Peptides for Immunity and Infection Research

Introduction to Anti-Infection and Immunity Research

Humans and pathogenic microorganisms have always been in a dynamic balance of interdependence, struggle and mutual influence. The body's own natural barrier and immune function are important ways to defend and resist the invasion of pathogenic microorganisms. The body's own natural barriers include the barrier function of the skin and mucous membranes, the presence of normal flora, the blood-brain barrier, and the placental barrier. Once pathogenic microorganisms pass through the body's natural barrier and enter the blood vessels or the normal environment of the body, they must face the body's strong and well-established immune response. The immune response of the body includes cellular immune response and humoral immune response. The cellular immune response includes cellular immunity mediated by T lymphocytes, macrophages and natural killer cells. The cellular immune response plays an irreplaceable role in the prevention and clearance of most viral, bacterial, fungal, and parasitic infections.

White blood cell attack virus - BOC Sciences

The body's anti-infection defense mechanism includes two kinds of non-specific immune response and specific immune response.

Natural non-specific body defense mechanism, also known as innate immunity. It refers to the rapid response mechanism that exists after birth and does not need to be stimulated by foreign or potential pathological antigens to resist infection by pathogenic microorganisms. It includes physical and chemical barriers, phagocytes, humoral proteins, cytokines. The non-specific immune response confines pathogenic microorganisms to local parts of the body, allowing the body time to establish a specific immune response. The non-specific body defense mechanism is the first line of defense of the body defense mechanism.

Specific body defense mechanism, also known as acquired immunity. The main immune effector cells include B lymphocytes, T lymphocytes, plasma cells, macrophages, and dendritic cells. After pathogenic microorganisms invade the body, a specific immune response is initiated.

Peptides & Immunity and Infection Research

The immune system is an important system for the body to perform immune response and immune function. It is composed of immune organs, immune cells and immune active substances. It is the most effective weapon against pathogen invasion. The immune system can find and remove foreign bodies, foreign pathogenic microorganisms and other factors that cause fluctuations in the internal environment.

There has been some corresponding research on the effect of peptides on the immune system.

Peptides have immunomodulatory functions. Certain peptides, such as thymopentin, can intervene in certain autoimmune diseases and various diseases with low cellular immunity.

Peptides have antimicrobial properties. Antimicrobial peptides and other small molecular peptides can activate and regulate the immune response of the body, and significantly promote the proliferation of human peripheral blood lymphocytes, thereby playing an anti-microbial effect.

Peptides can supplement nutrition. As nutritional supplements, small molecule peptides can quickly supplement the nutrients needed by the body. In addition, peptides can also deliver various other nutrients.

Treatment of infectious diseases - BOC Sciences

  • Thymopentin & Analogs

Thymopentin is an effective part of a thymopoietin secreted by the thymus gland, consisting of five amino acids: arginine, lysine, aspartic acid, valine, and tyrosine. Thymopentin can enhance the body's immunity and improve the body's anti-infection ability through a variety of ways. Thymopentin has a regulatory effect on the immune function of immunocompromised animals and patients with autoimmune diseases, and can normalize excessive or suppressed immune responses. Thymopentin is suitable for the treatment of certain autoimmune diseases and various diseases with low cellular immune function, and can also be used for adjuvant therapy of tumors.

NameCASSequencePrice
Thymopentin Acetate177966-81-3H-Arg-Lys-Asp-Val-Tyr-OH.CH3CO2HInquiry
Thymopentin69558-55-0Arg-Lys-Asp-Val-TyrInquiry
  • Melittin & Related Peptides

Melittin is the main component and main biologically active substance of bee venom. It is a peptide composed of 26 amino acid residues. Mellitin has strong anti-inflammatory and antibacterial effects, and can effectively treat collagen diseases and immune system diseases.

NameCASSequencePrice
Melittin20449-79-0GIGAVLKVLTTGLPALISWIKRKRQQ-NH2Inquiry
Antibacterial peptide/melittin homologFALALKALKKALKKLKKALKKALInquiry
Melittin-like peptideFIGSALKVLAGVLPSIVSWVKQInquiry
AR-23AIGSILGALAKGLPTLISWIKNRInquiry
  • OVA Peptides

Ovalbumin (OVA) is an important reference protein for immunological and biochemical research. OVA is the main protein component in egg white, which can cause moderate immunity of the body. OVA peptide is a peptide substance obtained by enzymatic engineering using ovalbumin as a raw material, which can be used to stimulate the activation of T cells and has an immune-enhancing effect on the body.

