Custom Synthesis of Amino Acids
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Custom Synthesis of Amino Acids

BOC Sciences is committed to providing a variety of synthetic amino acids to help with our customers’ research. We are fully equipped to meet the needs of customers.

Custom-Synthesis-Amino-Acids

Introduction

Proteins can perform a series of significant functions with only 20 natural amino acids. These natural amino acids carry a limited number of functional groups, restricting the function of proteins in chemical and biological science research and applications. Structure modification of proteins through chemical modification, genetic site-directed mutation, and computer-aided protein design has given new functions to natural proteins, but is still limited to natural amino acids. Unnatural Amino Acids, which artificially impart diverse functional groups, are prominent in protein modification. These non-natural amino acids contain keto, aldehyde, azide, alkynyl, alkenyl, amido, nitro, phosphate, sulfonate and other functional groups, and can also be modified. Modifying unnatural amino acids of proteins brings new opportunities for theoretical research and applications. BOC Sciences can synthesize more than 2000 amino acid derivatives, of which our customers can request for customization.

Asymmetric synthesis of amino acids is an important part of custom synthesis of amino acids. The methods mainly include resolution, high homologation of L-amino acids, asymmetric alkylation, asymmetric alkylation of imines, and asymmetric hydrogenation of dehydrogenated amino acids. Asymmetric amino acid synthesis methods are diverse and unique. Different synthesis methods can often complement each other. For example, asymmetric catalytic hydrogenation for the synthesis of chiral α-amino acids has high yield, high enantioselectivity, atomic economy, and environmental friendliness. Chiral adjuvant-induced alkylation methods can efficiently synthesize quaternary amino acids.

Application

An important factor restricting the development of peptide drugs is the instability of peptide drugs. The introduction of unnatural amino acids into peptides can improve the stability of peptide drugs, and sometimes even increase the drug activity of peptide drugs. In view of this, asymmetric synthesis of amino acids through various methods is of great significance for the development of peptide drugs. Methods of enantioselective alkylation on the α-carbon of amino acids to form quaternary carbon centers have been reported, but the method of introducing aryl groups on the α-carbon of amino acids to prepare valuable α-aryl quaternary amino acids is very rare. This method not only can obtain aryl amino acids that cannot be obtained using classical methods, but also has wider potential for application in synthesis. Custom Synthesis Amino Acids has a purity of 95% to 99%. A variety of technologies such as nuclear magnetic resonance, HPLC, IR, UV, LCMS are used for analysis to meet customer requirements.

Our Services

We provide asymmetric synthesis of amino acids to aid our customers' research. The asymmetric synthesis methods of amino acids mainly include splitting of L-amino acids, high homology, asymmetric alkylation, asymmetric hydrogenation of dehydroamino acids, etc.

We use chemical synthesis to prepare substrates for enzyme reactions, and then use enzyme biocatalysis to produce amino acids with low cost and high optical purity. We can achieve cysteine, phenylalanine, lysine, tryptophan, aspartic acid, tyrosine, 5-hydroxytryptophan, dopa (dihydroxyphenylalanine), gamma- Production of GABA, etc.

With strong research and development capabilities and advanced technical equipment, we use protein or protein-containing substances as raw materials to extract glutamic acid, threonine, phenylalanine and other amino acids after acid, alkali or enzyme hydrolysis.

With the help of professional engineering methods and production processes, we can provide direct fermentation synthesis of amino acids, fermentation synthesis with intermediates added, and corresponding efficient purification services.

Based on amino acid phosphorylation, N-glycosylation, O-glycosylation, hydroxylation, methylation, acetylation, and selenization modification strategies, we can quickly and effectively provide modified amino acids to global customers.

We provide customers with tailor-made amino acids using traditional or innovative synthetic methods for cost-effective large-scale production. The amino acids we synthesize have good pharmacological activity and can be used in the research and development of drugs, nutritional products and animal feed.

In solid-phase synthesis, in order to obtain the ideal target peptide, it is first necessary to protect the active groups of amino acids. We provide protection and deprotection services for amino, carboxyl and side chain reactive groups of amino acids. Based on efficient services, we also synthesize free amino acids, protected amino acids, peptides and their derivatives with high quality and low price.

Amino acids are amphoteric substances, and their amino and carboxyl groups can undergo protonation reactions. We can provide amino acid protonation protection, protonation prediction and isoelectric point determination services. The protonation reaction of amino acid can protect its amino group from being oxidized. Predicting the protonation of amino acids is important for protein homology modeling. Based on capillary isoelectric focusing (cIEF) technology, we can realize the determination of the isoelectric point of any amino acid.

Amino alcohols, also known as alkanolamines, are compounds that contain both an amino and hydroxyl functional group in the same molecule, which are used in pharmaceuticals, agrochemicals, and material industries. The synthesis of amino alcohols involves the complex stereochemistry and could be challenging. At BOC Sciences, we provide efficient and reliable amino alcohol synthesis services to meet the diverse needs of our customers.

BOC Sciences offers PEGylation of amino acids as a service to our customers. With our expertise and state-of-the-art equipment, we can ensure high-quality products and services that meet your requirements. We also offer a wide range of amino acids and PEG molecules to choose from.

Our Advantages of Amino Acids Synthesis

  • Complete range of customized amino acid
  • Advanced equipment
  • Well-trained employees
  • Guaranteed quality
  • Competitive Price
  • Excellent one-stop service

Reference:

  1. Shenoi, R. A. . (2018). Engineering of Biomaterials for Drug Delivery Systems || Sugar-based systems.
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