BOC Sciences offers comprehensive amino acid synthesis services, covering both natural and a wide range of non-natural amino acid derivatives. While natural proteins are composed of only 20 standard amino acids with limited functional diversity, non-natural amino acids introduce novel functional groups such as keto, aldehyde, azide, alkyne, alkene, amide, phosphate, sulfonate, and more. These modifications expand the chemical versatility of proteins, enabling new possibilities in biochemical research, protein engineering, and drug discovery. BOC Sciences supports the synthesis of over 6,000 amino acid derivatives and provides fully customizable services to meet specific structural, functional, and optical purity requirements for academic and industrial applications.
We offer professional amino acid synthesis services covering various methods, including solid-phase synthesis, liquid-phase synthesis, and enzymatic catalysis, tailored to diverse customer needs. Whether for small-scale laboratory synthesis or large-scale industrial production, we provide efficient, customized solutions to ensure product purity and stability, supporting smooth progress in research and industrial applications.
BOC Sciences offers custom asymmetric synthesis of amino acids with high enantiomeric purity, supporting pharmaceutical and agrochemical development through chiral catalysis, enzymatic resolution, and advanced stereoselective methods for both natural and non-natural amino acid derivatives.
We chemically synthesize substrates and apply enzyme biocatalysis to produce cost-effective, high-purity amino acids such as cysteine, phenylalanine, lysine, tryptophan, tyrosine, 5-HTP, DOPA, GABA, and others with excellent optical selectivity.
With strong research and development capabilities and advanced technical equipment, we use protein or protein-containing substances as raw materials to extract glutamic acid, threonine, phenylalanine and other amino acids after acid, alkali or enzyme hydrolysis.
With the help of professional engineering methods and production processes, we can provide direct fermentation synthesis of amino acids, fermentation synthesis with intermediates added, and corresponding efficient purification services.
We provide customers with tailor-made amino acids using traditional or innovative synthetic methods for cost-effective large-scale production. The amino acids we synthesize have good pharmacological activity and can be used in the research and development of drugs, nutritional products and animal feed.
BOC Sciences provides tailored amino alcohol synthesis services, utilizing chiral resolution, asymmetric reduction, and reductive amination to deliver structurally diverse, optically pure amino alcohols for use in drug discovery, API development, and fine chemical production.
Unnatural amino acids are artificially synthesized amino acids whose structure is different from natural amino acids. Some are introduced into natural amino acids to improve their performance, while others are completely different from natural amino acids and are the result of molecular design. In recent years, due to the increasingly in-depth research on the role of amino acid peptides and proteins in life activities, and the discovery of more and more active peptides with biological functions, synthetic methods have increasingly become a very useful method to study the relationship between structure and function. Based on this, BOC Sciences offers a fast track to unnatural amino acid synthesis involving custom synthesis of amino acids with unnatural side chains or modifications. Customers can request custom modifications of existing amino acids to meet your needs.
In addition, BOC Sciences offers high-quality preparation services for natural amino acids, ranging from small-scale synthesis to large-scale production. We employ a variety of synthesis techniques, including chemical synthesis, biocatalysis, and enzymatic transformation, to ensure high purity and excellent optical selectivity. Our services cover standard amino acids as well as their isotopically labeled, protected, and salt forms, which are widely used in peptide synthesis, drug development, nutritional research, and metabolic analysis. BOC Sciences also provides customized solutions tailored to client needs, ensuring structural accuracy, consistent quality, and efficient delivery.
| Amino Acid Types | Preparation Methods | Amino Acid Types | Preparation Methods |
| L-Valine | Fermentation, synthesis | Glycine | Synthesis |
| L-Leucine | Chemical hydrolysis, fermentation | D,L-Alanine | Synthesis |
| L-Isoleucine | Fermentation | L-Alanine | Fermentation, enzymatic method |
| L-Threonine | Fermentation | L-Serine | Fermentation |
| D,L-Methionine | Synthesis | L-Glutamic Acid | Fermentation |
| L-Methionine | Synthetic method, enzymatic method | L-Glutamine | Fermentation |
| L-Phenylalanine | Synthetic method, enzymatic method | L-Proline | Fermentation |
| L-Lysine | Fermentation, enzymatic hydrolysis | L-Hydroxyproline | Chemical hydrolysis |
| L-Arginine | Fermentation, enzymatic hydrolysis | L-Ornithine | Fermentation |
| L-Aspartic Acid | Fermentation | L-Citrulline | Fermentation |
| L-Cysteine | Chemical hydrolysis | L-Tyrosine | Chemical hydrolysis |
Table 1. Representative natural amino acids.
