We are excited to introduce our Peptide Drug Conjugates (PDC) services as a professional peptide service company to provide your peptide drug development with new impetus. Our advanced production facilities combined with powerful R&D capabilities allow us to completely fulfill your requirements for peptide drug conjugation. Our professional team oversees each step in the complete process of drug design through peptide synthesis and modification to conjugation to maintain high quality and efficiency. We ensure our clients experience close collaboration while we deeply understand their needs and deliver tailored solutions. Our team offers professional service and high-quality support during preclinical research and large-scale commercialization for peptide drug development.
Traditional medications frequently fail to accurately target cancerous cells which results in collateral damage to healthy tissue.
Drugs break down easily in the body which affects their effectiveness and safety.
The harmful effects of drugs on healthy cells restrict their possible clinical uses.
The development of peptide drugs requires interdisciplinary collaboration and entails complex procedures that extend over prolonged periods.
PDCs present difficult detection and analysis because they possess complex structures together with high quality standards.
We offer high-quality peptide synthesis services, ranging from conventional peptides to modified peptides. Our synthesis team is highly skilled and capable of large-scale synthesis and modification of peptides, laying a solid foundation for PDC development. We use advanced synthesis technologies and purification processes to ensure the high purity and stability of peptide products, meeting various PDC development needs.
Linkers are a key component of PDCs, directly affecting the drug's stability and release characteristics. Our expert team understands the critical impact of linkers on PDC performance and can design stable and highly specific linkers based on the drug's characteristics and mechanisms of action. We combine computer-aided design with experimental validation to ensure the linker can accurately release the drug in vivo while maintaining the drug's stability.
We precisely conjugate cytotoxic drugs, bioactive molecules, and other effective payloads with peptides to achieve efficient drug delivery. Our conjugation technology is mature and reliable, ensuring stable linkage between the drug payload and the peptide, without affecting the drug's activity. We offer multiple conjugation solutions to meet the needs of different drug payload types.
Using advanced analytical technologies such as mass spectrometry, HPLC, and others, we provide comprehensive characterization and quality control of PDCs, including their structure, purity, and stability. Our analysis team has extensive experience and can accurately detect key parameters such as molecular weight, amino acid sequence, and purity, ensuring that the product quality meets international standards. We also provide detailed analysis reports to help you understand the quality status of your product.
We offer pharmacodynamics evaluation from in vitro experiments to in vivo animal models, as well as drug metabolism and pharmacokinetics research services, supporting decision-making at various stages of drug development. Our research team has rich experimental experience and professional technical capabilities to design reasonable experimental plans and accurately assess the pharmacodynamics and safety of PDCs. We also provide data statistics and analysis services to help you better understand the research results.
Project Consultation and Needs Assessment
Clients present their PDC development needs, and we will engage in in-depth communication to assess the technical feasibility and define the collaboration plan.
Solution Design and Quotation
Based on the client's requirements, our professional team will design a detailed PDC development plan, including peptide sequence design, linker selection, drug payload types, etc., and provide a corresponding quotation.
Project Initiation and Execution
After signing the contract, we will swiftly initiate the R&D process, from peptide synthesis and drug payload conjugation to subsequent characterization analysis and pharmacological studies, all carried out strictly according to the established plan.
Quality Control and Delivery
Throughout each project phase, we perform rigorous quality control to ensure that the delivered PDC products meet the required quality standards and development specifications. Final products and related reports will be delivered to the client.
After-Sales Support and Communication
After the project is completed, we continue to monitor client feedback, providing necessary after-sales technical support and addressing any issues encountered in subsequent development stages.
This platform integrates solid-phase synthesis together with liquid-phase synthesis and combined solid-liquid phase synthesis and non-classical solid-phase synthesis technologies to achieve efficient high-quality peptide production.
This platform performs peptide modification while synthesizing non-natural amino acids which creates diverse bases for peptide conjugation.
