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WRW4 TFA

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WRW4 TFA is a selective antagonist of formyl peptide receptor 2 (FPR2) signaling. WRW4 inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and blocks intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide.

Category

Peptide Inhibitors

Catalog number

BAT-016431

Molecular Formula

C63H66F3N15O8

Molecular Weight

1218.29

Specification

IUPAC Name

(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanamide;2,2,2-trifluoroacetic acid

Synonyms

H-Trp-Arg-Trp-Trp-Trp-Trp-NH2.TFA; L-tryptophyl-L-arginyl-L-tryptophyl-L-tryptophyl-L-tryptophyl-L-tryptophanamide trifluoroacetic acid; WRW4 Trifluoroacetate; WRW4 (trifluoroacetate salt)

Related CAS

878557-55-2 (free base)

Purity

≥95%

Sequence

WRWWWW-NH2.TFA

Storage

Store at -20°C

Solubility

Soluble in DMSO, Water

InChI

InChI=1S/C61H65N15O6.C2HF3O2/c62-44(24-34-29-67-45-17-6-1-12-39(34)45)56(78)72-50(22-11-23-66-61(64)65)57(79)74-53(27-37-32-70-48-20-9-4-15-42(37)48)59(81)76-54(28-38-33-71-49-21-10-5-16-43(38)49)60(82)75-52(26-36-31-69-47-19-8-3-14-41(36)47)58(80)73-51(55(63)77)25-35-30-68-46-18-7-2-13-40(35)46;3-2(4,5)1(6)7/h1-10,12-21,29-33,44,50-54,67-71H,11,22-28,62H2,(H2,63,77)(H,72,78)(H,73,80)(H,74,79)(H,75,82)(H,76,81)(H4,64,65,66);(H,6,7)/t44-,50-,51-,52-,53-,54-;/m0./s1

InChI Key

KIPTTXFGLVJUMS-HNZNYIAHSA-N

Canonical SMILES

C1=CC=C2C(=C1)C(=CN2)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)NC(CC5=CNC6=CC=CC=C65)C(=O)NC(CC7=CNC8=CC=CC=C87)C(=O)NC(CC9=CNC1=CC=CC=C19)C(=O)N)N.C(=O)(C(F)(F)F)O