Other Unnatural Amino Acids

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Other Unnatural Amino Acids

N-(2-Amino-ethyl)-2-(benzyl-phenyl-amino)-acetamide maleate

CAS 1185241-40-0
Catalog BAT-015091
Molecular Weight 399.44
Molecular Formula C21H25N3O5
N-(2-Amino-ethyl)-2-(benzyl-phenyl-amino)-acetamide maleate

Biotin-PEG2-NH2

CAS 138529-46-1
Catalog BAT-015379
Molecular Weight 374.50
Molecular Formula C16H30N4O4S
Biotin-PEG2-NH2

H-Phe-AMC

CAS 98516-72-4
Catalog BAT-015482
Molecular Weight 322.36
Molecular Formula C19H18N2O3
H-Phe-AMC

H-Pro-AMC

CAS 96643-94-6
Catalog BAT-015501
Molecular Weight 272.30
Molecular Formula C15H16N2O3
H-Pro-AMC

H-Lys-AMC

CAS 92605-76-0
Catalog BAT-015545
Molecular Weight 303.36
Molecular Formula C16H21N3O3
H-Lys-AMC

H-Ser-AMC

CAS 98516-73-5
Catalog BAT-015546
Molecular Weight 262.27
Molecular Formula C13H14N2O4
H-Ser-AMC

H-Arg(NO2)-Obzl

CAS 7672-27-7
Catalog BAT-015672
Molecular Weight 309.32
Molecular Formula C13H19N5O4
H-Arg(NO2)-Obzl

H-His-OEt · 2 HCl

CAS 93923-84-3
Catalog BAT-015673
Molecular Weight 256.13
Molecular Formula C8H15Cl2N3O2
H-His-OEt · 2 HCl

Glycine, phenylmethylester

CAS 1738-68-7
Catalog BAT-015746
Molecular Weight 165.19
Molecular Formula C9H11NO2
Glycine, phenylmethylester

H-Asn-AMC

CAS 115047-89-7
Catalog BAT-015790
Molecular Weight 289.29
Molecular Formula C14H15N3O4
H-Asn-AMC

Pam3-Cys-OH

CAS 87420-41-5
Catalog BAT-015835
Molecular Weight 910.46
Molecular Formula C54H103NO7S
Pam3-Cys-OH

S-MTC

CAS 156719-41-4
Catalog BAT-015935
Molecular Weight 205.28
Molecular Formula C7H15N3O2S
Sequence H-ThioCit(S-Me)-OH
S-MTC

Carbamoyl-Asp-OH · magnesium salt/Carbamoyl-Asp-OH · dipotassium salt (1:1)

CAS 13184-27-5
Catalog BAT-015987
Molecular Weight 450.73
Molecular Formula C10H12K2MgN4O10
Carbamoyl-Asp-OH · magnesium salt/Carbamoyl-Asp-OH · dipotassium salt (1:1)

5-Aminolevulinic acid phosphate

CAS 868074-65-1
Catalog BAT-015994
Molecular Weight 229.12
Molecular Formula C5H12NO7P
5-Aminolevulinic acid phosphate

2,2'-((2-((Carboxymethyl)(2-((carboxymethyl)amino)ethyl)amino)ethyl)azanediyl)diacetic acid

CAS 128139-51-5
Catalog BAT-015995
Molecular Weight 335.31
Molecular Formula C12H21N3O8
2,2'-((2-((Carboxymethyl)(2-((carboxymethyl)amino)ethyl)amino)ethyl)azanediyl)diacetic acid

Diethylenetriaminetetraacetic acid

CAS 13811-41-1
Catalog BAT-015996
Molecular Weight 335.31
Molecular Formula C12H21N3O8
Diethylenetriaminetetraacetic acid

Ethylenediaminetriacetic acid

CAS 688-57-3
Catalog BAT-015997
Molecular Weight 234.21
Molecular Formula C8H14N2O6
Ethylenediaminetriacetic acid

DA-67

CAS 115871-18-6
Catalog BAT-015999
Molecular Weight 408.45
Molecular Formula C19H21N4NaO3S
DA-67

Sarcosine ethyl ester

CAS 13200-60-7
Catalog BAT-016004
Molecular Weight 117.14
Molecular Formula C5H11NO2
Sarcosine ethyl ester

Aminolevulinic Acid

CAS 106-60-5
Catalog BAT-016012
Molecular Weight 131.13
Molecular Formula C5H9NO3
Aminolevulinic Acid

Overview

Unnatural amino acids are amino acids that are not encoded by any of the 64 existing genetic codons. The site-specificity, low perturbation of protein structure, high sensitivity and flexibility of use of non-natural amino acid systems have led to their application in basic research and drug discovery, bioengineering and other fields. Unnatural amino acids are also widely used to detect changes in protein structure, drug conjugation, and biosensors.

Variety

A range of non-natural amino acids have been used for protein modification in bacteria, yeast and mammalian cells with great precision and efficiency; most of them are derivatives of 20 natural amino acids, and the unnatural amino acids derivatives reported today are phenylalanine derivatives, tyrosine derivatives, glutamine derivatives, alanine derivatives, leucine derivatives, serine derivatives, lysine derivatives, etc.

Applications

Non-natural amino acids are major components of synthetic peptides and peptide-like drugs, both domestically and internationally, and have a significant role in biochemistry, medicine, and the food sector, etc.

1. Applications in Biocatalysis

By introducing unnatural structural components such as unnatural amino acids into proteins, artificial enzymes with high catalytic activity or completely new reactivity can be obtained, with the expectation of achieving unnatural chemical reactions that are comparable to the catalytic efficiency of natural enzymes and extending the application of biocatalysis in organic synthesis. In addition, non-natural amino acid technology has been successfully applied to the establishment of a light-energy fixed CO2 enzyme, enabling artificial photosynthesis.

2. Applications in Pharmacy

Many of the drugs currently on the market contain structures of unnatural amino acids. The most important angiotensin-converting enzyme (ACE) inhibitors for the treatment of hypertension mostly contain side chain structures of unnatural amino acids. l-norvaline is the main intermediate in the synthesis of perindopril, a third-generation angiotensin-converting enzyme inhibitor. Antitumour and antiviral drugs synthesized from non-natural amino acids are less toxic and more selective in humans, and many varieties have shown good efficacy and promise. For example, leucine derivatives are key side chains in the synthesis of the antiviral drug atazanavir, an antiretroviral drug used to treat human immunodeficiency virus (HIV) infection. D-Alanine has been used extensively in the synthesis of intermediates for Alzheimer's drugs. Peptide analgesics consisting of unnatural amino acids do not have the gastrointestinal side effects of clinically used analgesics and are long-lasting and effective. For example, hyoscine, which is synthesized using a phenylalanine derivative, is now in clinical use.

3. Applications in Food Industry

In addition, unnatural amino acids have a role in the food sector, as dipeptides or short peptides (aspartame) made up of D-amino acids are sweet, safe, non-caloric and suitable for consumption by the general population as well as by obese and diabetic patients.

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