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Z-Val-Asp(OMe)-Val-Ala-DL-Asp(OMe)-fluoromethylketone

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Z-Val-Asp(OMe)-Val-Ala-DL-Asp(OMe)-fluoromethylketone is a cell-permeable fluoromethylketone that specifically inhibits caspase-2 and, to a lesser extent, caspase-3 and caspase-7.

Category

Functional Peptides

Catalog number

BAT-014518

CAS number

1926163-61-2

Molecular Formula

C32H46FN5O11

Molecular Weight

695.73

Specification

IUPAC Name

methyl 5-fluoro-3-[[(2S)-2-[[(2S)-2-[[(2S)-4-methoxy-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-4-oxobutanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-oxopentanoate

Synonyms

Z-VD(OMe)VAD(OMe)-FMK; Z-VDVA-(DL-Asp)-FMK; Methyl (5S,8S,11S,14S)-17-(fluoroacetyl)-5,11-diisopropyl-8-(2-methoxy-2-oxoethyl)-14-methyl-3,6,9,12,15-pentaoxo-1-phenyl-2-oxa-4,7,10,13,16-pentaazanonadecan-19-oate

Appearance

White Lyophilized Powder

Purity

≥90%

Density

1.2±0.1 g/cm3

Boiling Point

980.1±65.0°C at 760 mmHg

Sequence

Cbz-Val-Asp(OMe)-Val-Ala-DL-Asp(OMe)-FMK

Storage

Store at -20°C

Solubility

Soluble in Acetic Acid

InChI

InChI=1S/C32H46FN5O11/c1-17(2)26(30(44)34-19(5)28(42)35-21(23(39)15-33)13-24(40)47-6)37-29(43)22(14-25(41)48-7)36-31(45)27(18(3)4)38-32(46)49-16-20-11-9-8-10-12-20/h8-12,17-19,21-22,26-27H,13-16H2,1-7H3,(H,34,44)(H,35,42)(H,36,45)(H,37,43)(H,38,46)/t19-,21?,22-,26-,27-/m0/s1

InChI Key

ANTIWMNLIROOQF-CNKNRCHBSA-N

Canonical SMILES

CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC(=O)OC)NC(=O)C(C(C)C)NC(=O)OCC1=CC=CC=C1