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VIR-165

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VIR-165 is a modified form of virus inhibitory peptide (VIRIP) that binds the fusion peptide of the gp41 subunit and prevents its insertion into the target membrane. It can inhibit a wide variety of human immunodeficiency virus type 1 (HIV-1) strains.

Category

Peptide Inhibitors

Catalog number

BAT-009384

Molecular Formula

C109H158N22O25S2

Molecular Weight

2240.6999999999998

Specification

IUPAC Name

(4S)-5-[[(2S)-1-[[(2S,3S)-1-[(2S)-2-[[(3S,9S,12S,15R,20R,23S)-20-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]-9-[(2S)-butan-2-yl]-12-(hydroxymethyl)-2,8,11,14,22-pentaoxo-17,18-dithia-1,7,10,13,21-pentazatricyclo[21.3.0.03,7]hexacosan-15-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-[[(2S)-2-amino-4-methylpentanoyl]amino]-5-oxopentanoic acid

Synonyms

Mutant of Virus-inhibitory peptide (VIRIP); NH2-Leu-Glu-Ala-Ile-Pro-Cys(x1)-Ser-Ile-Pro-Pro-Cys(x1)-Phe-Ala-Phe-Asn-Lys-Pro-Phe-Val-Phe-COOH

Sequence

LEAIPCSIPPCFAFNKPFVF

InChI

InChI=1S/C109H156N22O25S2/c1-11-62(7)88(126-91(137)65(10)113-93(139)71(44-45-86(134)135)115-92(138)70(111)51-60(3)4)107(153)130-49-29-42-83(130)103(149)124-80-59-158-157-58-79(123-102(148)82-41-28-48-129(82)106(152)84-43-30-50-131(84)108(154)89(63(8)12-2)127-98(144)78(57-132)122-100(80)146)99(145)118-73(52-66-31-17-13-18-32-66)94(140)114-64(9)90(136)117-74(53-67-33-19-14-20-34-67)95(141)119-76(56-85(112)133)96(142)116-72(39-25-26-46-110)105(151)128-47-27-40-81(128)101(147)120-75(54-68-35-21-15-22-36-68)97(143)125-87(61(5)6)104(150)121-77(109(155)156)55-69-37-23-16-24-38-69/h13-24,31-38,60-65,70-84,87-89,132H,11-12,25-30,39-59,110-111H2,1-10H3,(H2,112,133)(H,113,139)(H,114,140)(H,115,138)(H,116,142)(H,117,136)(H,118,145)(H,119,141)(H,120,147)(H,121,150)(H,122,146)(H,123,148)(H,124,149)(H,125,143)(H,126,137)(H,127,144)(H,134,135)(H,155,156)/t62-,63-,64-,65-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,87-,88-,89-/m0/s1

InChI Key

LXXYOCAOYCSKEP-AKMQUIECSA-N

Canonical SMILES

CCC(C)C1C(=O)N2CCCC2C(=O)N3CCCC3C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CO)NC(=O)C4CCCN4C(=O)C(C(C)CC)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)N)C(=O)NC(CC5=CC=CC=C5)C(=O)NC(C)C(=O)NC(CC6=CC=CC=C6)C(=O)NC(CC(=O)N)C(=O)NC(CCCCN)C(=O)N7CCCC7C(=O)NC(CC8=CC=CC=C8)C(=O)NC(C(C)C)C(=O)NC(CC9=CC=CC=C9)C(=O)O