NameCASSequencePrice
OVA Peptide 323-33992915-79-2ISQAVHAAHAEINEAGRInquiry
OVA Peptide 257-264138831-86-4SIINFEKLInquiry
OVA G4 peptide148274-82-2SIIGFEKLInquiry
OVA sequence 323-33692915-80-5ISQAVHAAHAEINEInquiry
OVA Peptide (257-264) TFA1262751-08-5SIINFEKL.TFAInquiry
OVA (241-270)SMLVLLPDEVSGLEQLESIINFEKLTEWTSInquiry
  • Antimicrobial Peptides (AMP)

Antimicrobial peptides are small molecular polypeptides with biological activity induced in vivo. As an important part of the body's natural immunity, antimicrobial peptides have the advantages of cationicity, small molecular weight, broad antibacterial spectrum, and good thermal stability. Studies have shown that antimicrobial peptides have antibacterial activity as well as a wide range of immunomodulatory functions. Certain antimicrobial peptides can kill some viruses, fungi, protozoa and cancer cells, and even improve immunity and accelerate wound healing.

View Our List of Antimicrobial Peptides >

  • Protease Activated Receptor (PAR) Peptide & Analogs

Protease-activated receptors (PARs) are members of the G protein-coupled receptor family involved in regulating cellular functions and mediating transmembrane signaling. Studies have found that activated PARs play an important role in the occurrence and development of inflammation and immune responses.

NameCASSequencePrice
PAR4 (1-6) (human)225779-44-2GYPGQVInquiry
Protease-Activated Receptor-4245443-52-1GYPGKF-NH2Inquiry
Parstatin (mouse)1065756-01-5MGPRRLLIVALGLSLCGPLLSSRVPMSQPESERTDATVNPRInquiry
AY-NH2352017-71-1Ala-Tyr-Pro-Gly-Lys-Phe-NH2Inquiry
PAR-4 Agonist Peptide, amide TFA1228078-65-6Ala-Tyr-Pro-Gly-Lys-Phe-NH2Inquiry
TRAP-6 (2-6)141136-84-7H-Phe-Leu-Leu-Arg-Asn-OHInquiry
  • Apolipoprotein & Apolipoprotein Mimetic Peptide

Apolipoprotein is an important plasma lipoprotein. Apolipoproteins can exert anti-inflammatory and immunomodulatory effects through the regulation of cytokine expression. Apolipoprotein mimetic peptides have similar anti-inflammatory effects as apolipoproteins in immunotherapy.

NameCASSequencePrice
COG 133514200-66-9LRVRLASHLRKLRKRLLInquiry
COG-1410878009-24-6ASXLRKLXKRLLInquiry
  • Protein Substrates

Most protease assays used in immunological and biochemical research employ peptides as substrates for proteases. Peptides are small fragments of proteins. Peptides as protein substrates are designed according to the sequence near the enzyme cleavage site, which guarantees a certain specificity.

