We provide professional peptide conjugation services, dedicated to solving the complex conjugation challenges in peptide drug development for global research institutions and pharmaceutical companies. With advanced technology platforms and an experienced research team, we offer one-stop services ranging from peptide synthesis to efficient conjugation with various molecules, meeting the needs of drug development, diagnostic reagent development, and more.
The drug cannot accurately target the diseased area, leading to side effects on normal tissues, affecting the drug's safety and efficacy, and delaying your project progress.
The drug is easily degraded or metabolized in the body, affecting the therapeutic effect and duration of action, increasing uncertainty and cost in development, making your budget difficult to control.
Peptide drugs have high immunogenicity, triggering immune responses in the body, limiting their clinical applications, potentially leading to project failure or resource waste, and affecting your return on investment.
It is difficult to meet the needs of complex disease treatments that require multiple functions and enhanced therapeutic effects, limiting the drug's market competitiveness and application scope, making it hard for your product to stand out.
Conjugating targeting peptides with antitumor small molecule drugs enhances the tumor targeting capability of the drug and reduces its toxicity to normal tissues. For example, conjugating peptides with drugs like paclitaxel and doxorubicin increases their accumulation and efficacy at tumor sites.
By conjugating antimicrobial peptides with traditional antibiotics, the antibacterial activity and penetration ability of the antibiotics are enhanced, effectively combating drug-resistant strains. For instance, conjugating vancomycin with membrane-targeting peptides strengthens its ability to kill resistant strains like methicillin-resistant Staphylococcus aureus (MRSA).
Conjugating peptides with neuroprotective agents or neurotransmitter drugs improves the drug’s penetration and duration of action in the central nervous system, which is useful for treating neurodegenerative diseases or psychiatric disorders.
By conjugating peptides with monoclonal antibodies that have specific targeting capabilities, bifunctional molecules are formed. These molecules can bind to target cell surface antigens via the antibody and enter the cells through the peptide, improving the drug's therapeutic effects. For example, combining tumor-targeting antibodies with cell-penetrating peptides enhances the drug’s ability to kill tumor cells.
Linking peptides with carrier proteins such as BSA and KLH for immunogen preparation, enhancing the immunogenicity of peptides and producing specific antibodies.
Connecting peptides with enzymes to develop novel biocatalysts for use in biosensors, disease treatment, and other fields.
Conjugating peptides with viral vectors enhances the targeting and infectivity of the viral vectors, which is useful in gene therapy. For example, conjugating peptides with adeno-associated virus (AAV) vectors increases the efficiency and specificity of gene delivery.
Linking peptides with DNA, RNA, oligonucleotides, and other nucleic acid molecules to create peptide-nucleic acid complexes for gene therapy, nucleic acid vaccine development, and more.
Connecting peptides with different functions to create multifunctional peptides, such as dual-target peptides and peptide dimers, expanding the application range of peptides.
Conjugating polyethylene glycol (PEG) with peptides increases their solubility, stability, and half-life, and reduces immunogenicity. This is suitable for peptides that require prolonged in vivo action.
Adding fluorescent groups to peptides for biological imaging, cell tracking, and other research, aiding in drug screening and disease diagnosis.
Linking biotin to peptides for affinity purification, ELISA detection, and other experiments, improving sensitivity and specificity in detection.
This includes substitutions with non-natural amino acids, D-amino acids, or modified amino acids to improve peptide stability and bioactivity.
Modifications such as pseudo-peptides, peptoids, or the introduction of cyclic structures (e.g., cyclic peptides, stapled peptides, disulfide bonds) are made to enhance peptide stability and druggability.
Introducing fatty acid chains into the side chain or backbone of peptides alters their physicochemical properties and bioavailability.
Stable non-radioactive isotopes like 2H, 15N, and 13C are used to label peptides for nuclear magnetic resonance (NMR) experiments, facilitating detection and analysis.
Project Consultation
You provide us with detailed information, including peptide sequence, conjugate molecule type, and intended use. Based on your requirements, we will conduct an initial evaluation and provide a professional quotation and project proposal within 24 hours.
Contract Signing
After both parties confirm the project details, we will sign a technical service contract that clarifies the rights and obligations of both parties.
Project Launch
Upon receiving the prepayment, we will arrange a professional team to initiate the project, starting with peptide synthesis and purification to ensure high quality and purity.
Conjugation Reaction Optimization
Based on the characteristics of the conjugate molecules, we will choose appropriate linkers and conjugation methods, optimizing the reaction conditions to ensure conjugation efficiency and product stability.
