Peptide-oligonucleotide conjugation technology is driving innovation in biomedical research and drug development. We offer high-quality, customized solutions that combine the cell-penetrating ability of peptides with the gene-regulating functions of oligonucleotides, creating novel biomolecules with unique therapeutic potential. This technology is valuable in drug discovery, diagnostic reagent development, and gene therapy. Our expert team provides comprehensive support, from molecular design to synthesis optimization, to help advance your research and drug development projects.
Traditional peptide or oligonucleotide therapeutics often struggle to meet complex treatment demands. Peptide-oligonucleotide conjugation enables the creation of synergistic biomolecules, offering new strategies for tackling difficult-to-treat diseases.
Achieving precise delivery of therapeutic molecules to target cells or tissues remains a bottleneck in drug development. Our tailored conjugation strategies allow for precise molecular modifications, enabling specific recognition and binding to target cell receptors, thereby enhancing drug targeting and therapeutic efficacy.
Peptide and oligonucleotide drugs are often prone to enzymatic degradation in vivo, leading to low bioavailability. Conjugation technology enhances molecular stability, prolonging drug action in the body and reducing dosing frequency.
Based on your research goals and drug design needs, our expert team provides comprehensive custom services, from molecular design to synthesis route planning. Whether simple linear conjugation or complex multifunctional modifications, we deliver precise solutions.
Utilizing advanced solid-phase and liquid-phase synthesis techniques, combined with efficient purification processes, we ensure that synthesized peptides and oligonucleotides achieve high purity and bioactivity, laying a solid foundation for conjugation reactions.
We offer highly specialized conjugation solutions tailored to meet specific therapeutic or research needs. Whether you're working on targeted drug delivery, biomarker discovery, or gene therapy, we can customize our conjugation techniques to suit the precise demands of your project, including functionalized peptides and oligonucleotides with unique properties such as enhanced stability or specific binding capabilities.
We enforce strict quality control standards at every production stage, conducting comprehensive mass spectrometry and high-performance liquid chromatography (HPLC) analysis on synthesized peptides, oligonucleotides, and final conjugated products to ensure they meet your specifications.
Whether your project requires small-scale synthesis for research purposes or large-scale production for manufacturing, we offer optimized scale-up services. Our facilities and team are equipped to handle both high-throughput screening and large-scale production runs, ensuring quality and consistency across different stages of your project.
Project Consultation & Requirement Discussion
You can reach us via phone, email, or online forms to share your project background, objectives, and specific requirements for peptide-oligonucleotide conjugation, including molecular structures, modification types, and purity standards.
Solution Design & Quotation
Our technical team will promptly develop a detailed conjugation plan tailored to your needs, including molecular design, synthesis route, technical challenges, and quality control measures, along with an accurate quotation.
Contract Signing & Project Initiation
Upon mutual agreement on the solution and pricing, we will sign a formal service contract and initiate the project immediately. A dedicated project manager will oversee every stage to ensure smooth progress.
Synthesis & Purification
Following the established plan, we synthesize peptides and oligonucleotides under strictly controlled reaction conditions to ensure efficiency. After synthesis, advanced purification techniques are applied to remove impurities and unreacted materials.
Quality Testing & Delivery
Purified conjugates undergo rigorous quality testing, including mass spectrometry for molecular weight and structural confirmation, as well as HPLC analysis for purity assessment. Products are delivered only after meeting all quality criteria, accompanied by a detailed quality report for your reference.
As a classical method for peptide synthesis, we continuously optimize our solid-phase synthesis processes, improving efficiency and product purity. This method is particularly advantageous for synthesizing long-chain and complex peptides.
For specific structural requirements or large-scale synthesis, we employ liquid-phase synthesis, enabling flexible and efficient peptide-oligonucleotide conjugation.
By integrating advanced automated peptide synthesizers, we achieve precise control over the synthesis process, enhancing efficiency, reproducibility, and minimizing human error.
Our facility is equipped with a wide range of high-precision analytical instruments, including UPLC, HPLC, LCMS, UPLCMS, 2D-LCMS, LCMSMS, QE, GCMSMS, ICPMS, IR, UV, NMR, and XRPD. These instruments ensure comprehensive, accurate quality analysis and structural characterization of peptide-oligonucleotide conjugates.
Extensive Project ExperienceWith years of experience in peptide-oligonucleotide conjugation services, we have supported projects spanning from basic research to preclinical drug development. Our team has accumulated deep technical expertise and strong project management capabilities.
Expert Technical TeamLed by PhD-level scientists with extensive R&D experience, our team excels in peptide chemistry, nucleic acid chemistry, and drug design. We provide one-stop professional technical support, from molecular design to synthesis optimization.
State-of-the-Art Technology PlatformOur facility is equipped with world-class technology, including multi-channel automated peptide synthesizers and high-precision liquid chromatography-mass spectrometry (LC-MS) systems, ensuring robust hardware support for high-quality peptide-oligonucleotide conjugation services.
Fast Turnaround TimeThanks to our optimized synthesis processes and efficient production workflows, we are able to deliver projects quickly without compromising quality.
Stringent Quality Assurance
Peptide-oligonucleotide conjugates hold immense potential in oncology, antiviral therapies, and neurological disease treatment. For example, by utilizing peptides as targeting carriers, oligonucleotide drugs (such as siRNA and miRNA) can be precisely delivered to diseased cells, enhancing therapeutic efficacy.
Our conjugation technology enables the design and synthesis of highly specific and high-affinity bioprobes, applicable in biomarker detection, disease diagnostics, and drug screening.
Peptide-oligonucleotide conjugates serve as efficient gene delivery vectors, enhancing gene transfection and expression while improving the safety and effectiveness of gene therapy.
The synthesis timeline varies depending on molecular complexity, modification type, and production scale. We will discuss project timelines with you in advance and strive for on-time delivery.
We enforce strict quality control measures to ensure that our conjugate products meet your required purity standards.
We utilize advanced conjugation techniques and optimized reaction conditions to ensure high specificity and stability. Key reaction parameters, such as temperature, pH, and reaction time, are precisely controlled. Additionally, our comprehensive analytical methods verify conjugate quality, ensuring optimal performance in downstream applications.
