Selenization of Amino Acids
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Selenization of Amino Acids

BOC Sciences has a high -quality professional and technical team, many years of service experience and standardized laboratories. It can provide fast and efficient selenic amino acid selenization modification synthesis and selenium amino acid analysis services according to the actual needs of customers. Our service areas include not only selenization of amino acids, but also involved the fields of modification areas such as phosphorylation, methylation, hydroxylization, glycosylation, and acetylization of amino acids.


Amino acid is the basic unit of protein molecules in the organism, which is closely related to life activities. It is an important material basis for constituting the body and life. It has special physiological functions and is one of the indispensable nutritional elements in the organism. Selenium is a trace element necessary for biological body. It has a variety of immune and biological functions and can prevent cardiovascular disease, antitumor, antiviral, and anti -aging. Compared with inorganic selenium compounds, organic selenium compounds have the advantages of strong biological activity, low toxicity, high absorption rate, and less pollution. Organic selenium compounds include selenoamino acids, selenotea polyphenols, selenolinoleic acid, selenolinolenic acid, etc.

Why Choose Us?

Selenoamino acids mainly include selenomethionine and selenocysteine. Highly active selenoamino acids play an important role in food, medicine, health care, and feed. We can obtain selenoamino acids through biosynthesis and chemical synthesis. In addition, we can also use a variety of analytical methods for qualitative and quantitative analysis of selenoamino acids to detect the content and form of organic selenium.

Structures of common selenoamino acidsStructures of common selenoamino acids

Our Services

  • Selenization of Methionine

The main structural feature of methionine is that it contains sulfur. The sulfur element in methionine can be replaced by selenium under certain conditions to generate selenomethionine.

    • Chemical synthesis

We can use methionine as raw material to industrially produce selenomethionine through various chemical reactions.

    • Biosynthesis

Fermentation and enzymatic methods are mainly used.

  • Selenization of Cysteine

Selenocysteine is the major form of selenium in proteins. Methylated derivatives of selenocysteine have promising anticancer prospects.

    • Chemical synthesis

Reaction of chloroalanine and sodium diselenide to generate selenocysteine, and then reduction with metallic sodium/liquid ammonia to obtain selenocysteine. The obtained selenocysteine can be obtained through an alkylation reaction to obtain a methylated derivative of the selenocysteine.

    • Biosynthesis

We produce selenocysteine by microbial fermentation. Firstly, a strain with high selenium tolerance was bred, and on this basis, mutagenesis breeding was used for further screening. Fermentation optimization was carried out on the screened strains with high selenocysteine production. Finally, the strain is used for fermentation to realize the production of selenocysteine.

  • Detection of Selenoamino Acids
    • High-performance liquid chromatography (HPLC) method: suitable for the detection of APIs containing selenium amino acids
    • Reverse-phase high-performance liquid chromatography (RP-IP-HPLC)-inductively coupled plasma mass spectrometry (ICP-MS) method: suitable for speciation analysis of selenium-containing small molecules (such as selenocystine, selenomethionine, selenomethylcysteine, etc.) in various biological samples.
    • Liquid chromatography-tandem mass spectrometry (LC-MS-MS): simultaneous determination of two compounds in one injection, suitable for the content determination of selenomethionine and selenocysteine.
    • Liquid chromatography-atomic fluorescence spectrometry method: It can be used for routine analysis of selenium species in urine samples and pharmaceuticals.
    • Gas chromatography (GC) method: suitable for the determination of trace amounts of selenoamino acids (such as selenocystine, selenomethionine, and selenocysteine).
    • Gas chromatography-mass spectrometry (GC-MS) method: suitable for qualitative and quantitative analysis of selenomethylcysteine and selenomethionine in food.
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