We lead in peptide science research and application while offering precise and efficient C-terminal modification services for research organizations and businesses. Our professional research team utilizes advanced technology platforms to deliver multiple C-terminal modification techniques such as amidation, biotin labeling, fluorescence labeling, phosphorylation, and PEGylation which address various requirements in drug development and biomedical research as well as diagnostic reagent development. Through our dedication to high quality standards, absolute purity control, and quick delivery times we guarantee each modified peptide fulfills strict specifications thereby supporting your innovative research and product development.
The modification replaces the carboxyl group at the peptide's C-terminal with an amide group to improve peptide stability and extend its effect duration. The peptide drug development field frequently utilizes this method.
The C-terminal of peptides can be tagged with biotin which enables specific interactions with avidin or streptavidin to facilitate capture, separation, and detection. The technique enables biomedical research to investigate how peptides function physiologically and understand their underlying mechanisms.
Researchers apply fluorescent dyes or groups to peptide C-terminals to track their distribution, metabolism and interactions effectively within the body. This approach finds frequent application in cell imaging as well as fluorescence resonance energy transfer methodologies among other areas.
The addition of phosphate groups to certain amino acid residues at peptide C-termini controls biological functions by influencing receptor binding and cell signal transduction as well as protein interactions. Researchers use this process to study cell signaling pathways.
The process of attaching polyethylene glycol (PEG) molecules to peptide C-termini serves multiple purposes such as enhancing water solubility and stability and prolonging circulation half-life while reducing immunogenicity and non-specific binding and decreasing renal clearance.
Peptides achieve their three-dimensional structure through disulfide bonds that form between their C-terminal and other cysteine residues which enhance thermal stability, chemical stability and biological activity. This method works well with peptides that need precise structural shapes.
Peptides utilize stable isotopes like 13C and 15N which bond to amino acids or chemical groups at their peptide C-terminal. Scientists use this approach to investigate metabolic pathways of peptides as well as protein synthesis and degradation kinetics and to analyze biomolecular interactions and internal standards for mass spectrometry analysis.
Peptides have small biological molecules linked to their C-terminal end which confer new properties or strengthen existing ones including targeting capability or enzyme blocking functions. The technology enables the development of new peptide-based pharmaceuticals.
Protein carriers like bovine serum albumin (BSA) or keyhole limpet hemocyanin (KLH) are connected to peptides at their C-terminal to boost immunogenicity which triggers the production of specific antibodies by the body. This process is frequently employed during vaccine development, antibody production and immunoassay procedures.
| Amidation | Alcohol | BSA conjugation on C terminal -COOH |
| AMC | Bzl | OVA conjugation on C terminal -COOH |
| Cysteamide | EDA-Biotin | KLH conjugation on C terminal -COOH |
| Ester (OEt) | Ester (OMe) | Tyr (3-NO2) |
| Glu(EDANS) | Hydrazine | p-Nitroanilide |
| MPAA | NHEt | TBzl |
| Nhisopen | NHMe | NHMe |
Client Consultation and Requirement Confirmation
Clients can consult us through various channels. After understanding their C-terminal modification needs, we offer an initial technical solution and quotation. Once both parties reach an agreement, a contract is signed.
Peptide Synthesis and Modification
Based on the customized peptide sequence provided by the client, we synthesize the peptide using the appropriate technology and then apply professional modification techniques to precisely modify the C-terminal.
Quality Testing
After modification, the peptide undergoes strict quality testing, including purity analysis and molecular weight determination, to ensure that all specifications meet the client’s requirements.
Delivery and After-Sales
The qualified peptide products are delivered to the client along with a detailed testing report. We also provide comprehensive after-sales support, quickly resolving any issues that may arise during the use of the product.
Professional Technical Team Our experienced team specializes in peptide synthesis and modification. We manage every step of C-terminal modification with precision, from designing synthesis routes to optimizing reaction conditions.
Diverse Modification Techniques We offer a wide range of C-terminal modification techniques, including amidation, biotin/fluorescence labeling, phosphorylation, PEGylation, disulfide bond formation, isotope labeling, small molecule modification, and protein conjugation.
Strict Quality Control We prioritize quality in every phase, from selecting raw materials to real-time monitoring during synthesis and ensuring purity and molecular weight after modification. Every peptide meets the highest standards for research or industrial use.
Efficient Delivery We optimize our processes using advanced project management and automation, ensuring faster delivery while maintaining high quality. We respond quickly to urgent or large-scale orders, saving valuable time.
Comprehensive Confidentiality System We prioritize client confidentiality and IP protection. We sign non-disclosure agreements and encrypt sensitive information, ensuring your research and business development remain secure.
Expert After-Sales Service Our dedicated support team is available 24/7 to address any technical issues and provide guidance. We also follow up with clients to gather feedback and continually improve our services, aiming to be your long-term partner for C-terminal modifications.
Enhancing Stability: C-terminal modification, like amidation, helps peptides resist degradation, improving stability and prolonging their effectiveness in the body.
Optimizing Pharmacokinetics: Modifying peptide properties (like hydrophilicity) can enhance absorption, distribution, metabolism, and excretion, making drugs more effective at reaching target sites.
Enhancing Bioactivity: C-terminal modifications improve peptide binding to receptors, boosting biological activity, like increasing the effectiveness of human parathyroid hormone (hPTH).
Protein Structure and Function: Modified peptides help study protein folding, stability, and interactions, offering insights into protein mechanisms.
Cell Signaling Research: C-terminal modifications affect peptide interactions with cell membranes and receptors, aiding studies on cell signaling and disease treatment.
Antimicrobial Peptide Research: Modifying C-terminals enhances the activity and stability of antimicrobial peptides, improving their effectiveness against harmful bacteria.
Biomarker Detection: C-terminal modified peptides can create specific antibodies for high-sensitivity biomarker detection in diagnostics.
Imaging Diagnosis: Fluorescence or other labels on C-terminal modified peptides help create imaging probes to visualize disease sites in the body.
Peptide-Drug Conjugates: C-terminal modifications enable linking peptides with drugs, enhancing targeted treatment and synergy between the peptide and drug.
Enhancing Drug Targeting: Modified peptides act as carriers to deliver drugs directly to diseased areas, reducing side effects and improving treatment efficiency.
Yes, we can customize specific modifications based on your requirements.
Modified peptides undergo strict quality control, including purity analysis and molecular weight determination, to ensure they meet the required standards.
We provide HPLC and MS test reports, and upon request, we can also provide peptide content testing reports.
C-terminal modification can enhance peptide stability, extend its action time in the body, and potentially increase its bioactivity.
It may decrease solubility, but the specific impact depends on the type of modification and the peptide sequence.