Demand Communication
We engage in in-depth communication with customers to understand the types of amino acids, purity levels, quantities, and any special customization requirements, ensuring clear project objectives and laying the foundation for precise preparation plans.
Solution Design
Based on customer needs and project characteristics, we develop reasonable and efficient synthetic routes and process workflows, fully considering cost, time, and product performance to ensure the plan is scientific and feasible.
Raw Material Procurement
We procure starting materials and reagents that meet high-quality standards, strictly select suppliers, and ensure the purity and stability of raw materials to provide reliable support for the synthesis process.
Synthesis Preparation
Utilizing advanced equipment and a professional technical team, we strictly control reaction conditions to achieve efficient amino acid synthesis, ensuring the product meets the customer's expected quality standards.
Purification and Testing
Multi-step purification processes are employed to effectively remove impurities. Various analytical methods such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS) are used to ensure the final product's purity and quality meet standards.
Packaging and Delivery
According to product characteristics and customer requirements, appropriate packaging materials and methods are used to ensure product stability and safety. Fast logistics are arranged to guarantee timely delivery.
As fundamental building blocks of proteins, amino acids are key raw materials for synthesizing peptide drugs and protein-based therapeutics. The preparation of high-purity amino acids supports new drug development, targeted drug design, and the production of biomacromolecular drugs, enhancing efficacy and safety to meet clinical treatment requirements.
Amino acids are essential nutrients for the human body and are widely used in nutritional supplements and functional health products. Producing high-purity amino acids helps improve product bioavailability, promotes protein synthesis, enhances immunity, and supports physical strength and recovery, thereby fulfilling the needs of sports nutrition and health management.
In food processing, amino acids serve as flavor enhancers, nutritional fortifiers, and food additives. Synthetic amino acids can improve food taste and flavor while increasing nutritional value. Additionally, customized amino acid derivatives meet the functional requirements of specialty foods, such as infant formula and medical nutrition products.
Due to their excellent moisturizing properties and ability to promote skin repair, amino acids are widely used in skincare and cosmetic products. High-purity amino acids produced via synthesis technologies help improve product stability and safety, stimulate collagen synthesis, and enhance skin elasticity and radiance.
Amino acids are important components of biodegradable and smart materials, extensively applied in tissue engineering and medical devices. Customized amino acid synthesis can regulate material properties such as strength, biocompatibility, and degradation rate, advancing the research and application of novel biomaterials.
High-purity amino acids are fundamental reagents in life science research, used for protein structure analysis, enzymology, and metabolic pathway studies. Synthetic amino acids can meet special laboratory demands for isomers, labeled amino acids, and more, supporting basic research and new technology development.
An important factor restricting the development of peptide drugs is the instability of peptide drugs. The introduction of unnatural amino acids into peptides can improve the stability of peptide drugs, and sometimes even increase the drug activity of peptide drugs. In view of this, asymmetric synthesis of amino acids through various methods is of great significance for the development of peptide drugs. Methods of enantioselective alkylation on the α-carbon of amino acids to form quaternary carbon centers have been reported, but the method of introducing aryl groups on the α-carbon of amino acids to prepare valuable α-aryl quaternary amino acids is very rare. This method not only can obtain aryl amino acids that cannot be obtained using classical methods, but also has wider potential for application in synthesis. Custom synthesis amino acids have a purity of 95% to 99%. A variety of technologies such as nuclear magnetic resonance, HPLC, IR, UV, LC/MS are used for analysis to meet customer requirements.
The manufacture of amino acids began with protein hydrolysis in 1820, and chemical synthesis of amino acids in 1850. Until 1957, Japan successfully produced glutamic acid through fermentation, which also promoted the development of the world's amino acid industry. Currently, amino acid production methods are divided into two categories: synthesis and hydrolysis.
Among these four methods, fermentation and enzymatic hydrolysis are the most widely used in amino acid production due to their economic feasibility and ecological advantages. Advances in fermentation technology and improvements in microbial production strains have enabled the industrial large-scale production of amino acids. In addition, the selection of the amino acid preparation process should fully take into account the characteristics of the raw materials themselves. For example, feather protein waste is mainly composed of keratin. Keratin contains a high amount of cysteine (14%-15%), resulting in a high content of disulfide bonds. The fibers are cross-linked by disulfide bonds and hydrogen bonds, making them chemically stable and mechanically strong. Therefore, they need to undergo high temperature, high pressure, acidic, alkaline, or enzymatic treatment to break down into peptides or free amino acids for livestock and poultry utilization. Enzymatic hydrolysis cannot meet the requirements of the process, so the hydrolysis of feather keratin typically involves a more intense acidic hydrolysis method.