Quality Control
We will conduct comprehensive quality testing on the conjugation products, including purity, molecular weight, and activity, to ensure the product meets your requirements.
Delivery and After-Sales Service
We will deliver the qualified conjugation products in lyophilized powder form and provide a complete quality control report. Additionally, we offer after-sales technical support to address any issues you encounter during usage.
Includes solid-phase synthesis, liquid-phase synthesis, combined solid-liquid phase synthesis, and non-classical solid-phase synthesis technologies, enabling the efficient synthesis of high-quality peptides.
Capable of non-natural amino acid synthesis and peptide modification, providing diversified foundations for peptide conjugation.
Covers lysine-site conjugation, cysteine-site-specific conjugation, non-natural amino acid conjugation, glycosylation conjugation, click chemistry conjugation, and other techniques, allowing customized conjugation reactions based on customer needs.
Includes membrane concentration/separation technology, ion exchange chromatography, and normal-phase and reversed-phase preparative HPLC technologies, ensuring high purity and high quality of conjugated products.
Equipped with advanced analytical instruments such as mass spectrometry (MS) and high-performance liquid chromatography (HPLC), enabling comprehensive quality inspection and analysis of peptides and conjugated products to ensure compliance with quality requirements.
Professional R&D TeamOur team consists of experienced peptide chemists and drug development experts with extensive experience in peptide conjugation projects, capable of handling complex technical challenges.
Advanced Technology PlatformEquipped with internationally leading peptide synthesis instruments, purification equipment, and analytical instruments, we ensure the high quality and purity of peptides and conjugation products.
Rich Project ExperienceWe have successfully completed numerous peptide conjugation projects across fields such as drug development and diagnostic reagent development, accumulating a wealth of successful cases.
Strict Quality ControlFrom raw material procurement to product delivery, we strictly control the quality at every step to ensure compliance with international standards and customer requirements.
Fast Delivery Cycle
Peptide-drug conjugates (PDCs) have broad potential in cancer treatment. By targeting specific receptors on tumor cells, they deliver cytotoxic agents for precise treatment, minimizing damage to normal cells.
Peptides are used as drug carriers for delivering small molecule drugs, nucleic acids, radioactive isotopes, etc., enhancing drug stability, targeting, and therapeutic effects.
Peptide-conjugated nucleic acid drugs are used in gene therapy by targeting specific cells to deliver nucleic acids for gene editing or gene silencing.
Peptide-conjugated immune agonists are used to activate the immune system, enhancing the immune response against tumor cells.
Peptide-conjugated radioactive isotopes are used for precise disease diagnosis. By binding to specific receptors on tumor cells, they help locate malignant tissues by detecting signals released from radioactive isotopes.
Peptide conjugation technology is used in vaccine development by linking antigens to peptide carriers, enhancing vaccine immunogenicity and efficacy.
Peptide conjugated with fluorescent labels, biotin, etc., is used for biomarker detection and research tools to support biomedical research.
We have a specialized conjugation technology team that selects appropriate linkers and conjugation methods based on the characteristics of the peptides and target molecules. By optimizing reaction conditions (such as pH, temperature, and reaction time), we enhance conjugation efficiency. Additionally, we conduct comprehensive mass spectrometry analysis and activity tests to ensure that the conjugation efficiency meets the expected goals.
During the conjugation reaction design, we fully consider the active sites of the peptide and choose linker positions that do not affect its activity. We also conduct a series of bioactivity assays to verify the activity of the conjugation products, ensuring they maintain good biological activity after conjugation.
We provide a variety of linkers, including but not limited to pH-sensitive, redox-sensitive, and enzyme-sensitive linkers. Based on your project requirements and the characteristics of the target molecules, we will recommend the most suitable linker types and provide customized design and synthesis.
We use advanced purification technologies and equipment, such as high-performance liquid chromatography (HPLC) and gel permeation chromatography (GPC), for multi-step purification of conjugated products. Additionally, we provide complete purity testing reports, ensuring transparency of the product quality.
Yes, we have a professional stability testing platform that can evaluate the stability of conjugation products under various conditions, including solution stability, lyophilization stability, and long-term storage stability. Based on the test results, we will provide the best storage and usage recommendations to ensure product stability in actual applications.
We are customer-oriented and have a comprehensive project management and after-sales service system. During the project, we regularly communicate with you regarding progress and address any issues promptly. If problems arise, we immediately organize a professional team to analyze and resolve them, ensuring smooth project advancement. Additionally, we provide after-sales technical support to answer any questions you encounter during usage.
