Z-β-cyclohexyl-D-alanine dicyclohexylammonium salt
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Z-β-cyclohexyl-D-alanine dicyclohexylammonium salt

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Category
CBZ-Amino Acids
Catalog number
BAT-005794
CAS number
214852-64-9
Molecular Formula
C7H23NO4·C12H23N
Molecular Weight
486.52
Z-β-cyclohexyl-D-alanine dicyclohexylammonium salt
IUPAC Name
N-cyclohexylcyclohexanamine;(2R)-3-cyclohexyl-2-(phenylmethoxycarbonylamino)propanoic acid
Synonyms
Z-D-Cha-OH DCHA; Z-3-cyclohexyl-D-alanine dicyclohexylammonium salt
Purity
≥ 98% (HPLC)
Melting Point
155-161 °C
Storage
Store at 2-8°C
InChI
InChI=1S/C17H23NO4.C12H23N/c19-16(20)15(11-13-7-3-1-4-8-13)18-17(21)22-12-14-9-5-2-6-10-14;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h2,5-6,9-10,13,15H,1,3-4,7-8,11-12H2,(H,18,21)(H,19,20);11-13H,1-10H2/t15-;/m1./s1
InChI Key
IDRYYPLNVRWFOR-XFULWGLBSA-N
Canonical SMILES
C1CCC(CC1)CC(C(=O)O)NC(=O)OCC2=CC=CC=C2.C1CCC(CC1)NC2CCCCC2
1.The birth of flow-directed thermodilution catheters: how measurement of cardiac output became a routine procedure.
Berthelsen PG1. Acta Anaesthesiol Scand. 2015 Oct;59(9):1116-8. doi: 10.1111/aas.12513.
2.GABAergic Pharmacotherapy in the Treatment of Motor Disorders of the Central Nervous System.
Gazulla J1, Ruiz-Gazulla C, Tintore M. Curr Pharm Des. 2015;21(34):4989-95.
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system, and diseases that associate a deficiency in GABA might benefit from GABAergic drugs. Cerebellar Purkinje cells employ GABA as a neurotransmitter. Cortical cerebellar atrophy (CCA) shows Purkinje cell loss, and ataxia caused by it was alleviated by gabapentin and pregabalin. Thus, CCA is proposed as a model of selective deficiency in GABA in the cerebellum, which benefits clinically from administration of GABAergic drugs, in a manner similar in which levodopa improves motor manifestations in Parkinson's disease. Other ataxias also benefited clinically from GABAergic drugs, as adult-onset GM2 gangliosidosis, olivopontocerebellar atrophy, cerebellar ataxia with hypogonadism, spinocerebellar ataxias 1, 2 and 6, and adult-onset ataxia-telangiectasia. Complex neurochemical diseases, as multiple-system atrophy, had ataxia worsened by GABAergic drugs.
3.NO is involved in spermidine-induced drought tolerance in white clover via activation of antioxidant enzymes and genes.
Peng D1, Wang X, Li Z, Zhang Y, Peng Y, Li Y, He X, Zhang X, Ma X, Huang L, Yan Y. Protoplasma. 2015 Sep 4. [Epub ahead of print]
Nitric oxide (NO), a key signaling molecule, can be induced by polyamines (PAs), which play an important role in improving drought tolerance in plants. This study was to further investigate the role of NO in spermidine (Spd)-induced drought tolerance associated with antioxidant defense in leaves of white clover (Trifolium repens) under drought stress induced by -0.3 MPa polyethylene glycol (PEG-6000) solution. A hydroponic growth method was used for cultivating plants in a controlled growth chamber for 30-33 days until the second leaves were fully expanded. Two relative independent experiments were carried out in our study. One is that exogenous application of Spd or an NO donor (sodium nitroprusside (SNP)) significantly improved drought tolerance in whole plants, as demonstrated by better phenotypic appearance, increased relative water content (RWC), and decreased electrolyte leakage (EL) and malondialdehyde (MDA) content in leaves as compared to untreated plants.
4.Bovine lactoferrin regulates cell survival, apoptosis and inflammation in intestinal epithelial cells and preterm pig intestine.
Nguyen DN1, Jiang P2, Stensballe A3, Bendixen E4, Sangild PT2, Chatterton DE5. J Proteomics. 2016 Apr 29;139:95-102. doi: 10.1016/j.jprot.2016.03.020. Epub 2016 Mar 17.
Bovine lactoferrin (bLF) may modulate neonatal intestinal inflammation. Previous studies in intestinal epithelial cells (IECs) indicated that moderate bLF doses enhance proliferation whereas high doses trigger inflammation. To further elucidate cellular mechanisms, we profiled the porcine IEC proteome after stimulation with bLF at 0, 0.1, 1 and 10g/L by LC-MS-based proteomics. Key pathways were analyzed in the intestine of formula-fed preterm pigs with and without supplementation of 10g/L bLF. Levels of 123 IEC proteins were altered by bLF. Low bLF doses (0.1-1g/L) up-regulated 11 proteins associated with glycolysis, energy metabolism and protein synthesis, indicating support of cell survival. In contrast, a high bLF dose (10g/L) up-regulated three apoptosis-inducing proteins, down-regulated five anti-apoptotic and proliferation-inducing proteins and 15 proteins related to energy and amino acid metabolism, and altered three proteins enhancing the hypoxia inducible factor-1 (HIF-1) pathway.
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