  • Protein Kinase Substrates
NameCASSequencePrice
Crebtide149155-45-3KRREILSRRPSYRInquiry
Kemptide65189-71-1LRRASLGInquiry
Kemptide Phospho-Ser5LRRA-pSer-LGInquiry
PKG Substrate81187-14-6RKRSRAEInquiry
Malantide86555-35-3RTKRSGSVYEPLKIInquiry
DAPK Substrate Peptide386769-53-5KKRPQRRYSNVFInquiry
SAMS125911-68-4HMRSAMSGLHLVKRRInquiry
AMARA peptide TFAAMARAASAAALARRR.TFAInquiry
  • Dipeptidyl Aminopeptidase I (Cathepsin C) Substrates
NameCASSequencePrice
PAβN dihydrochloride100929-99-5H-Phe-Arg-NA.2HClInquiry
Gly-Phe-pNA HClGly-PheInquiry
Ala-Ala-OMe HCl41036-19-5Inquiry
Gly-Phe-pNA21027-72-5Inquiry
  • Other Aminopeptidase Substrates
NameCASCatalog No.Price
Gly-Gly-Gly-OH556-33-2BAT-005011Inquiry
Gly-Leu-OH869-19-2BAT-005023Inquiry
Gly-Pro-pNA TosOH65096-46-0BAT-005031Inquiry
Pro-Gly-Gly-OH7561-25-3BAT-006535Inquiry
Lys-Ala-βNA20314-31-2BAT-006523Inquiry
  • Chymotrypsin Substrates
NameCASSequencePrice
RETF-4NA1160928-63-1Ac-DL-Arg-DL-Glu-DL-xiThr-DL-Phe-pNAInquiry
Ala-Ala-Phe-pNA61043-41-2Inquiry
Suc-Ala-Ala-Pro-Phe-AMC88467-45-2Inquiry
  • Caspase Substrates
NameCASSequencePrice
Ac-WEHD-AFC210344-99-3Ac-Trp-Glu-His-Asp-UnkInquiry
Z-LLE-AMC348086-66-8Cbz-Leu-Leu-Glu-AMCInquiry
Ac-DEVD-AFC201608-14-2N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoroMethylcoumarinInquiry
  • Elastase Substrates
NameCASSequencePrice
MeoSuc-Ala-Ala-Pro-Val-AMC72252-90-5MeOSuc-Ala-Ala-Pro-Val-AMCInquiry
Suc-Ala-Ala-Ala-pNA52299-14-6Inquiry
Suc-Ala-Ala-Pro-Ala-pNA72682-69-0Inquiry
  • Thrombin Substrates
NameCASSequencePrice
Z-Gly-Gly-Arg-AMC acetate2070009-61-7Z-Gly-Gly-Arg-AMCInquiry
Z-Gly-Gly-Arg-AMC66216-78-2Z-Gly-Gly-Arg-AMCInquiry
  • Prolinase Substrates
NameCASSequencePrice
H-Gly-Pro-OH704-15-4Gly-ProInquiry
L-Prolyl-L-alanine6422-36-2Inquiry
Pro-Gly-OH2578-57-6Inquiry
Val-Pro-OH HCl105931-64-4Inquiry
Z-Gly-Pro-pNA65022-15-3Inquiry
  • Carboxypeptidase Substrates
NameCASCatalog No.Price
Z-Ala-Phe-OH2768-53-8BAT-006563Inquiry
Z-Gly-Phe-OH1170-76-9BAT-006575Inquiry
Z-Leu-Phe-OH6401-63-4BAT-006583Inquiry
Z-Phe-Gly-OH13122-99-1BAT-006589Inquiry
Z-Phe-Leu-OH4313-73-9BAT-006590Inquiry
  • Cathepsin A Substrates
NameCASCatalog No.Price
Z-Phe-Phe-OH13122-91-3BAT-006592Inquiry
Z-Phe-Ala-OH21881-18-5BAT-006587Inquiry
  • Other Protein Substrates
NameCASSequencePrice
Axltide143364-95-8KKSRGDYMTMQIGInquiry
Dnp-PLGMWSR135662-07-6PLGMWSRInquiry
M-2420310427-95-3Methoxycoumarin-SEVNLDAEFK-dinitrophenylInquiry
[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor 1142-1153141171-54-2TRDI-pTyr-ETD-pTyr-pTyr-RKInquiry
Z-Arg-Leu-Arg-Gly-Gly-AMC167698-69-3Cbz-Arg-Leu-Arg-Gly-Gly-AMCInquiry
Ac-Phe-Arg-Oet AcOHPhe-ArgInquiry
Suc-Ala-Glu-Pro-Phe-pNA128802-76-6AEPFInquiry
Z-Val-Gly-Arg-pNA86170-43-6Cbz-Val-Gly-Arg-pNA.CH3CO2HInquiry
Abz-FR-K(Dnp)-P-OH500799-61-1Abz-Phe-Arg-Lys(Dnp)-ProInquiry
N-p-Tosyl-Gly-Pro-Lys p-nitroanilide acetate salt88793-79-7Tos-Gly-Pro-Lys-pNA.CH3CO2HInquiry
Suc-Leu-Tyr-AMC94367-20-1Suc-Leu-Tyr-AMCInquiry
Ac-Phe-3,5-diI-Tyr-OH3786-08-1Inquiry
Boc-Glu(OBzl)-Gly-Arg-AMC HCl133448-22-3Inquiry
Cyclo(L-Trp-L-Trp)20829-55-4Inquiry
L-Arg-Pro-pNA112898-06-3Inquiry
Z-Gly-Phe-NH25513-69-9Inquiry
Z-Phe-Arg-AMC HCl65147-22-0CBZ-Phe-Arg-AMC.HClInquiry
  • Other Related Products
NameCASSequencePrice
Rabies Virus GlycoproteinYTIWMPENPRPGTPCDIFTNSRGKRASNGInquiry
Baculoviral IAP repeat-containing protein 7 (280-289)QLCPICRAPVInquiry
Glutathione70-18-8H-gGlu-Cys-Gly-OHInquiry
Pam3CSK4112208-00-1palmitoyl-Cys(Unk)-Ser-Lys-Lys-Lys-Lys-OHInquiry
Thymosin α1 Acetate62304-98-7Ac-SDAAVDTSSEITTKDLKEKKEVVEEAENInquiry
PAC-113AKRHHGYKRKFHInquiry
Daptomycin103060-53-3WNDTGKDADGSEYInquiry
Cecropin B80451-05-4KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKALInquiry
hLF1-11GRRRRSVQWCAInquiry
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