Peptides for Immunity and Infection Research

Introduction to Anti-Infection and Immunity Research

Humans and pathogenic microorganisms have always been in a dynamic balance of interdependence, struggle and mutual influence. The body's own natural barrier and immune function are important ways to defend and resist the invasion of pathogenic microorganisms. The body's own natural barriers include the barrier function of the skin and mucous membranes, the presence of normal flora, the blood-brain barrier, and the placental barrier. Once pathogenic microorganisms pass through the body's natural barrier and enter the blood vessels or the normal environment of the body, they must face the body's strong and well-established immune response. The immune response of the body includes cellular immune response and humoral immune response. The cellular immune response includes cellular immunity mediated by T lymphocytes, macrophages and natural killer cells. The cellular immune response plays an irreplaceable role in the prevention and clearance of most viral, bacterial, fungal, and parasitic infections.

The body's anti-infection defense mechanism includes two kinds of non-specific immune response and specific immune response.

Natural non-specific body defense mechanism, also known as innate immunity. It refers to the rapid response mechanism that exists after birth and does not need to be stimulated by foreign or potential pathological antigens to resist infection by pathogenic microorganisms. It includes physical and chemical barriers, phagocytes, humoral proteins, cytokines. The non-specific immune response confines pathogenic microorganisms to local parts of the body, allowing the body time to establish a specific immune response. The non-specific body defense mechanism is the first line of defense of the body defense mechanism.

Specific body defense mechanism, also known as acquired immunity. The main immune effector cells include B lymphocytes, T lymphocytes, plasma cells, macrophages, and dendritic cells. After pathogenic microorganisms invade the body, a specific immune response is initiated.

Peptides & Immunity and Infection Research

The immune system is an important system for the body to perform immune response and immune function. It is composed of immune organs, immune cells and immune active substances. It is the most effective weapon against pathogen invasion. The immune system can find and remove foreign bodies, foreign pathogenic microorganisms and other factors that cause fluctuations in the internal environment.

There has been some corresponding research on the effect of peptides on the immune system.

Peptides have immunomodulatory functions. Certain peptides, such as thymopentin, can intervene in certain autoimmune diseases and various diseases with low cellular immunity.

Peptides have antimicrobial properties. Antimicrobial peptides and other small molecular peptides can activate and regulate the immune response of the body, and significantly promote the proliferation of human peripheral blood lymphocytes, thereby playing an anti-microbial effect.

Peptides can supplement nutrition. As nutritional supplements, small molecule peptides can quickly supplement the nutrients needed by the body. In addition, peptides can also deliver various other nutrients.

• Thymopentin & Analogs

Thymopentin is an effective part of a thymopoietin secreted by the thymus gland, consisting of five amino acids: arginine, lysine, aspartic acid, valine, and tyrosine. Thymopentin can enhance the body's immunity and improve the body's anti-infection ability through a variety of ways. Thymopentin has a regulatory effect on the immune function of immunocompromised animals and patients with autoimmune diseases, and can normalize excessive or suppressed immune responses. Thymopentin is suitable for the treatment of certain autoimmune diseases and various diseases with low cellular immune function, and can also be used for adjuvant therapy of tumors.

• Melittin & Related Peptides

Melittin is the main component and main biologically active substance of bee venom. It is a peptide composed of 26 amino acid residues. Mellitin has strong anti-inflammatory and antibacterial effects, and can effectively treat collagen diseases and immune system diseases.

• OVA Peptides

Ovalbumin (OVA) is an important reference protein for immunological and biochemical research. OVA is the main protein component in egg white, which can cause moderate immunity of the body. OVA peptide is a peptide substance obtained by enzymatic engineering using ovalbumin as a raw material, which can be used to stimulate the activation of T cells and has an immune-enhancing effect on the body.

• Antimicrobial Peptides (AMP)

Antimicrobial peptides are small molecular polypeptides with biological activity induced in vivo. As an important part of the body's natural immunity, antimicrobial peptides have the advantages of cationicity, small molecular weight, broad antibacterial spectrum, and good thermal stability. Studies have shown that antimicrobial peptides have antibacterial activity as well as a wide range of immunomodulatory functions. Certain antimicrobial peptides can kill some viruses, fungi, protozoa and cancer cells, and even improve immunity and accelerate wound healing.

View Our List of Antimicrobial Peptides >

• Protease Activated Receptor (PAR) Peptide & Analogs

Protease-activated receptors (PARs) are members of the G protein-coupled receptor family involved in regulating cellular functions and mediating transmembrane signaling. Studies have found that activated PARs play an important role in the occurrence and development of inflammation and immune responses.

• Apolipoprotein & Apolipoprotein Mimetic Peptide

Apolipoprotein is an important plasma lipoprotein. Apolipoproteins can exert anti-inflammatory and immunomodulatory effects through the regulation of cytokine expression. Apolipoprotein mimetic peptides have similar anti-inflammatory effects as apolipoproteins in immunotherapy.

• Protein Substrates

Most protease assays used in immunological and biochemical research employ peptides as substrates for proteases. Peptides are small fragments of proteins. Peptides as protein substrates are designed according to the sequence near the enzyme cleavage site, which guarantees a certain specificity.

• Protein Kinase Substrates

• Dipeptidyl Aminopeptidase I (Cathepsin C) Substrates

• Other Aminopeptidase Substrates

• Chymotrypsin Substrates

• Caspase Substrates

• Elastase Substrates

• Thrombin Substrates

• Prolinase Substrates

• Carboxypeptidase Substrates

• Cathepsin A Substrates

• Other Protein Substrates

• Other Related Products

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