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BOC Sciences provides feature articles on innovative products or services for research on peptides, amino acids, PNA monomers, and peptide synthetic resins.
Peptides are compounds formed when alpha amino acids are linked together by peptide bonds. The application scenarios cover new hotspots and valuable research fields, such as disease-related research, cosmetic peptides, and protein modification.
Peptides can be used in many diseases and have very good curative effects.
Diabetes mellitus is a metabolic disease caused by multiple etiologies and is characterized by chronic hyperglycemia. Peptides can activate and repair islet cells, promote islet cells to synthesize insulin, and regulate blood sugar in both directions.
Cancer (malignant tumor) destroys the structure and function of tissues and organs and has become one of the most common fatal diseases. Peptides can inhibit the growth and metastasis of cancer cells, kill cancer cells, remove toxins in cancer cells, and have the effect of preventing, controlling and adjuvant therapy of tumors.
Cardiovascular disease is a general term for cardiovascular and peripheral vascular diseases, including heart failure, coronary heart disease, arrhythmia, hypertension, etc. Peptides can remove intravascular lipids, regulate heart function, restore cardiovascular functions, and have certain curative effects on cardiovascular diseases.
The immune system is an important system for the body to carry out immune response and immune function. It can find and remove foreign bodies, foreign pathogenic microorganisms and other factors that cause fluctuations in the internal environment. Peptides can play a role in regulating immunity, antibacterial, and nutritional supplements.
Human Immunodeficiency Virus (HIV) is a virus that causes a deficiency in the body's immune system. HIV destroys the body's T lymphocytes, thereby blocking the process of cellular immunity and humoral immunity, leading to paralysis of the immune system, and eventually leading to acquired immunodeficiency syndrome (AIDS). Antiretroviral therapy minimizes HIV replication.
Human papilloma virus (HPV) is a papilloma virus that uses humans as its sole host. HPV has a high degree of tissue specificity and can infect human epidermal and mucosal epithelial cells, and can cause a variety of benign and malignant tumors. E6/E7 refers to two gene fragments of HPV, and the expression of its protein is a necessary factor for cell carcinogenesis.
Alzheimer's disease is a progressive central neurodegenerative disease of unknown etiology. Alzheimer's disease mostly occurs in old age or pre-senile age, and develops slowly and irreversibly. Clinically, it is mainly manifested as generalized dementia such as abnormal memory, cognition, thinking and behavior. Research is now focused on reducing beta-amyloid peptides, the causative agent of Alzheimer's disease.
Osteoporosis is a systemic multi-causal skeletal disease that is prone to fractures due to changes in systemic bone mass and microstructure of bone tissue, resulting in increased bone fragility. At present, the clinical anti-osteoporosis drugs are mainly divided into two categories. One is a drug that inhibits bone resorption, and the other is a drug that promotes bone formation.
Gastrointestinal peptide hormones are widely distributed in the gastrointestinal mucosa and inner nervous system, and have important regulatory effects on gastrointestinal smooth muscle movement, mucosal gland secretion, blood supply, local inflammatory cells, immune active cells and cytokines.
Cosmetic peptides have the advantages of safety, stability, easy absorption and good effect. Adding them to cosmetics can fundamentally improve and repair various skin problems.
Peptides are widely used in cosmetics, providing a new direction and idea for the research and development and application of cosmetics. The main cosmetic effects of peptides used in cosmetics are to promote cell metabolism, activate cell activity, inhibit cell degeneration, repair damaged cells, promote collagen synthesis and promote cell healing.
Peptide modification is mainly the modification of the main chain structure and side chain groups of the peptide chain. Modifications can alter the physicochemical properties of peptides to optimize their effective utilization in vivo.
Cyclization is the most direct way to synthesize cyclic peptides, especially for peptides with larger structural backbones. According to the cyclization method of cyclic peptides, it can be divided into side chain -to-side chain type, head-to-tail type, side chain-to-end type, and disulfide-bridge, etc.
The phosphorylation modification of peptides mainly refers to the conversion of the side chain hydroxyl groups of serine (Ser), threonine (Thr) or tyrosine (Tyr) residues in the peptide chain into the form of phosphate. Phosphorylated tyrosine, phosphorylated threonine, and phosphorylated serine derivatives can either be introduced into the polypeptide during synthesis or formed after polypeptide synthesis.
