo[50.44.4.428,70.446,85.07,11.034,38.058,62]octahectan-91-yl]propanoic acid
Synonyms
Gly-Leu-Pro-Val-Cys-Gly-Glu-Thr-Cys-Ala-Gly-Gly-Thr-Cys-Asn-Thr-Pro-Gly-Cys-Ser-Cys-Ser-Trp-Pro-Ile-Cys-Thr-Arg-Asn
Sequence
(cyclo)-AGGTC(1)NTPGC(2)SC(3)SWPIC(1)TRNGLPVC(2)GETC(3)-(cyclo)
InChI
InChI=1S/C115H175N35O39S6/c1-12-51(6)86-108(183)139-73-48-195-194-47-72-101(176)133-63(34-78(117)158)96(171)147-90(56(11)156)114(189)150-30-16-22-74(150)104(179)126-40-82(162)130-69-44-191-190-43-68(138-107(182)85(50(4)5)143-105(180)75-23-17-28-148(75)112(187)64(31-49(2)3)129-81(161)39-124-92(167)62(33-77(116)157)132-94(169)60(21-15-27-120-115(118)119)131-110(185)88(54(9)154)146-103(73)178)93(168)125-38-80(160)128-61(25-26-84(164)165)95(170)145-89(55(10)155)111(186)140-70(99(174)127-52(7)91(166)123-36-79(159)122-37-83(163)142-87(53(8)153)109(184)141-72)45-192-193-46-71(137-98(173)67(42-152)135-100(69)175)102(177)136-66(41-151)97(172)134-65(32-57-35-121-59-20-14-13-19-58(57)59)113(188)149-29-18-24-76(149)106(181)144-86/h13-14,19-20,35,49-56,60-76,85-90,121,151-156H,12,15-18,21-34,36-48H2,1-11H3,(H2,116,157)(H2,117,158)(H,122,159)(H,123,166)(H,124,167)(H,125,168)(H,126,179)(H,127,174)(H,128,160)(H,129,161)(H,130,162)(H,131,185)(H,132,169)(H,133,176)(H,134,172)(H,135,175)(H,136,177)(H,137,173)(H,138,182)(H,139,183)(H,140,186)(H,141,184)(H,142,163)(H,143,180)(H,144,181)(H,145,170)(H,146,178)(H,147,171)(H,164,165)(H4,118,119,120)/t51-,52-,53+,54+,55+,56+,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,85-,86-,87-,88-,89-,90-/m0/s1
InChI Key
JRQOVZFYMIMYDG-KAIQXEDGSA-N
Canonical SMILES
CCC(C)C1C(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)N4CCCC4C(=O)NCC(=O)NC5CSSCC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N6CCCC6C(=O)N1)CC7=CNC8=CC=CC=C87)CO)NC(=O)C(NC5=O)CO)C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)N3)C(C)O)C)C(C)O)CCC(=O)O)NC(=O)C(NC(=O)C9CCCN9C(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC2=O)C(C)O)CCCNC(=N)N)CC(=O)N)CC(C)C)C(C)C)C(C)O)CC(=O)N
1. Photoresponsive Carbon-Azobenzene Hybrids: A Promising Material for Energy Devices
Anjana Baby, Athira Maria John, Sreeja Puthenveetil Balakrishnan Chemphyschem. 2022 Nov 29;e202200676. doi: 10.1002/cphc.202200676. Online ahead of print.
Advancements in renewable energy technology have been a hot topic in the field of photoresponsive materials for a sustainable community. Organic compounds that function as photoswitches is being researched and developed for use in a variety of energy storage systems. Azobenzene photoswitches can be used to store and release solar energy in solar thermal fuels. This review draws out the significance of azobenzene as photoswitches and its recent advances in solar thermal fuels. The recent developments of nano carbon templated azobenzene, their interactions and the effect of substituents are highlighted. The review also introduces their applications in solar thermal fuels and concludes with the challenges and future scope of the material. The advancements of solar thermal fuels with cost effective and desired optimal properties can be explored by scientists and engineers from different technological backgrounds.
2. Can technological advancements help to alleviate COVID-19 pandemic? a review
Mervin Joe Thomas, Vishnu Lal, Ajith Kurian Baby, Muhammad Rabeeh Vp, Alosh James, Arun K Raj J Biomed Inform. 2021 May;117:103787. doi: 10.1016/j.jbi.2021.103787. Epub 2021 Apr 20.
The COVID-19 pandemic is continuing, and the innovative and efficient contributions of the emerging modern technologies to the pandemic responses are too early and cannot be completely quantified at this moment. Digital technologies are not a final solution but are the tools that facilitate a quick and effective pandemic response. In accordance, mobile applications, robots and drones, social media platforms (such as search engines, Twitter, and Facebook), television, and associated technologies deployed in tackling the COVID-19 (SARS-CoV-2) outbreak are discussed adequately, emphasizing the current-state-of-art. A collective discussion on reported literature, press releases, and organizational claims are reviewed. This review addresses and highlights how these effective modern technological solutions can aid in healthcare (involving contact tracing, real-time isolation monitoring/screening, disinfection, quarantine enforcement, syndromic surveillance, and mental health), communication (involving remote assistance, information sharing, and communication support), logistics, tourism, and hospitality. The study discusses the benefits of these digital technologies in curtailing the pandemic and 'how' the different sectors adapted to these in a shorter period. Social media and television's role in ensuring global connectivity and serving as a common platform to share authentic information among the general public were summarized. The World Health Organization and Governments' role globally in-line with the prevention of propagation of false news, spreading awareness, and diminishing the severity of the COVID-19 was discussed. Furthermore, this collective review is helpful to investigators, health departments, Government organizations, and policymakers alike to facilitate a quick and effective pandemic response.
3. A short review of alternative ingredients and technologies of inorganic UV filters
Érika Minuci Nery, Renata Miliani Martinez, Maria Valéria Robles Velasco, André Rolim Baby J Cosmet Dermatol. 2021 Apr;20(4):1061-1065. doi: 10.1111/jocd.13694. Epub 2020 Sep 16.
Background: The growing need to use sunscreens is a concrete reality, and it is associated with the increase in the population's awareness of the ultraviolet (UV) radiation damage. Inorganic UV filters promote the formation of particles/pigments film over the skin surface, reflecting, dispersing, and absorbing the radiation. Investigations of this class of filters demonstrate the emergence of alternative ingredients and new technologies. Aims and methods: In this review, we presented potential candidates for alternative UV inorganic filters, such as hydroxyapatite, cerium dioxide, and hydrotalcite. Results: Specialized literature identified hydroxyapatite and cerium dioxide as actives with good performances, with a broad spectrum of absorption against UV radiation. Both of them were considered safe against degradation and skin erythema formation. Inorganic compounds as an alternative to circumvent degradation problems of organic UV filters containing PABA were also analyzed, with hydrotalcite having a good performance in improving the performance of classic ingredients, bypassing photoinstability, and improving safety, in addition to preventing skin irritability. Conclusion: Further investigations of these ingredients and interactions with sunscreen formulations are necessary to overall explore their safety and efficacy, encouraging future researches for more inorganic UV filters.
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