BOC Sciences is committed to providing a variety of synthetic amino acids to help with our customers’ research. We also provide the asymmetric synthesis of amino acids. BOC Sciences always places scientific research and the needs of our customers first.
Asymmetric synthesis of amino acids is an important part of organic synthetic chemistry, and has been the focus of many chemists and researchers for more than ten years. Nearly 1,000 kinds of non-protein amino acids have been found in nature. With the in-depth study of chiral amino acids, it has been found that the activities of D(-) isomers and L(+) isomers of some substances vary greatly in living organisms. Except for achiral glycine, their stereo configuration is L-type. Asymmetric synthesis methods of amino acids mainly includes resolution, high homologation of L-amino acids, asymmetric alkylation, asymmetric alkylation of imines, and asymmetric hydrogenation of dehydrogenated amino acids. It is cost-effective to synthesize non-natural higher-grade and useful optically pure L- or R-amino acids through the appropriate conversion of inexpensive, readily available natural L-amino acids. Asymmetric amino acid synthesis methods are diverse and unique. Different synthesis methods can often complement each other. For example, asymmetric catalytic hydrogenation for the synthesis of chiral α-amino acids has high yield, high enantioselectivity, atomic economy, and environmental friendliness. Chiral adjuvant-induced alkylation methods can efficiently synthesize quaternary amino acids.
Peptide drugs have been used increasingly in clinics. At least more than 100 peptide drugs have been marketed in the past 20 years, and more than 600 are in the clinical research stage. An important factor restricting the development of peptide drugs is their instability. The introduction of unnatural amino acids into peptides can improve the stability of peptide drugs, and sometimes even increase the drug activity of peptide drugs. In view of this, asymmetric synthesis of amino acids through various methods is of great significance for the development of peptide drugs. Methods of enantioselective alkylation on the α-carbon of amino acids to form quaternary carbon centers have been reported, but the method of introducing aryl groups on the α-carbon of amino acids to prepare valuable α-aryl quaternary amino acids is very rare. This method not only can obtain aryl amino acids that cannot be obtained using classical methods, but also has wider potential for application in synthesis.