Chiral resolution of amino acids

Most of the purposes for which amino acids are needed call for resolved samples of the chiral amino acids. There are major limitations of supply involved in the dependence on a natural source for uncommon amino acids, and asymmetric synthesis has yet to be developed into a reliable general process. In any case, synthesis followed by resolution is usually a more attractive proposition for the supply of novel or uncommon amino acids in required amounts since, even if the other methods are at first sight more convenient, these also require separation stages and checks of optical purity. Here, BOC Sciences provide chiral resolution of amino acids.

Chiral-resolution-of-amino-acids

Introduction

Amino acids are the basic units that make up proteins. They are widely used in medicine, food and cosmetics industries. Most amino acids contain a chiral center. The two enantiomers of D-type and L-type have different physiological activities. Among them, L-amino acids can be directly used by the human body, and D-type amino acids must be converted into L-types in the body before being absorbed and utilized. Different types of D-type amino acids have different amounts and degrees of transformation in the body. Exceeding the conversion limit of this type of amino acid can result in D-type amino acids poisoning. Synthetic amino acids are mostly racemic amino acids. Chiral resolution of amino acids is of great significance for the production of related drugs and foods.

Application

The D-type amino acids are favored by medical workers. Amino acids antibiotics mixed with D-type amino acids are difficult to be degraded by bacteria without causing resistance. This will undoubtedly provide a broader prospect for the use of antibiotics. At present, there are about 1,900 medicines used in the world, of which chiral medicines account for more than 50%; of the 200 commonly used medicines in clinic, more than 110 kinds are chiral medicines; more than 2/3 of the drugs under development are chiral. The preparation of enantiomerically pure chiral compounds is of great significance in the fields of life sciences, medicinal chemistry, fine chemistry, and materials chemistry.

Our Services

  • Chemical resolution
  • Membrane resolution
  • Chromatographic resolution
  • Enzymatic resolution
  • Induced crystallization
  • Extraction resolution
  • Capillary electrophoresis resolution

Our advantages

  • A complete solution
  • Innovative products
  • Quality service
  • High repeatability between batches
  • Stable and reliable product quality
  • Low price

Reference:

  1. Bhushan, R. , & H. Brückner. (2004). Marfey's reagent for chiral amino acid analysis: a review. Amino Acids, 27(3), 231-247.
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