BOC Sciences has a high -quality professional and technical team, many years of service experience and standardized laboratories. It can provide fast and efficient selenic amino acid selenization modification synthesis and selenium amino acid analysis services according to the actual needs of customers. Our service areas include not only selenization of amino acids, but also involved the fields of modification areas such as phosphorylation, methylation, hydroxylization, glycosylation, and acetylization of amino acids.
Amino acid is the basic unit of protein molecules in the organism, which is closely related to life activities. It is an important material basis for constituting the body and life. It has special physiological functions and is one of the indispensable nutritional elements in the organism. Selenium is a trace element necessary for biological body. It has a variety of immune and biological functions and can prevent cardiovascular disease, antitumor, antiviral, and anti -aging. Compared with inorganic selenium compounds, organic selenium compounds have the advantages of strong biological activity, low toxicity, high absorption rate, and less pollution. Organic selenium compounds include selenoamino acids, selenotea polyphenols, selenolinoleic acid, selenolinolenic acid, etc.
Selenoamino acids mainly include selenomethionine and selenocysteine. Highly active selenoamino acids play an important role in food, medicine, health care, and feed. We can obtain selenoamino acids through biosynthesis and chemical synthesis. In addition, we can also use a variety of analytical methods for qualitative and quantitative analysis of selenoamino acids to detect the content and form of organic selenium.
Structures of common selenoamino acids
The main structural feature of methionine is that it contains sulfur. The sulfur element in methionine can be replaced by selenium under certain conditions to generate selenomethionine.
We can use methionine as raw material to industrially produce selenomethionine through various chemical reactions.
Fermentation and enzymatic methods are mainly used.
Selenocysteine is the major form of selenium in proteins. Methylated derivatives of selenocysteine have promising anticancer prospects.
Reaction of chloroalanine and sodium diselenide to generate selenocysteine, and then reduction with metallic sodium/liquid ammonia to obtain selenocysteine. The obtained selenocysteine can be obtained through an alkylation reaction to obtain a methylated derivative of the selenocysteine.
We produce selenocysteine by microbial fermentation. Firstly, a strain with high selenium tolerance was bred, and on this basis, mutagenesis breeding was used for further screening. Fermentation optimization was carried out on the screened strains with high selenocysteine production. Finally, the strain is used for fermentation to realize the production of selenocysteine.