Our expertise lies in delivering premium peptide modification services with various options such as terminal modifications and side chain modifications as well as cyclization modifications and fluorescent/biotin labeling alongside D-amino acid substitution to support research as well as diagnostics drug delivery vaccine development and additional applications. We can customize an optimal peptide modification solution to support your research whether your goals are to optimize peptide stability, enhance biological activity or achieve targeted delivery.
| Modification Type | Application Scenarios | Available Labels / Modification Forms |
| N-terminal Modification | Enhance stability, mimic natural peptides, extend in vivo half-life | Acetylation, Biotin, Fluorescent dyes (FITC, FAM), etc. |
| C-terminal Modification | Improve enzymatic resistance, mimic natural sequences, biological conjugation | Amidation, Biotin, C-terminal linker |
| Fluorescent Labeling | Fluorescence imaging, cell localization, receptor binding assays | FITC, FAM, TAMRA, Cy3, Cy5, Alexa Fluorseries |
| Enzyme Labeling | ELISA, immunohistochemistry, enzyme-linked assays | HRP (Horseradish Peroxidase), ALP (Alkaline Phosphatase) |
| Isotope Labeling | Proteomics, metabolic tracking, quantitative analysis | 13C, 15N, 2H, 18O, etc., stable isotopes |
| Phosphorylation | Signal transduction studies, mimic natural intracellular modifications | pSer, pThr, pTyr |
| Methylation | Epigenetics research, transcription regulation mechanisms | Mono/di/tri-methyl-Lys or Arg |
| PEGylation | Extend circulation time, reduce immunogenicity, improve solubility | mPEG (2kDa, 5kDa, 10kDa), linear or branched PEG |
| KLH/BSA Conjugation | Antibody preparation, immunoassays | KLH, BSA, OVA (via maleimide or glutaraldehyde conjugation) |
| Lipid Conjugation | Targeted delivery, membrane transport, peptide vaccine design | Cholesterol, palmitic acid, stearic acid, fatty acid chains |
| Cyclization Modification | Enhance stability, maintain conformation, improve affinity | Head-to-tail cyclization, disulfide bonds, side-chain to side-chain cyclization (e.g., "stapled peptides") |
| Non-natural Amino Acids | Enzyme resistance, peptide optimization, enhanced targeting function | D-amino acids, β-amino acids, N-methylated amino acids |
We are committed to making peptide modifications efficient, controllable, and transparent, with every step traceable and communicable.
Needs Communication and Sequence Assessment
Clients submit peptide sequences, target modifications, and application scenarios. We provide feasibility assessments and suggestions for modifications.
Quotation and Order Confirmation
After confirming the plan, we generate a formal quotation. Client confirms and places an order. The project is initiated and synthesis process begins.
Synthesis and Modification Implementation
Peptide synthesis and modification process optimization. Standard purification (HPLC) and quality control analysis (MS).
Delivery and Quality Control Report
Quality control report sent to the client for pre-review before product delivery. Upon confirmation, shipment is arranged. Usage recommendations are provided.
Technical Support and After-Sales Service
We provide post-sale technical support and answer inquiries. In case of quality issues, we support free rework or adjustments to optimize the product.
Customized and Flexible ServicesWe offer a variety of modifications, including terminal, side-chain, cyclization, labeling, and more, tailored to the client’s needs. We support complex modifications and challenging projects.
High Purity and High Success Rate We use advanced solid-phase synthesis and purification techniques, with typical high purity. We provide complete quality control reports, including HPLC and MS data.
Wide Range of Modifications We offer over 300 types of modifications, covering common chemical modifications, special amino acid modifications, labeling modifications, and more. This encompasses nearly all modification types in the peptide modification field. Whether your needs are standard or complex, we can meet them.
Professional Technical Support Our experienced technical team provides advice on modification selection, sequence optimization, and guidance for downstream applications.
Comprehensive After-Sales Guarantee If modification fails or quality does not meet the specifications due to reasons not attributable to the customer, we offer free rework or refunds, ensuring peace of mind for our clients.
| Application Area | Brief Description |
| Drug Delivery | Modifying the chemical properties of peptides to enhance their stability and targeting in the body, improving drug delivery efficiency. |
| Vaccine Development | Using peptide modifications to increase immunogenicity, promote antigen presentation, and enhance vaccine protection. |
| Antibody Preparation | Conjugating peptides with large molecules (e.g., KLH, BSA) to stimulate immune responses and generate specific antibodies. |
| Receptor Research | Modifying peptides to bind with specific cell receptors, aiding in signal pathway analysis and receptor activity studies. |
| Cancer Immunotherapy | Designing modified peptides to stimulate the immune system to recognize tumor cells, boosting anti-tumor immune responses. |
| Biomarker Detection | Fluorescent or enzyme-labeled peptides for clinical detection, immunohistochemistry, Western blotting, and other assays. |
| Drug Candidate Optimization | Introducing non-natural amino acids into peptides to optimize the affinity, stability, or selectivity of drug candidates. |
| Cell Localization and Tracking | Using fluorescent or isotope-labeled peptides to track their localization and behavior within cells, supporting cell biology research. |
| Tissue Engineering and Regenerative Medicine | Modified peptides used to create biodegradable scaffold materials, promoting tissue regeneration and wound healing. |
| Protein-Protein Interaction Research | Peptide modifications help simulate protein-protein interactions, used for screening potential molecular targets and drug candidates. |
| Antimicrobial Peptide Development | Modifying natural antimicrobial peptides to enhance their antimicrobial activity and in vivo stability, used for infection treatment. |
Our high-quality modification techniques maintain peptide stability throughout in vivo and in vitro applications. The N-terminal and C-terminal amidation blocks peptide degradation while PEGylation boosts both solubility and stability. Each peptide product batch receives rigorous quality control through HPLC purity analysis and mass spectrometry (MS) testing to ensure high standards in the delivered products.
Our modification portfolio includes N-terminal and C-terminal modifications along with side-chain modifications, cyclization processes, fluorescent labeling protocols, biotinylation, PEGylation techniques, fatty acid modifications, phosphorylation and methylation options and additional modification types. Your specific needs determine which modification type you should choose or you can ask us to develop a personalized modification plan.
Starting the project requires you to submit the amino acid sequence of the target peptide along with desired modification types, modification goals and application scenarios. The technical team will utilize this information to deliver an initial evaluation and quotation.
We provide a quality guarantee for all modification projects. Each batch of products undergoes rigorous quality control and is accompanied by HPLC and MS quality control reports to ensure purity and accuracy. If any issues arise due to our handling, we offer free rework or a refund guarantee.
Yes, we offer customization services. We can design the most suitable modification plan based on your specific requirements (such as drug delivery systems, vaccine development, etc.). Our team will work closely with you to ensure the final modified product meets your expectations.
Yes, we offer a variety of post-modification functional testing services, such as affinity testing, immunogenicity assessment, cell experiments, etc., to help you verify the effectiveness and stability of the modified peptides in actual applications.
We use mature modification techniques to ensure that the modification process does not affect the peptide's inherent activity. For modifications that may impact activity, we will communicate with the client and make thorough optimizations to ensure that the modified peptide retains its original functionality.
We also offer peptide synthesis services. You can submit your amino acid sequence and modification requirements, and we will provide a complete synthesis and modification plan for you.
