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Cbz-Thr-Phe-Thr(tBu)-OMe is a protected tripeptide used in peptide synthesis. The Cbz (Carbobenzyloxy) group protects the N-terminus of the first threonine (Thr) residue, preventing it from participating in unwanted reactions during the synthesis process. The side chain of the second threonine residue is protected by a tBu (tert-butyl) group, shielding the hydroxyl group from reactivity until selective deprotection is needed. Phe (Phenylalanine), the middle amino acid, contributes aromatic and hydrophobic properties to the peptide sequence. The OMe (methyl ester) at the C-terminus indicates that the carboxyl group of the second threonine is esterified, which is useful for controlling the reactivity and allowing further modifications or elongation of the peptide chain. This compound is employed to introduce threonine and phenylalanine into peptides, with specific protections to ensure selective and controlled synthesis.