The platform supports lysine-site conjugation alongside other methods including cysteine-site-specific conjugation and click chemistry conjugation to enable customized conjugation reactions that meet customer specifications.
The drug purification technology platform utilizes membrane concentration/separation technology along with ion exchange chromatography and both normal-phase and reversed-phase preparative HPLC technologies to maintain the high purity and quality of conjugated products.
The platform utilizes advanced analytical instruments including mass spectrometry (MS) and high-performance liquid chromatography (HPLC) to perform thorough quality inspections and analyses of peptides and conjugated products while meeting quality standards.
Extensive Peptide Synthesis Experience:Our peptide synthesis team is highly skilled, capable of large-scale synthesis and modification, laying a solid foundation for PDC development.
Professional Linker Design CapabilitiesWe deeply understand the key impact of linkers on PDC performance and can design linkers that meet specific requirements to ensure drug stability and precise release in the body.
Advanced Analytical Testing PlatformEquipped with a range of high-end analytical instruments such as mass spectrometry and HPLC, we conduct comprehensive and accurate analysis of PDC quality to guarantee product excellence.
Efficient One-Stop ServiceFrom peptide synthesis to drug payload conjugation, and from pharmacodynamics to pharmacokinetics studies, we provide a complete and integrated development service, saving clients time and cost.
Strict Quality Control System
PDCs exhibit significant advantages in cancer treatment by precisely targeting tumor cells and reducing damage to normal tissues. By conjugating cytotoxic drugs, PDCs can effectively inhibit tumor growth while minimizing side effects. PDCs can also be applied to tumor immunotherapy, gene therapy, and overcoming anti-tumor resistance.
PDC technology has broad applications in the anti-infection field. By combining peptides with anti-infection drugs, the targeting and efficacy of drugs can be improved, reducing impact on normal cells. Research is exploring PDC applications in antiviral and antibacterial treatments.
In the treatment of respiratory diseases, PDCs can precisely deliver drugs to affected areas, enhancing therapeutic efficacy. PDCs can be used for treating conditions such as asthma and chronic obstructive pulmonary disease (COPD).
PDC technology offers new possibilities for treating rare diseases. Due to the small patient population and high drug development costs, the flexibility and efficiency of PDCs make them an attractive option. By precisely targeting diseased cells, PDCs can effectively improve treatment outcomes.
The PDC development cycle is influenced by factors such as peptide sequence complexity, linker design difficulty, drug payload type, and the progress of pharmacological studies. Generally, from peptide synthesis to drug payload conjugation, it may take several weeks to months; complete pharmacodynamics and pharmacokinetics studies could extend the timeline by several months to over a year. We will create a detailed project plan based on your specific needs to ensure efficient progress.
We optimize the development process, improve synthesis efficiency, and reasonably arrange experiments to effectively control R&D costs while ensuring service quality. Additionally, we provide flexible cooperation plans and quotations based on your budget and project needs to help you achieve your PDC development goals within your budget.
We attach great importance to the protection of clients' intellectual property and implement strict confidentiality measures for all collaborative projects. Before project initiation, we will sign a confidentiality agreement with clients to ensure that provided information and technical materials are not disclosed. During development, we strictly manage core confidential aspects and limit access to unrelated personnel, ensuring a secure collaboration.
Compared to traditional drugs, PDCs have higher targeting capabilities, enabling precise action on diseased cells while reducing damage to normal tissues and minimizing side effects. Additionally, their flexible structural design allows them to carry various types of effective payloads, catering to the treatment of different diseases. Their relatively small molecular weight provides better tissue penetration and distribution characteristics, showing promising application prospects in treating conditions like cancer.
Yes, we understand that every PDC development project is unique, so we provide comprehensive customization services. Whether you're in the early exploratory stage of drug development or already in preclinical or clinical research, we will tailor a development plan to suit your specific needs and help your PDC project progress smoothly.
