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Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone is a cell permeable inhibitor of caspase-8 and granzyme B. The bis-methyl ester of Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone blocks CD95-induced apoptosis.

Category

Functional Peptides

Catalog number

BAT-014472

CAS number

1926163-59-8

Molecular Formula

C30H43FN4O11

Molecular Weight

654.69

Specification

IUPAC Name

methyl (4S)-5-[[(2S,3R)-1-[(5-fluoro-1-methoxy-1,4-dioxopentan-3-yl)amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[[(2S,3S)-3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoate

Synonyms

Z-IETD-FMK; Z-IE(OMe)TD(OMe)-FMK; Methyl (5S,8S,11S)-5-[(2S)-2-butanyl]-14-(fluoroacetyl)-11-[(1R)-1-hydroxyethyl]-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate

Appearance

White Powder

Purity

≥95%

Density

1.2±0.1 g/cm3

Boiling Point

925.7±65.0°C at 760 mmHg

Sequence

Cbz-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-CH2F

Storage

Store at -20°C

Solubility

Soluble in Dichloromethane

InChI

InChI=1S/C30H43FN4O11/c1-6-17(2)25(35-30(43)46-16-19-10-8-7-9-11-19)28(41)32-20(12-13-23(38)44-4)27(40)34-26(18(3)36)29(42)33-21(22(37)15-31)14-24(39)45-5/h7-11,17-18,20-21,25-26,36H,6,12-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,40)(H,35,43)/t17-,18+,20-,21?,25-,26-/m0/s1

InChI Key

PHLCQASLWHYEMX-KQURNKOZSA-N

Canonical SMILES

CCC(C)C(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)O)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1